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    Delayed diagnosis of traumatic diaphragmatic hernia may cause colonic perforation: A case report
    (2009) Ozkan, Orhan Veli; Semerci, Ersan; Yetim, Ibrahim; Davran, Ramazan; Diner, Guvenc; Paltaci, Ilhan
    Early diagnosis of diaphragmatic rupture after traumas may be difficult, and delayed diagnosis may result in increased morbidity and mortality. This paper describes the case of a 32-year-old man who experienced a traffic accident and had diagnosis of traumatic diaphragmatic hernia nearly four months later. The patient was referred to our emergency room suffering from ileus symptoms. Physical examination demonstrated an apparent abdominal distention, tenderness at the upper abdominal quadrants, rebound, and defense. Thoraco-abdominal X-rays and computerized tomography imaging demonstrated intestinal segments with air-fluid levels in thorax. Laparotomy was performed after a preoperative diagnosis of a strangulated-diaphragmatic hernia. At abdominal exploration, it was found that transverse colon and omentum entered into thorax through diaphragmatic defect located at the left diaphragm. Herniating colon segment was complicated with ischemic necrosis and perforation. In conclusion, colon necrosis and perforation may develop when early diagnosis of diaphragmatic ruptures are missed. © 2009 Ozkan et al.; licensee Cases Network Ltd.
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    Diffuse idiopathic varices in the colon characterized by lower gastrointestinal bleeding
    (Aves, 2014) Akkucuk, Seckin; Aydogan, Akin; Paltaci, Ilhan; Temiz, Muhiyittin
    Colon varices are very rare lesions that usually present as secondary to portal hypertension. Idiopathic colon varices are even rarer, and should be considered especially in the etiology of massive lower gastrointestinal bleeding. Forty-five year old male presented to our hospital with complaints of recurrent rectal bleeding for one week and severe anemia. The patient was transfused with 4 units of blood. His colonoscopy revealed diffuse submucosal varices. The tests performed for investigation of etiology did not reveal any portal pathology. The patient did not experience another episode of active bleeding during follow-up and was discharged with conservative recommendations. Idiopathic colon varices are rare but should be considered in the differential diagnosis of patients presenting with massive rectal bleeding. Conservative approach is first line of treatment, reserving segmental or total colectomy only for ongoing hemorrhage.
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    Protective effects of tirofiban hydrochloride, a glycoprotein IIb/IIIa inhibitor, on liver ischemia/reperfusion injury in rats
    (Acta Medica Mediterranea, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, Zafer
    Aims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein IIb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60- minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.
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    PROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATS
    (Carbone Editore, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, Zafer
    Aims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein Ilb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60-minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.
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    Squamous Cell Carcinoma Arising in Etiology of Chronic Pilonidal Sinus Disease: A Case Report
    (Derman Medical Publ, 2011) Yetim, Ibrahim; Semerci, Ersan; Ozkan, Orhan Veli; Paltaci, Ilhan; Diner, Guvenc
    Pilonidal sinus disease is usually placed in sakrokoksigeal area. The etiology is unknown exactly. The pathogenesis is assumed to deciduous hair penetration into the subcutaneous tissues and a foreign body-type reaction may then lead to formation of an abscess. Cellulitis, abscesses, fistulas are common complications in pilonidal sinus disease. Chronic inflammation may be factors in the development of some malignancies. Malignant degeneration is very rare complication in chronic pilonidal disease. We reported in this case, a squamous cell carcinoma in caused by untreated chronic pilonidal sinus.