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    8-hydroxy-2?-deoxyguanosine, malondialdehyde and protein carbonil levels as indicators of oxidative stress in patients with sickle cell anemia
    (Wiley-Blackwell, 2014) Ecevit, H.; Ozcan, O.; Izmirli, M.; Can, Y.; Gurpinar, A. B.; Ozturk, O.
    [Abstract Not Available]
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    Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury
    (Elsevier Science Bv, 2014) Dokuyucu, Recep; Karateke, A.; Gokce, H.; Kurt, R. K.; Ozcan, O.; Ozturk, S.; Tas, Z. A.
    Objective: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Study design: Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion + erdosteine 100 mg/kg, detorsion + alpha lipoic acid (ALA) 100 mg/kg, and detorsion + erdosteine + ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. Results: The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (p < 0.05). Strong correlation was found between OSI and total histological score in the sham, torsion and detorsion groups (r = 0.765, p < 0.001). The mean levels of TOS and OSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (p < 0.05). Mean TOS and mean OSI were lower in the detorsion + erdosteine + ALA group compared with the detorsion + erdosteine and detorsion + ALA groups (p < 0.05). In comparison with the detorsion group, the numbers of primordial follicles (p = 0.006) and primary follicles (p = 0.036) were increased in the groups that received erdosteine and/or ALA. Conclusions: Erdosteine and ALA decreased ischaemia-reperfusion injury in an experimental rat ovarian torsion model; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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    Öğe
    Erratum: Impact of Enoxaparin +a Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model (European Review for Medical and Pharmacological Sciences (2022) 26:18 (6583-6592) DOI: 10.26355/eurrev_202209_29758)
    (Verduci Editore s.r.l, 2022) Ozcil, M. Dogan; Ozcan, O.; Hakverdi, S.; Bayraktar, H.S.; Dirican, E.; Kacmaz, F.
    After publication, the authors applied a correction to the Funding statement: “This Project was supported by the Scientific Research Projects Coordination Unit at Hatay Mustafa Kemal University. Project Number: 18. M. 088.” There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. The correct section is reproduced below. © 2022 Seismological Society of America. All rights reserved.
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    Impact of Enoxaparin +? Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model
    (Verduci Editore s.r.l, 2022) Ozcil, M. Dogan; Ozcan, O.; Hakverdi, S.; Bayraktar, H.S.; Dirican, E.; Kacmaz, F.
    OBJECTIVE: With this study we aimed at investigating the impact of enoxaparin (E) and ?-lipoic acid (?-LA) on ischemia/reperfusion (I/R) damage in an experimental ovarian torsion (T) detorsion (D) model. MATERIALS AND METHODS: The study comprised 80 female albino rats aged 12 weeks. They were divided into 8 groups as follows, with 10 rats in each group: Group 1 (Sham), Group 2 (Ischemia, 3 hours), Group 3 (I/R, 6 hours reperfusion), Group 4 (I/R, 3 days reperfusion), Group 5 (I/R, E, 6 hours), Group 6 (I/R, E, 3 days), Group 7 (I/R, E+?-LA, 6 hours), and Group 8 (I/R, E+?-LA, 3 days). Immediately after detorsion, enoxaparin (0.5 mg/kg/day, sc) or ?-LA (100 mg/kg/day, ip) were administered. Ovarian levels of malondialdehyde (MDA), glutathione peroxidase (GPx), and catalase were measured. In addition to total Antioxidant Status (TAS) and Total Oxidative Stress (TOS), the Oxidative Stress Index (OSI) was calculated. Serum levels of AMH, FSH, LH, E2, and progesterone were measured. Ovarian samples were histopathologically examined and they underwent Tag staining for apoptosis. RESULTS: Compared with the sham group, there was a significant increase in TOS, OSI, and MDA levels in I/R group (p<0.001). Compared to Group 2, a significant increase was determined in TOS and OSI in Group 3 (p<0.05). In Group 4, a significant increase was found compared to Group 2 (p<0.01). The lowest level of I/R damage and the highest level of antioxidants were found in Group 2, 7, and 8. The highest values of TOS, OSI, and MDA were found in Group 3, Group 4, Group 5, and Group 6 (p<0.001). When the sham group and Group 4 were compared, it was found that AMH and E2 levels decreased (p<0.001), while FSH levels increased (p<0.001). In Group 6, AMH and E2 values were significantly decreased compared to the sham group (p<0.001). In the histopathological examination, the findings were observed to be parallel to those of the biochemical markers. CONCLUSIONS: Combined use of ?-Lipoic acid and enoxaparin prevents oxidative stress and ovarian damage due to ischemia-reperfusion injury better than the use of drugs alone. © 2022 Verduci Editore s.r.l. All rights reserved.
  • [ N/A ]
    Öğe
    Impact of Enoxaparin +? Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model (vol 26, pg 6583, 2022)
    (Verduci Publisher, 2022) Ozcil, M. Dogan; Ozcan, O.; Hakverdi, S.; Bayraktar, H. S.; Dirican, E.; Kacmaz, F.
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    Impact of Enoxaparin plus a Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model
    (Verduci Publisher, 2022) Ozcil, M. Dogan; Ozcan, O.; Hakverdi, S.; Bayraktar, H. S.; Dirican, E.; Kacmaz, F.
    OBJECTIVE: With this study we aimed at investigating the impact of enoxaparin (E) and alpha-lipoic acid (alpha-LA) on ischemia/reper-fusion (I/R) damage in an experimental ovarian torsion (T) detorsion (D) model. MATERIALS AND METHODS: The study com-prised 80 female albino rats aged 12 weeks. They were divided into 8 groups as follows, with 10 rats in each group: Group 1 (Sham), Group 2 (Ischemia, 3 hours), Group 3 (I/R, 6 hours reper-fusion), Group 4 (I/R, 3 days reperfusion), Group 5 (I/R, E, 6 hours), Group 6 (I/R, E, 3 days), Group 7 (I/R, E+alpha-LA, 6 hours), and Group 8 (I/R, E+alpha-LA, 3 days). Immediately after detorsion, enoxaparin (0.5 mg/kg/day, sc) or alpha-LA (100 mg/kg/day, ip) were administered. Ovarian levels of malondial-dehyde (MDA), glutathione peroxidase (GPx), and catalase were measured. In addition to total An-tioxidant Status (TAS) and Total Oxidative Stress (TOS), the Oxidative Stress Index (OSI) was calcu-lated. Serum levels of AMH, FSH, LH, E2, and pro-gesterone were measured. Ovarian samples were histopathologically examined and they underwent Tag staining for apoptosis.RESULTS: Compared with the sham group, there was a significant increase in TOS, OSI, and MDA levels in I/R group (p<0.001). Compared to Group 2, a significant increase was determined in TOS and OSI in Group 3 (p<0.05). In Group 4, a significant increase was found compared to Group 2 (p<0.01). The lowest level of I/R dam-age and the highest level of antioxidants were found in Group 2, 7, and 8. The highest values of TOS, OSI, and MDA were found in Group 3, Group 4, Group 5, and Group 6 (p<0.001). When the sham group and Group 4 were compared, it was found that AMH and E2 levels decreased (p<0.001), while FSH levels increased (p<0.001). In Group 6, AMH and E2 values were signifi-cantly decreased compared to the sham group (p<0.001). In the histopathological examination, the findings were observed to be parallel to those of the biochemical markers.CONCLUSIONS: Combined use of alpha-Lipoic ac-id and enoxaparin prevents oxidative stress and ovarian damage due to ischemia-reperfusion in-jury better than the use of drugs alone.