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Öğe Comparison of azithromycin and a combination of trypsin, chymotrypsin and papain proteolytic enzymes for the treatment of bovine cutaneous papillomatosis(Univ Nacional Autonoma Mexico Facultad Medicina Veterinaria Zootecnia, 2022) Deveci, Mehmet Zeki Yilmaz; Altus, Muhammed Enes; Alaku, Halil; Ozsoy, Sule YurdagulAlthough various methods have been used in the treatment of bovine cutaneous papillomatosis (BCP), no definite treatment has yet been established. There are no studies regarding the efficacy of azithromycin (AZ) and of any combination of trypsin, chymotrypsin, and papain proteolytic enzymes (PEC) in the treatment of BCP. The objective of this study was to investigate the efficacy of AZ and PEC in the treatment of BCP. A total of 24 female Holstein cattle of 6-17 months of age with spontaneous BCP were used for this study. In addition to the clinical findings, the diagnosis was confirmed with histopathological examinations. The animals were divided at random into three groups (n = 8). The AZ group received 10 mg/kg/day PO for 10 days. In the PEC group, an injectable suspension of proteolytic enzymes was applied IM at 0.4 mL/10 kg dose, 3 times with 8-10 days interval and the spray was used topically once a day for 10 days. The control group (CO) was not treated. The mean in papilloma warts decreased 92.4 % in the AZ group, 83.38 % in the PEC group, and 59.48 % in the CO. There were statistically significant differences in warts presence decreases between the three groups (P < 0.05). Both AZ and PEC were considered successful for the BCP treatment. However, AZ was found more effective than PEC.Öğe Corneal papilloma associated with papillomavirus in a one-humped camel (Camelus dromedarius)(Wiley, 2010) Kilic, Nuh; Toplu, Nihat; Aydogan, Ahmet; Yaygingul, Rahime; Ozsoy, Sule YurdagulA 15-year-old male dromedary camel with a history of chronic severe keratoconjunctivitis and corneal mass in the left eye of 6 months' duration was referred to the Veterinary Medical Teaching Hospital at Adnan Menderes University. A superficial keratectomy was performed and biopsy material submitted for histopathology. The diagnosis was corneal papilloma. There has been no recurrence of the neoplasm to date (6 months, 1 year). Corneal papilloma has not been reported previously in camels and seems to be associated with papillomavirus.Öğe Detection of bovine respiratory syncytial virus, Pasteurella multocida, and Mannheimia haemolytica by immunohistochemical method in naturally-infected cattle(Walter De Gruyter Gmbh, 2018) Yaman, Turan; Buyubayram, Huseyin; Ozyildiz, Zafer; Terzi, Funda; Uyar, Ahmet; Keles, Omer Faruk; Ozsoy, Sule YurdagulIntroduction: The aim of this study was to determine the predisposing effect of bovine respiratory syncytial virus (BRSV) on Pasteurella spp. infection in naturally-induced pneumonia in cattle by immunohistochemical labelling. Material and Methods: Lungs of cattle slaughtered in the slaughterhouse were examined macroscopically, and 100 pneumonic samples were taken. The samples were fixed in 10% neutral formalin and embedded in paraffin by routine methods. Sections 5 mu m in thickness were cut. The streptavidin-peroxidase method (ABC) was used to stain the sections for immuno-histochemical examination. Results: BRSV antigens were found in the cytoplasm of epithelial cells of bronchi, bronchioles, and alveoles and within inflammatory cell debris and inflammatory exudate in bronchial lumens. Pasteurella spp. antigens were detected in the cytoplasm of the epithelial cells of bronchi and bronchioles, and in cells in the lumens of bronchi and bronchioles. Eleven cases were positive for only one pathogen (six for BRSV and five for Pasteurella spp.), while 35 cases were positive for 2 pathogens: BRSV plus P. multocida (n = 21) or M. haemolytica (n = 14). Conclusion: The presence of high levels of BRSV in dual infections indicates that BSRV may be the main pneumonia-inducing agent and an important predisposing factor for the formation of Pasteurella spp. infections in cattle naturally afflicted with pneumonia.