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    Does severity of psoriasis increase coronary artery calcification?
    (Wiley-Blackwell, 2013) Sen, B. Bulbul; Rifaioglu, E. N.; Ekiz, O.; Buyukkaya, E.; Sen, N.
    [Abstract Not Available]
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    Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis
    (Wiley-Blackwell, 2013) Sen, B. Bulbul; Atci, N.; Rifaioglu, E. N.; Ekiz, O.; Kartal, I.; Buyukkaya, E.; Kurt, M.
    BackgroundCarotid intima-media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor. ObjectiveTo evaluate the association between EFT and CIMT in patients with psoriasis. MethodsThis was a cross-sectional and observational study; 65 patients with psoriasis and 50 age- and sex- matched control subjects were included. Data about echocardiographic EFT, CIMT, anthropometric measurements and metabolic profile were obtained. ResultsThe EFT and CIMT were significantly increased (7305 vs. 6505mm, P<001; 074011 vs. 060007mm, P<001, respectively) in patients with psoriasis compared with the controls. EFT was significantly correlated with CIMT (r=069, P<001). In a multiple linear regression model in which EFT was independently associated with psoriasis (=045, P<001), age (=033, P=001), CIMT (=050, P<001), body mass index (=025, P=001), high-sensitivity C-reactive protein (=032, P<001) and duration of disease (=034, P=003). ConclusionsWe demonstrated that EFT and CIMT are increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis.
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    Irritable bowel syndrome in patients with chronic pruritus of undetermined origin
    (Wiley, 2014) Ekiz, O.; Balta, I.; Ozuguz, P.; Sen, B. B.; Rifaioglu, E. N.; Ekiz, F.; Yuksel, I.
    Background Chronic pruritus is an important distressing condition that is often refractory to treatment. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that occurs without an organic cause. Objectives We aimed to investigate the relationship between chronic pruritus of undetermined origin (CPUO) and IBS. Methods Eighty patients with chronic pruritus (CP) of undetermined origin and fifty healthy control subjects without pruritus were included into the study. All of the participants were examined by a gastroenterologist for concomitant IBS. Results The frequency of IBS was found higher in patients with CP of undetermined origin (P: 0.02), but we did not observe any significant association between pruritus intensity and either presence of IBS (P: 0.08) or the subtypes of the syndrome (P: 0.40). Furthermore, patients with CP of undetermined origin between 40 and 60 years, female gender and longer duration of the disease were found to be significantly associated with the presence of IBS (P: 0.02, P: 0.01 and P < 0.001). Conclusions We found that the frequency of IBS was higher in patients with CP than in healthy controls. Our study is the first report about the relation between CP of undetermined origin and IBS. Further studies with larger numbers of the patients are needed to show association between IBS and CPUO using laboratory tests to define underlying diseases such as lactose intolerance, functional dyspepsia and emotional diseases.
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    Trichoscopy in Paediatric Patients with Tinea Capitis: A Useful Method to Differentiate from Alopecia Areata
    (Wiley, 2014) Ekiz, O.; Sen, B. B.; Rifaioglu, E. N.; Balta, I.
    Objectives Trichoscopy (hair and scalp dermatoscopy) facilitates the diagnosis of hair and scalp disorders. The aim of our study was to identify the trichoscopic features in diagnosis of tinea capitis (TC) and to compare these findings with alopecia areata (AA). Materials and Methods Our study included 15 children with TC and 10 children with AA as a control group. Affected areas of the scalp on all the cases were analysed under a magnification of 20X and 40X by a digital dermatoscope (Mole-Max II). Results Broken and dystrophic hairs were found in dermatological examination of all the patients with TC. In addition, corkscrew hairs, comma hairs and black dots were observed respectively. Yellow dots, exclamation mark hairs and vellus hair were observed in patients with AA. Conclusions Broken and dystrophic hairs, corkscrew hairs, comma hairs and black dots were observed only in patients with TC; yellow dots, exclamation mark hairs and vellus hairs were observed only in patients with alopesi areata. Further studies with larger numbers of patients are needed to determine specific trichoscopic findings of TC and to access differential diagnosis.