Yazar "Onmaz, A. C." seçeneğine göre listele

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    Circulating mineral element concentrations in Sakiz crossbred lambs with pica disorder
    (Ecole Nationale Veterinaire Toulouse, 2010) Aytekin, I.; Onmaz, A. C.; Kalinbacak, A.; Aypak, S. U.; Alp, H.
    The aims of this study were to determine the serum calcium, phosphorus, magnesium, cupper, zinc and iron concentrations in lambs with pica disorder, and to evaluate the efficiency of mineral preparation as treatment. The study was performed on 25 Sakiz crossbred lambs, 1-2 months old, whose 15 lambs exhibiting clinical signs for pica (soil eating, surface licking, wool-eating, weight loss, development retardation and a strong desire to eat non-food objects) and 10 were apparently healthy. Blood samples were taken for measuring serum concentrations of minerals and trace elements 5 days before and after treatment with a vitamin-mineral combination (Kalmina (R) VIL-SAN, 0.3 ml/kg, IV). Whereas serum Ca, Mg, P, Cu and Zn concentrations did not significantly differ between affected and healthy lambs, it was observed a marked decrease of iron concentration (P < 0.05) in all animals with pica. After Kalmina (R) injection, clinical signs of pica totally disappeared in 67% of diseased lambs (10/15) and a significant increase of P concentrations compared to initial values (P < 0.05) was observed associated with slight and not significant increases of serum Cu and Zn concentrations. The sideremia was also significantly enhanced (P < 0.05) but remained below control values, particularly in the 5 lambs which still presented an abnormal behaviour. Consequently, it was concluded that iron deficiency may play an important role for the aetiology of pica and the mineral element supplementation could be beneficial for the treatment of lambs with pica.
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    Effects of 2,4-D (dichlorophenoxyacetic acid) on blood anti-oxidant oxidant balance and on tissues in lambs
    (Ecole Nationale Veterinaire Toulouse, 2010) Aytekin, I.; Onmaz, A. C.; Alp, H.; Ulucan, A.
    In this study, the effects of the common herbicide 2,4-D (dichlorophenoxyacetic acid) on blood antioxidant / oxidant status and on various organs were investigated in Sakiz crossbred lambs. For that, 6 lambs were poisoned accidentally with the herbicide whereas 6 other healthy animals served as negative controls and plasma MDA and GSH concentrations as well as serum ascorbate, retinol and beta-carotene concentrations were determined by spectrophotometry two days later. In parallel, conventional histological analysis was performed on lungs, liver, kidney and heart front a lamb dead after 2,4-D exposure. Blood antioxidant/oxidant balance was altered due to a significant increase of MDA concentrations coupled to a significant decrease of GSH concentrations in intoxicated lambs compared to controls. Congestive lesions and some haemorrhages were evidenced in lungs and kidneys and cell degeneration associated with lymphocyte infiltrate were observed in liver, kidneys and in heart. These results highly suggest that the herbicide 2.4-D induces an oxidative stress leading to cell destructions and tissue injury.
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    Effects of accidental ammonium Sulphate poisoning on antioxidant/oxidant status in lambs
    (Ecole Nationale Veterinaire Toulouse, 2011) Aytekin, I.; Onmaz, A. C.; Ulucan, A.; Alp, H.
    In this study, the effects of the ammonium sulphate intoxication on the blood antioxidant /oxidant status were investigated in Sakiz crossbred lambs. For that, circulating blood urea nitrogen (BUN), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), beta-carotene, retinol and ceruloplasmin concentrations were measured in 6 lambs accidentally poisoned with ammonium sulphate and in 6 healthy control lambs. Oral treatment with 10% glutamic acid (1g/kg), 2.5% acetic acid (2.5 mL/kg) and vitamin A (400 IU/kg) was daily administered to diseased animals for five days. Poisoned lambs exhibited neurological signs (sleepiness, ataxia, tonic and clonic spasms) coupled to a rumen atony and acceleration of heart and respiratory rates compared to healthy controls. Biochemically, the circulating MDA, NO and BUN concentrations were markedly increased and the GSH, beta-carotene and vitamin A concentrations were significantly depressed compared to healthy controls whereas the ceruloplasmin concentrations were not significantly altered. After treatment, clinical and biochemical signs were significantly alleviated but, however 2 lambs died. For them, the histopathological examinations after haematoxylin-eosin staining revealed cell degeneration in liver, lungs and kidney associated to mononuclear cell infiltrates and proliferation of Kiipffer cells. These results clearly showed the occurrence of an oxidative stress induced by ammonium sulphate poisoning leading to cell damage and proved the efficiency of a treatment based on organic acids and retinol supplementation.