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Öğe Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model(Wolters Kluwer Medknow Publications, 2019) Yildiz, Hasan; Kalipci, Erkan; Oztas, Haydar; Yildiz, DenizAim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal -SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.Öğe Inhibitory effects of Aspirin on Azaserine initiated pancreatic carcinogenesis in rat(Indian Veterinary Journal, 2008) Yildiz, Hasan; Koc, Ahmet; Oztas, Haydar; Yildiz, DenizIn vitro experiments and limited animal studies suggest that aspirin, nonsteroidal anti-inflammatory, drug may inhibit pancreatic carcinogenesis. So far researchers have evaluated the biochemical and metabolic properties of aspirin but there has not been any experimental study performed on the anticarcinogenesis effect of aspirin on the well-known azaserine-rat model for pancreatic carcinogenesis. This study was designed to evaluate the potential anticarcinogenetic effect of aspirin.Öğe Investigation of Possible Ecotoxic Effects of Acrylamide on Liver with the Azaserine-Rat Model(Hard, 2012) Kalipci, Erkan; Yener, Yesim; Yildiz, Hasan; Oztas, HaydarIn this study, when acrylamide is taken into the body by nutrition, it was aimed to investigate its ecotoxic and/or carcinogenic effects on the liver. The Azaserine-Rat model developed by Longnecker and Curphey was used in this research, and in total 60 Wistar Albino race male rats were used, including 10 rats in each group. The rats were fed for 16 weeks by adding acrylamide at rates of 5 mg/kg/day and 10 mg/kg/day in drinking water. Moreover, neoplastic structures were formed by azaserine application and its effect on the development of these neoplastic structures was also investigated. As a result of this study, it was determined that ecotoxic and histopathological alterations, together with atypical cells, focuses formed in the livers of the rats in the group to which azaserine was applied and in the livers of the rats in the groups that included 5 and 10 mg/kg/day acrylamide in their drinking water. Moreover, it was found that the development (average focus diameter and focus volume) of neoplastic structures formed with azaserine was increased by 5 and 10 mg/kg/day acrylamide. These results make it possible for the probability of acrylamide to be a cancer initiator in the livers of rats.Öğe Methyl parathion-induced changes in free and protein-bound SH levels in rat tissues(Taylor & Francis Ltd, 2006) Yildiz, Deniz; Dalkilic, Semih; Yildiz, Hasan; Oztas, HaydarThe main objective of this study was to investigate the changes in free and protein-bound SH contents in methyl parathion-exposed rat tissues. The free and protein-bound SH levels are usually affected and depleted by oxidative stress-inducing agents. Results would indicate if methyl parathion toxicity partly results from depletion of sulfhydryl content of tissues. Six-week-old male Wistar albino rats were used in this study. Following exposure to methyl parathion for 3 months, the liver, the brain, and the kidney tissues were removed from the rats. The free and protein-bound SH contents were determined in these tissues. In addition, plasma lactate dehydrogenase levels were determined. Our results showed that methyl parathion exposure significantly lowers the free and protein-bound SH levels in rat tissues. However, lactate dehydrogenase activity in the blood plasma did not display any differences compared to the control group. The free SH concentrations in the control rat liver, brain, and kidney tissues were 3.78 +/- 0.1 mu mol/100 mg tissue, 1.56 +/- 0.08 mu mol/100 mg tissue, and 2.16 +/- 0.08 mu mol/100 mg tissue, respectively, whereas the free SH concentrations in rats exposed to methyl parathion were determined as 0.536 +/- 0.1 mu mol/100 mg tissue in the liver, 1.06 +/- 0.1 mu mol/100 mg tissue in the brain, and 0.108 +/- 0.03 mu mol/100 mg tissue in the kidney. The protein-bound SH concentrations in the liver and in the kidney in rats exposed to methyl parathion displayed a significant decrease also. However, the protein-bound SH level in the brain did not change significantly. These results indicate that methyl parathion exposure partially depletes the free and protein-bound SH levels. Thus, it was concluded that methyl parathion toxicity may partly result from oxidative stress.Öğe Potential neoplastic effects of parathion-methyl on rat liver(Science Press, 2009) Coral, M. Nisa Unaldi; Ucman, Sonay; Yildiz, Hasan; Oztas, Haydar; Dalkilic, SemihThe mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.