Öğe Effect of essential oil supplementation to diet on meat quality, fatty acid composition, performance parameters and intestinal microbiota of Japanese quails(Wiley, 2021) Kurekci, Cemil; Ozsoy, Bulent; Hassan, Errol; Ozkan, Huseyin; Gundogdu, Aycan; Ozsoy, Sule Yurdagul; Yakan, AkinThe effect of essential oil (EO) supplementation on carcass characteristics of Japanese quails and interactions between ingredients and intestinal morphology were investigated in this study. A total of 250 quails were fed different diet: D1, basal diet (BD); D2, BD plus palmarosa oil (PO; 100 mu g/kg diet); D3, BD plus lemon myrtle oil (LMO; 100 mu g/kg diet); D4, BD plus alpha-Tops (mixture of alpha-terpineol, cineole and terpinene-4-ol; 100 mu g/kg diet); and D5, BD plus cyclodextrin. Overall growth performance was determined at multiple time points during 35 days of experiment. Carcass characteristics (fatty acid, pH and colour), intestinal morphology and the expression levels of meat quality-related genes including the insulin-like growth factor (IGF-1), myogenin and avian uncoupling protein (avUCP) were examined at the end of the trial. Additionally, intestinal microbiome of quails was studied by next-generation sequencing-based culture-independent analysis. Although the inclusion of EOs into the diet had no effect on the growth performance of quails and the microbial profile, the significant changes in pH(24)and colour (a*) of the quail's breast muscle (p < .05) in the group receiving PO were observed. Additionally, oleic acid content in the breast muscle was significantly higher in the EOs supplemented groups (p < .01). Quails fed the PO supplemented diet had higher villus and relatively rich in oleic acid. The expression levels of IGF-1 and myogenin genes in quail's muscle were not affected, but the expression of avUCP gene was significantly lower in quails fed with LMO and alpha-Tops (p < .05). The results demonstrated variable effects of these treatments on intestinal morphology. Taken together, dietary inclusion of EOs is found to be beneficial and hence can be recommended for improving the quality of poultry meat.Öğe Effects of a Single Application of Adcon Gel on Peritendinous Adhesion: An Experimental Study in Rabbits(Journal Hard Tissue Biology, 2014) Ozden, Raif; Uruc, Vedat; Duman, Ibrahim Gokhan; Dogramaci, Yunus; Kalacı, Aydıner; Komurcu, Erkam; Ozsoy, Sule YurdagulPeritendinous adhesions are serious complications after surgical repair of tendons and can lead to poor functional outcome. In the present study, the tensile strength of repaired tendons was measured biomechanically in two groups using a rabbit Achilles tendon model, and the effects of Adcon gel on peritendinous adhesions and tendon healing were examined by means of histological and mechanical analyses. In the treatment group, the Achilles tendon was transected, followed by a primary repair using a modified Kessler technique, and Adcon gel was injected between the tendon and skin of the right leg. The same operation was done for the control group, and 1 mL of normal saline solution was applied locally in a similar fashion. The experimental protocols were approved by the local animal ethics committee. Microscopic evidence of the formation of adhesions and of inflammation was less in the treatment group than in the control group. There was no significant difference in the tensile load necessary to rupture the repaired tendons between the two groups. Adcon gel reduced the peritendinous adhesions histologically without impairing tendon healing, as determined with mechanical analyses. The use of Adcon gel may provide a simple means of preventing of postoperative peritendinous adhesions, thereby offering a beneficial effect on tendon repair.Öğe Effects of incubator oxygen and carbon dioxide concentrations on hatchability of fertile eggs, some blood parameters, and histopathological changes of broilers with different parental stock ages in high altitude(Elsevier, 2022) Okur, Nezih; Eratalar, Sabri Arda; Yigit, Ayse Arzu; Kutlu, Tuncer; Kabakci, Ruhi; Ozsoy, Sule YurdagulThe effects of incubator carbon dioxide (CO2) and oxygen (O-2) concentrations with parental stock age (PSA) on embryonic deaths (ED), hatchability of fertile eggs (HFE), some blood parameters, and the tissue development of broilers were investigated. Four consecutive repetitions following the similar materials and methods were carried. From 3 different aged ROSS 308 broiler parental flocks 7,680 hatching eggs were obtained and classified as young (Y; 29 wk), middle (M; 37 wk) and old (O; 55 wk) as regards PSA, and randomly distributed. Four different incubator ventilation programs (IVP) as control (C; 0.67% CO2 and 20.33% O-2), high CO2 (HC; 1.57% CO2 and 20.26% O-2), high O-2 (HO; 0.50% CO2 and 21.16% O-2), and high CO2 + O-2 (HCO; 1.17% CO2 21.03% O-2) were applied with oxygen concentrator, and ED and HFE were investigated. Lung and heart tissues, hemoglobin value, packed cell volume, and red blood cell count, triiodothyronine, thyroxine, adrenocorticotropic hormone (ACTH) values of the chicks were analyzed. It was found that IVP affected ED and HFE. Higher rate of early ED (EED) was obtained from the HC than HCO, and higher middle+late stage +pipped but unhatched ED (MLPED) with a lower rate of HFE was observed in the C group than HO and HCO (P < 0.05). Association was found between PSA and IVP (P < 0.05), being more evident in EED for young PSA, in MLPED with HFE for Y and O PSA. From hematological values, no statistical difference in RBC, PCV, and Hb values were found among the treatment groups, ACTH concentration known as a response to stress was found to be higher than C in all groups, triiodothyronine concentration was higher in the HO group than C. In the histopathological examination, used IVPs were found to have negative effects on the lung and heart such as vacuolization, hemorrhage in all PSA groups except for C. Conclusively, PSA and IVP affected some hatching, blood and tissue development parameters of the broiler chicks.Öğe Formaldehyde technique in dimensional stability of free fascia: An animal study(Taylor & Francis As, 2010) Aslan, Sundus; Savas, Nazan; Ozsoy, Sule Yurdagul; Dagli, SafakConclusion. Despite the fact that this was a study done with fascia other than the temporalis, we found that non-formaldehyde-formed and formaldehyde-formed fascia graft shrunk by a mean value of 26.5%, and 16.7%, respectively, which was statistically significant. This finding might be the explanation for the consistently reported successful outcomes in tympanoplasty carried out with formaldehyde-formed temporalis fascia. However, this study should be validated with autologous human temporalis fascia graft. Objectives. To determine whether there is any difference in the dimensional stability of free fascia grafts when formed with formaldehyde or not. Materials and methods. In a total of 22 rats, free fascias were prepared with 4% buffered formaldehyde solution in 11 and without formaldehyde in the other 11 rats. All fascia grafts of 1 x 1 cm were implanted under the insicion site of the same rat (autograft). All rats were re-operated after 5 days to measure the dimensions of the grafts. The postoperative changes in the dimensions were calculated. Results. By the 5th day, the mean non-formaldehyde-formed graft surface area was 73.51 +/- 13.43 mm(2) and the mean formaldehyde-formed graft surface area was 83.28 +/- 10.50 mm(2) respectively. After 5 days there was a mean decrease in surface area of the non- formaldehyde-formed and formaldehyde-formed grafts of 26.49 +/- 13.43 mm and 16.72 +/- 10.50 mm(2), respectively. It was found that formaldehyde-formed fascia exhibited significantly superior dimensional stability when compared with non-fixed fascia during the 5 days of the early healing phase (p=0.031).Öğe Hepatoprotective Activity of Linalool in Rats Against Liver Injury Induced by Carbon Tetrachloride(Verlag Hans Huber, 2020) Altinok-Yipel, Fulya; Tekeli, Ibrahim Ozan; Ozsoy, Sule Yurdagul; Guvenc, Mehmet; Kaya, Alpaslan; Yipel, MustafaThis study aimed to investigate and compare hepatoprotective activity of Coriandrum sativum (Cs) and it is major component linalool (Ln) against experimentally induced hepatotoxicity in rats. Essential oil of Cs was isolated by hydrodistillation method and chemical composition was determined by GS-MS analysis. 42 male Wistar Albino rats were divited into 7 groups each containing 6. The experimental groups were designed as: Normal control group, 1 ml/kg CCl4 administirated group, 25 mg/kg Silymarin and CCl4 administirated group, 100 and 200 mg/kg Cs and CCl4 administirated groups, 100 and 200 mg/kg Ln and CCl4 administered groups. The protective activities were determined according to the results of liver biomarkers (AST, ALT, ALP), antioxidant parameters (GSH, GPx, CAT), lipid peroxidation (MDA) and histopathological examination. Linalool percentage of Cs was 81.6%. The groups treated with linalool (100 and 200 mg/kg) (p < 0.01) and coriander (200 mg/kg) (p < 0.05) had significantly reduced AST (262-375) and ALT (101-290) levels (U/L) compared to the CCl4 (600-622) group. The levels (nmol/g protein) of MDA (11-12) were significantly lower (p < 0.01), the levels of GSH (11-12) and the activities of CAT (23-24) were significantly higher (p < 0.01) in linalool groups (100 and 200 mg/kg) compared to the CCl4 (18-5-10 respectively) group. These results were also supported by histopathological findings and indicate that Cs and Ln shows hepatoprotective activity against liver damage. In this regard, evaluation of activities of major components are needed to compare to medicinal plants in experimental diseases models.