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Öğe Age-related changes in cat brains as demonstrated by histological and immunohistochemical techniques(Ecole Nationale Veterinaire Toulouse, 2010) Ozsoy, S. Y.; Haziroglu, R.The aim of the study was to investigate the brain pathological changes according to ageing in cats. For that, brains of 24 cats (over 10 years old) were compared with those of 8 younger cats (1-2 years old) using haematoxylin and eosin (HE), Periodic acid-Schiff (PAS) and von Kossa stains and immunohistochemical labelling for neuron-specific enolase (NSE), 2,3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), ubiquitin, glial fibrillary acidic protein (GFAP) and beta-amyloid protein (A beta). Cerebral and cerebellum atrophy with ventricular dilatation were observed for all aged cat brains. Histologically, these changes were frequently associated with fibrosis of meningeal vessels and hyalinosis of the choroid plexus, with neuronal degeneration (characterized by intense vacuolisation and swelling, white matter spongiosis, ubiquitin and NSE labelling and lipofuscinosis coupled to mineralization areas in the oldest cats) and also with severe gliosis (proliferation of Bergmann's glial cells and numerous positive GFAP and CNPase cells). Furthermore A beta deposits were mainly observed in vessel walls (in 91.7% of old cats) and as senile plaque (in 83.3% of cases). These age-related alterations of brain observed in cats were similar to those observed in humans and in other old mammals.Öğe Evaluation of blood omega-3 and omega-6 levels in healthy female dogs and female dogs with mammary tumours(Hellenic Veterinary Medical Soc, 2021) Tuzlu, T.; Saribay, M. K.; Urer, E. Koldas; Kose, A. M.; Gozer, A.; Yakan, A.; Ozsoy, S. Y.The study was designed to determine the blood levels of omega fatty acids, which have an important role in the etiology of mammary tumours, in healthy and female dogs with mammary tumour. The study was carried out in 9 female dogs with histologically confirmed mammary tumour and a control group with 9 healthy female dogs without clinical mammary neoplasia. 10 ml cephalic blood samples were collected by using a 21G x 1.5.. blood collecting needle into anticoagulated tubes before the surgical removing of the mammary masses. Mastectomy was performed in all female dogs with mammary tumours and all the mammary specimens were sent to laboratory for histopathological examination. According to histopathological diagnosis results, all of the tumours were found to be malignant. Omega-3 levels were found to be higher in healthy female dogs (p<0.001) whereas omega-6 levels were higher in female dogs with mammary tumour (p<0.001). These observations support the notion tha thigh levels of omega-3 fatty acids might proove to have a protective role on mammary tumor formation in female dogs, while increased levels of omega-6 fatty acids may be related to an increased mammary tumor risk. This difference between omega-3 and omega-6 levels was found to be caused mainly by Eicosatrienoic acid. It is concluded that omega fatty acids mayplay an important role in the biological mechanism of mammary tumour in female dogs.Öğe Evaluation of the age related changes in dog brains(Ecole Nationale Veterinaire Toulouse, 2010) Haziroglu, R.; Guvenc, T.; Tunca, R.; Ozsoy, S. Y.; Ozyildiz, Z.In this study it was aimed to compare the pathological findings on the brains of aged and young dogs. The research material consisted the brains of 20 dogs over 10 years old and brains of 10 dogs with an age of 1-2 years old. The brains were first of all examined macroscopically afterwards the tissue samples were taken from telencephalon, mesencephalon, rhombencephalon for histopathological and immunohistochemical investigations. In the aged dogs brains macroscopic examinations revealed meningeal thickness and ventricular dilatation. Microscopically, fibrosis at choroid plexus, meninges and vascular walls also ependymal defects, gliosis and neuronal depletion were observed in the aged dogs brains. On semi quantitative examination of the sections, a statistically significant increase on Glial Fibrillary Acidic Protein (GFAP) and 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expressions were determined in old dogs compared to young dogs (P<0.01).Öğe Evaluation of the eye diseases seen in Loggerhead Sea turtle (Caretta caretta)(Ecole Nationale Veterinaire Toulouse, 2014) Isler, C. T.; Altug, M.; Cantekin, Z.; Ozsoy, S. Y.; Yurtal, Z.; Deveci, M. Z. Y.Fifteen Loggerhead turtles (Caretta caretta) admitted to the First Aid, Treatment and Rescue Application and Research Centre between 2011 and 2012 underwent systematic ophthalmological examination. They have got injury of traumaticum in its cranium. Of these animals, six presented various ocular problems in a total of nine eyes: two catarrhal conjunctivitis, two purulent conjunctivitis, three keratitis, two blepharitis and two corneal lacerations. From macroscopic examination, these ocular problems were seen to have been associated with clinical signs such as chemosis, exophthalmos, blepharospasm, mucopurulent discharge, conjunctival hyperemia and diffuse corneal opacity. Histopathological examination also detected an infiltration of macrophages, plasma cells and lymphocytes, mainly mononuclear cells in corneal stroma. Aeromonas spp. was isolated in eye swabs of the purulent conjunctivitis cases. All cases successfully recovered following topical and parenteral antibiotic treatments combined with systemic vitamin A and balanced fluid-electrolyte administrations.