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    Assessment of Ischemia Modified Albumin as a Marker of Oxidative Stress in Chronic Kidney Disease
    (Wolters Kluwer Medknow Publications, 2021) Ozkurt, Sultan; Ozcan, Oguzhan; Dogan, Ibrahim
    Increased oxidative stress (OS) in chronic kidney disease (CKD), and particularly in those undergoing hemodialysis (HD), is widely recognized. We aimed to evaluate ischemia modified albumin (IMA) as a marker of OS in CKD patients who are not yet on HD compared to chronic HD patients. A cross-sectional study was conducted in Hitit University, Corum, Turkey in 2015. In this study, 39 chronic HD and 36 CKD patients in stage 3-4 were included, as well as 34 healthy individuals as a control group. IMA levels in HD patients (before and after HD session), stage 3-4 CKD patients and control group were evaluated using the ELISA method. Pre-HD and post-HD albumin levels were measured and albumin-adjusted IMA (aIMA) levels were calculated. IMA and aIMA levels were higher in chronic HD and CKD patients who are not yet on HD, compared to healthy individuals (IMA, 179.76 +/- 60.46, 209.67 +/-& nbsp; 69.84, 67.41 +/- 32.22, P < 0.001, respectively, aIMA, 186.22 +/-& nbsp; 64.84, 212.96 +/-& nbsp; 72.84, 68.80 +/- ; 34.42, P < 0.001, respectively). Likewise, IMA and aIMA levels in post-HD patients were higher than pre-HD levels (IMA, 294.62 +/- 66.64, 179.76 +/-& nbsp; 60.46, P < 0.001, respectively, aIMA, 298.31 +/-& nbsp; 70.93, 186.22 & PLUSMN; 64.83, P < 0.001). Linear regression analysis identified glomerular filtration rate as the most effective factor on IMA (P < 0.001). CKD is associated with increased OS and the HD procedure itself also contributes to the increase in OS. IMA may serve as a feasible biomarker for determination of OS.& nbsp;
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    Comparison of shoulder Magnetic Resonance Imaging findings between patients with stage 4 chronic kidney disease and hemodialysis patients with healthy controls
    (Ios Press, 2020) Turk, Ayla Cagliyan; Fidan, Nurdan; Ozcan, Oguzhan; Ozkurt, Sultan; Musmul, Ahmet; Sahin, Fusun
    BACKGROUND: Shoulder involvement is frequently observed in chronic renal disease (CRD) and hemodialysis patients. OBJECTIVE: Our aim is to compare shoulder Magnetic Resonance Imaging (MRI) findings of stage 4 CRD patients naive to dialysis, hemodialysis patients and healthy controls. METHODS: Twenty hemodialysis patients with shoulder pain (Group 1), 30 hemodialysis patients without shoulder pain (Group 2), 20 patients with stage 4 CRD (Group 3) and 30 healthy controls (Group 4) were enrolled. Urea, creatinine and beta 2 microglobulin were measured. Thickness, homogeneity and integrity of rotator cuff and presence of effusion were examined by MRI. RESULTS: Supraspinatus tendon was thicker in Group 1 compared to other groups, whereas infraspinatus tendon was thicker in Group 1 compared to Groups 2 and 4. Although all tendons thickness was higher in Group 3 than Group 4, there was no significant difference. Most effusion areas were present in Group 1, followed by Groups 2 and 3. There was a significant correlation between glomerular filtration rate and thickness of supraspinatus, infraspinatus tendons and between beta 2 microglobulin and thickness of infraspinatus, subscapularis tendons and total number of areas with effusion. CONCLUSIONS: Increased shoulder tendon thickness and effusion were detected in symptomatic dialysis patients, while greater effusion areas were detected in asymptomatic dialysis patients and in stage 4 CRD patients who do not require dialysis compared to healthy controls.
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    Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease
    (Springer, 2019) Ozkurt, Sultan; Dogan, Ibrahim; Ozcan, Oguzhan; Fidan, Nurdan; Bozaci, Ilter; Yilmaz, Behice; Bilgin, Muzaffer
    PurposeThe decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. The profibrotic mediator of galectin-3 (Gal-3) is linked to development of renal fibrosis.MethodsThe study included 74 patients with ADPKD diagnosis and 40 healthy controls. The TKV of patients was calculated using the manual tracing method on MR images. The serum Gal-3 levels of patient and healthy control groups were measured with the ELISA method. The correlations between serum Gal-3 value with TKV and kidney function were assessed in patients.ResultsAs the stage of chronic kidney disease (CKD) increased, serum Gal-3 and TKV values increased (p<0.001, p=0.049, respectively). Correlation analysis found a negative relationship between serum Gal-3 levels and eGFR (r: -0.515, p<0.001); however, there was no relationship between serum Gal-3 and TKV (r=0.112, p=0.344). Linear regression analysis showed the major parameter affecting Gal-3 was eGFR (p=0.016).ConclusionsIn our study, we showed that renal impairment is an important determinant of Gal-3, and there is no correlation of Gal-3 and TKV in ADPKD. As a result, there is an urgent clinical need for new biomarkers to identify individuals with the chance of treatment in the early stage among ADPKD patients.
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    IS OXIDATIVE STRESS ASSOCIATED WITH TOTAL KIDNEY VOLUME IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE?
    (Oxford Univ Press, 2020) Dogan, Ibrahim; Eser, Bads; Aydemir, Nihal; Kayadibi, Huseyin; Ozcan, Oguzhan; Fidan, Nurdan; Ozkurt, Sultan
    [Abstract Not Available]
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    Painful and painless shoulder Magnetic Resonance Imaging comparisons in hemodialysis patients and correlation with clinical findings
    (Ios Press, 2017) Turk, Ayla Cagliyan; Fidan, Nurdan; Ozcan, Oguzhan; Ozdemir, Ferda; Tomak, Leman; Ozkurt, Sultan; Sahin, Fusun
    BACKGROUND: Shoulder pain is frequently observed in haemodialysis patients. OBJECTIVE: To compare haemodialysis patients with or without shoulder pain in terms of shoulder motion ranges, beta 2 microglobulin levels and magnetic resonance imaging findings. METHODS: Forty-three patients undergoing dialysis were enrolled, of which 23 patients had explicit shoulder pain at night, which appeared during dialysis. Range of joint motion was evaluated. beta 2 microglobulin value was recorded. MRI was used to evaluate rotator cuff tendons for thickness, homogeneity, integrity and presence of effusion. RESULTS: Ranges of motion were significantly lower in the painful shoulder group. Supraspinatus tendon thickness and the number of areas with effusion were higher in the painful group. There was a positive correlation between the beta 2 microglobulin level and supraspinatus (r:0.352 p < 0.05) and subscapular (r:0.454 p < 0.05) tendon thicknesses. While effusion areas and pain (r:0.351 p < 0.05) showed positive correlation, there was a negative correlation between pain and shoulder motion ranges. CONCLUSIONS: Shoulder pain in dialysis patients can be related with tendon thickness and effusion. While the beta 2 microglobulin level affects tendon thickness, it has no relation to pain and movement constraint.