Öğe Investigation of the anti-apoptotic activity of ozone therapy in rainbow trout macrophages infected with Yersinia ruckeri(Springer, 2019) Kucukgul, Azime; Kucukgul, Altug; Gonenci, Ramazan; Ozsoy, Sule Yurdagul; Kutlu, Banu; Isgor, Mehmet MustafaYersinia ruckeri is the causal agent of enteric redmouth (ERM) in trout. This study aimed to investigate the effectiveness of nontoxic ozone on Y. ruckeri-infected trout cells in in vitro conditions. Rainbow trout macrophages (RTS-11) were exposed to Y. ruckeri for 24h after being incubated with the ozonized medium at nontoxic concentration. Effective concentrations of nontoxic ozone (3 gamma) and bacteria (1.5x10(8)cfu/mL) were determined by viability tests. The expression of caspases 1, 3, 8, and 12 was determined by real-time PCR and protein levels investigated by ELISA method. Apoptotic-necrotic cell ratios were determined by acridine orange and ethidium bromide staining. Bacterial stimulations of caspases (1, 3, 8, and 12) were suppressed by ozone mostly at the translational level. While bacterial infection increased the count of apoptotic and necrotic cells at different stages, ozone significantly reduced this condition. Obtained data indicate possible use of nontoxic ozone as a safe and effective treatment alternative for increasing host defenses and eliminating the infection in the case of yersiniosis in fish.Öğe Molecular, biochemical, and histopathological effects of long-term low and high-percentage fructose consumption on the liver in rats(Ankara Univ Press, 2022) Ozkan, Huseyin; Kutlu, Tuncer; Yakin, Akin; Ozsoy, Sule YurdagulThe aim of this study was to investigate the lipogenic and inflammatory effects of low and high percentage fructose solutions in rats. Wistar albino rats were fed with fructose solutions for 10 weeks. The groups were as follows: Cont (Control), F15 (Fructose 15%), F30 (Fructose 30%), and F60 (Fructose 60%). Rats' body weights were measured weekly. Also, lipogenic and inflammatory gene expression levels, biochemical parameters, and histopathological changes in the liver were investigated. After 10 weeks, it was observed that the animals in the F60 were the heaviest, while the animals in the F30 were the lightest. In all experimental groups, triglycerides were significantly higher than those of controls (P<0.05). In F30 and F60, TNF alpha, IL-6, and IL-1/1 were upregulated in the liver compared to control (P<0.05). In addition, SREBP-1c, ChREBP, FAS, ACACA, and SCD-1 were upregulated in all fructose feeding groups compared to Cont (P<0.05). The livers of rats in the F30 and F60 groups had degenerative changes and steatosis. The most detrimental effects of fructose were observed in F60. The concentration of fructose was found to be a very important factor for maintaining normal liver physiology at the molecular level.Öğe Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats(Wiley, 2020) Guvenc, Mehmet; Cellat, Mustafa; Gokcek, Ishak; Ozkan, Huseyin; Arkali, Gozde; Yakan, Akin; Ozsoy, Sule YurdagulThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of experiment; the Nobiletin group (group 3), nobiletin (10 mg/kg) for 10 days; and the APAP + Nobiletin group (group 4), nobiletin (10 mg/kg) for 10 days with a single dose of APAP (1000 mg/kg) administered on the 10th day and the experiment ended after 48 hours. At the end of the study, a significant increase in malondialdehyde, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels and a significant decrease in glutathione levels, glutathione peroxidase activities and nuclear factor erythroid-derived 2-like 2 (Nrf-2) and heme oxygenase-1 (HO-1) expressions were observed with APAP application in liver and kidney tissues. Serum aspartate transaminase (AST), alanine transaminase (ALT), urea, and creatinine levels were also significantly increased in the APAP group. However, nobiletin treatment in group 4 reversed oxidative stress and inflammatory and histopathological signs caused by APAP. It is concluded that nobiletin may be a beneficial substance that confers hepatorenal protection to APAP-induced toxicity via antioxidant and anti-inflammatory mechanisms.