Yazar "Ozturk, Sevket" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    ANTIPROLIFERATIVE EFFECTS OF Origanum syriacum L. AND Myrtus communis L. ON HUMAN COLON CANCER CELL LINE
    (Incdtp-Icpi, 2018) Ozturk, Sevket; Duran, Nizami
    In this study, we aimed to investigate the composition and antiproliferative efficacy of Origanum syriacum L. and Myrtus communis L. essential oils on the HCT cell line. Also, it was aimed to search the synergistic activities of Origanum syriacum L. and Myrtus communis essential oils with MTX (Methotrexate) on HCT 116 cells. The main essential oil components of Origanum syriacum L. were Thymol (42,18%), Carvacrol (33,95%), Cymene (8,87%), gamma-Terpinene (8,21%) and for Myrtus communis L. the main essential oil components were Eucalyptol (45,41%), alpha-Pinene (20,86%), Linalool (9,71%). In this study, HCT 116 human colon cancer cell line and Vero cell line were used. To determine the non-cytotoxic concentration of Origanum syriacum L. and Myrtus communis L. essential oils Vero cell line was selected. The cytotoxic activity of the essential oils was measured using the MTT method and the results were evaluated as IC50. The Inhibition concentrations of the essential oils of Origanum syriacum L. and Myrtus communis L. essential oils against cancer HCT 116 and Vero cells were evaluated. It has been found that the essential oils of the Origanum syriacum L. and Myrtus communis have an important antiproliferative effect on human colon cancer cells. In our study findings, we think that these two plant essential oils may be a potent drug active compound for cancer treatment.
  • Küçük Resim
    Öğe
    The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
    (Korean Institute Chemical Engineers, 2016) Ghica, Mihaela Violeta; Albu, Madalina Georgiana; Kaya, Durmus Alpaslan; Popa, Lacramioara; Ozturk, Sevket; Rusu, Laura-Cristina; Dinu-Pirvu, Cristina
    The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
  • Küçük Resim
    Öğe
    Selection of Optimal Operating Conditions for Extraction of Myrtus Communis L. Essential Oil by the Steam Distillation Method
    (Mdpi, 2020) Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Danila, Elena; Ozturk, Sevket; Turkmen, Musa; Albu Kaya, Madalina Georgiana; Dinu-Pirvu, Cristina-Elena
    Myrtus communis L. is one of the important aromatic and medicinal species from the Mediterranean area. It is used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, and industrial applications. Thus, a Box-Wilson experimental plan was used in this study to select the optimal operating conditions in order to obtain high volumes of essential oils. The factorial design method was applied to evaluate at an industrial scale the effect of major process variables on the essential oil extraction from Myrtus communis L. herbs by the steam distillation method. The input variables considered as significant operating conditions were: X-1-boiler occupancy rate (boilers were filled to 50%, 75%, and 100%), X-2-distillation duration (distillation was continued 60, 75, and 90 min), and X-3-particle size (herbs were cut in sizes of 10, 20, and 30 mm via guillotine). The dependent variable selected, coded as Y, was the essential oil volume obtained (mL). The steps of the classical statistical experimental design technique were complemented with the Taguchi method to improve the extraction efficacy of essential oil from Myrtus communis L., and the optimum parameter conditions were selected: boiler occupancy rate 100%, distillation duration 75 min, and particle size 20 mm. Following the optimum parameters, the GC-MS assay revealed for the Myrtus communis L. essential oil two predominant components, alpha -pinene-33.14% and eucalyptol-55.09%.