Subclinical myocardial injury in clinically healthy obese dogs
[ N/A ]
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Israel Veterinary Medical Association
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs. © 2020, Israel Veterinary Medical Association. All rights reserved.
Açıklama
Anahtar Kelimeler
Cardiac Biomarkers, Hypertension, Metabolic Disorder, Troponin
Kaynak
Israel Journal of Veterinary Medicine
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
75
Sayı
3