Öğe Pathological and Microbiological Investigations of Pneumonic Pasteurellosis in Sheep(Kafkas Univ, Veteriner Fakultesi Dergisi, 2013) Ozyildiz, Zafer; Tel, Osman Yasar; Yilmaz, Rahsan; Ozsoy, Sule Yurdagul; Keskin, OktayIn this study, between March 2010 and March 2011, 110 pneumonia suspected lung tissues were examined histopathologically, immunohistochemically and microbiologically, in Sanliurfa province. After definition of the macroscopic localization of the consolidated areas in the lungs, tissue samples were taken and preserved in cold chain and 10% formalin for microbiological and pathological examinations, respectively. For bacteriological examination of Pasteurella spp. lung specimens were inoculated in 7% sheep blood agar and Mc Conkey agar. After routine pathological tissue follow up procedure, tissues were embedded in paraffin and obtained sections stained with Hematoxylin&Eosin (H&E). The cases, having histopathological findings consistent with pneumonia, were forwarded to immunohistochemical (IHC) examinations to know whether lesions related to Mannheimia haemolytica and Pasteurella multocida using hyperimmune polyclonal rabbit sera in Avidin Biotin Complex Peroxidase (ABC-P). Microbiological, histopathological and immunohistochemical findings were comparatively evaluated in examined animals. Pasteurella multocida as a cause of pneumonia were detected in 38 cases of microbiological inoculations. Immunohistochemical staining resulted Mannheimia haemolytica (n=35) and Pasteurella multocida (n=30) positive. Immunohistochemically both Mannheimia haemolytica and Pasteurella multocida were positive in 23 cases and 45 animals were negative for both bacteria. The aim of this study is to show importance and role of Pasteurella spp, in sheep pneumonia in Sanliurfa region.Öğe Pleural mesothelioma in a nine-month-old dog(Veterinary Ireland, 2007) Vural, Sevil Atalay; Ozyildiz, Zafer; Ozsoy, Sule YurdagulThis paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3mm to 6cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonal-shaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.Öğe Preventive and Curative Effects of Medical Ozone in Rats Exposed to Experimental Osteomyelitis(Univ Agriculture, Fac Veterinary Science, 2017) Gonenci, Ramazan; Tabur, Mehmet; Ozsoy, Sule YurdagulInvestigation of preventive and therapeutic effects of medical ozone in rats with acute osteomyelitis was aimed in this study. Staphylococcus aureus solution was injected intramedullary into right femurs of each animal to form acute osteomyelitis. Preventive Osteomyelitis Group (POG) was taken an ozone session by rectal insufflation daily at a dose of 500 mu g/kg for 15 days with an ozone generator starting a week before microorganism injections, whereas applied nothing to Untreated Osteomyelitis Group (UOG). Treatment Osteomyelitis Group (TOG) was administered the same ozone therapy sessions as POG. But this application was started just after 4 days following the microorganism injection. At the end of the ozone-therapy, two femurs of each animal in 3 groups were excised and examined radiographically, microbiologically and histopathologically. It was found that radiographical differences between UOG and other two osteomyelitis groups were significant, but those between POG and TOG were insignificant. There was not any microbiological reproduction in conventional culture methods. Histopathologically; mild, moderate and severe inflammation findings in the POG, TOG and UOG were observed respectively. Histopathological healing was significant in TOG compared to UOG, and it was significant in POG compared to TOG. Conclusively, it was thought that preventive and curative effects of medical ozone in rats exposed to experimental osteomyelitis had been found. (C) 2017 PVJ. All rights reservedÖğe Pulmonary aspergillosis in a foal(Ankara Univ Press, 2009) Ozsoy, Sule Yurdagul; Haziroglu, RifkiIn the study, macroscopic, microscopic and immunohistochemical findings of pulmonary aspergillosis was described, in a 23 day old, English breed, female foal. At necropsy 0.2-0.5 cm diameter, difficulty in appearance, greyish in colour nodules with severe hyperemia was observed at lung. Microscopically fungi hyphas with septums were determinated in some alveoli and bronchial lumens by hematoxylin-eosin, Periodic acide Schiff and immunoperoxidase staining methods.