Öğe Investigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats(Taylor & Francis Ltd, 2020) Altinok-Yipel, F.; Tekeli, I. O.; Ozsoy, S. Y.; Guvenc, M.; Sayin, S.; Yipel, M.The aim of this study was to investigate hepatoprotective effect of some algae species such as Spirulina platensis, Chlorella vulgaris, Laminaria japonica, Sargassum sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl4) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl4 at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl4 (p < .05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl4 (p < .05). Based on these results, algae species able to minimise the toxic effects of CCl4 and especially S. platensis could be used in the purpose of protection against chemical-induced hepatotoxicity.Öğe Pathological findings in intracranial tumours in dogs: 13 cases(Ecole Nationale Veterinaire Toulouse, 2009) Ozsoy, S. Y.; Vural, S. AtalayIn the study, macroscopic and microscopic diagnosis was obtained in intracranial tumours from 13 dogs. These dogs (8 males and 5 females) were between 4-14 years old and did not belong to brachycephalic breeds except for 2 dogs. The primary brain tumours identified were meningiomas (n = 5), choroid plexus papilloma (n = 3) and glial tumours (3 astrocytomas and 1 oligodendroglioma and a same dog exhibited simultaneously 2 distinct types of brain tumours, i.e. papilloma and oligodendroglioma. In addition, 2 secondary tumours (squamous cell carcinoma and anasplastic carcinoma) were also diagnosed and resulted from direct expansion of sinus tumours.Öğe The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats(Taylor & Francis Ltd, 2014) Ozmen, E.; Ozsoy, S. Y.; Donmez, N.; Ozsoy, B.; Yumusak, N.We investigated the protective effects of L-carnitine on hippocampus tissue damage in rats during experimental formaldehyde (FA) intoxication. Male Wistar albino rats were assigned into four groups: (1) control (C), (2) formaldehyde (FA), (3) formaldehyde + 0.5 g/kg of L-carnitine (FA + 0.5 LC) (4) formaldehyde + 1 g/kg L-carnitine (FA + 1 LC). At the end of the 14 day trial period, animals were sacrificed by decapitation under anesthesia. The hippocampus tissue samples were extracted to measure MDA, GSH and SOD activity. Neuronal degeneration was assessed based on histopathological (hematoxylin and eosin) and immunohistochemical (anti-ubiquitin) examination. To detect oxidative stress, specimens were reacted with anti-Cu/Zn-SOD antibody. After administering L-carnitine with FA to the animals, the activities of SOD and GSH increased, but the levels of MDA decreased in hippocampus tissue. Neuronal degeneration was observed in the FA group. L-carnitine administration reduced neuronal degeneration and histological structure was similar to controls. After FA application, degenerated hippocampus neurons were stained with anti-ubiquitin and Cu/Zn-SOD antibodies; weakly positive staining was observed in L-carnitine-treated groups. L-carnitine may be useful for preventing oxidative damage in the hippocampus tissue due to formaldehyde intoxication.Öğe Protective effect of L-carnitine on experimental lead toxicity in rats: a clinical, histopathological and immunohistochemical study(Taylor & Francis Ltd, 2011) Ozsoy, S. Y.; Ozsoy, B.; Ozyildiz, Z.; Aytekin, I.Female Wistar-albino rats were given lead acetate (PbAc) for 60 days to investigate the protective effects of L-carnitine (CA) clinically and histopathologically on PbAc-induced tissue damage. Blood samples were obtained from the jugular vein for hemoglobin (HB), hematocrit (HCT), red blood cells (RBC), white blood cells (WBC), platelets (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine. PbAc treatment caused a significant decrease in HB, HCT and RBC, a significant increase in WBC, AST, ALT and creatinine compared to controls. Although administration of CA did not reverse HB and HCT values, it reversed both the decrease in RBC and the increase in WBC, AST, ALT and creatinine. After the experimental period, all rats were weighed, then decapitated for pathological examination. Control rat liver, kidney and brain showed normal histological architecture. Lead-induced nephropathic kidneys; degenerative changes, inflammation and portal edema of the liver; and brain neuropil vacuolation, neuronal vacuolation, satellitosis and neuronophagia were observed in experimental groups. All changes were reduced in the PbAc group treated with CA (PbAc + CA). PbAc caused copper/zinc superoxide dismutase (Cu/Zn-SOD) expression in both the hepatocytes and tubular epithelium of the kidney. PbAc + CA exposure caused moderate Cu/Zn-SOD immunoreactivity. While in the brain sections of the PbAc group the degenerative neurons were stained intensely with anti-ubiquitin antibody, PbAc + CA rats showed moderate staining in neurons with anti-ubiquitin antibody. These results show that CA as a food additive reduced the severity of tissue damage caused by PbAc.
