Subclinical myocardial injury in clinically healthy obese dogs

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dc.authorscopusid57191851431
dc.authorscopusid57078919700
dc.authorscopusid57193393546
dc.authorscopusid57211960026
dc.authorscopusid57210173011
dc.authorscopusid57214148414
dc.authorscopusid6701698266
dc.contributor.authorNaseri, Amir
dc.contributor.authorIder, M.
dc.contributor.authorGulersoy, E.
dc.contributor.authorKoral, E.
dc.contributor.authorErturk, A.
dc.contributor.authorDurgut, M.K.
dc.contributor.authorOk, M.
dc.date.accessioned2024-09-19T15:45:25Z
dc.date.available2024-09-19T15:45:25Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the relationship between obesity and adipokines and also to determine subclinical myocardial injury by cardiac biomarkers. Twenty-five healthy obese (HO) and 15 healthy normal weight (HN) mixed breed dogs were enrolled in the study. Blood sampling and cardiologic examination were performed in all dogs in order to exclude any diseases. The HO group had higher levels of triglycerides (P<0.005), glucose (P<0.025), and lower levels of creatinine (P<0.010) compared to HN dogs. HO dogs had higher serum leptin (P<0.001) but lower adiponectin concentrations (P<0.009) than HN dogs. Systolic blood pressure (P<0.004) and serum concentration of cardiac troponin T was significantly higher in HO dogs compared to HN dogs (P<0.038). There was no statistical significance in concentrations of blood urea nitrogen, alanine aminotransferase, alkaline phosphatase, albumin, total protein, cholesterol, cardiac troponin I, and N-terminal pro brain natriuretic peptide between HO and HN dogs. The bivariate analysis revealed that triglyceride, leptin and systolic blood pressure had positive (r=0.45, P<0.01; r=0.78, P<0.001; r=0.46, P<0.05, respectively) and adiponectin had negative correlation with body condition score (r=-0.39, P<0.05). Cardiac troponin T had a positive correlation with systolic blood pressure (r=0.56, P<0.01). The findings indicate that unfavorable metabolic and lipid changes in obese dogs and systemic hypertension have harmful effects on the myocardium. Elevation of serum cardiac troponin T in obese dogs compared to healthy dogs could represent a probable subclinical myocardial damage in obese dogs. © 2020, Israel Veterinary Medical Association. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research Officeen_US
dc.identifier.endpage167en_US
dc.identifier.issn0334-9152
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85090798204en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14673
dc.identifier.volume75en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIsrael Veterinary Medical Associationen_US
dc.relation.ispartofIsrael Journal of Veterinary Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac Biomarkersen_US
dc.subjectHypertensionen_US
dc.subjectMetabolic Disorderen_US
dc.subjectTroponinen_US
dc.titleSubclinical myocardial injury in clinically healthy obese dogsen_US
dc.typeArticleen_US

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