Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BackgroundCarotid intima-media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor. ObjectiveTo evaluate the association between EFT and CIMT in patients with psoriasis. MethodsThis was a cross-sectional and observational study; 65 patients with psoriasis and 50 age- and sex- matched control subjects were included. Data about echocardiographic EFT, CIMT, anthropometric measurements and metabolic profile were obtained. ResultsThe EFT and CIMT were significantly increased (7305 vs. 6505mm, P<001; 074011 vs. 060007mm, P<001, respectively) in patients with psoriasis compared with the controls. EFT was significantly correlated with CIMT (r=069, P<001). In a multiple linear regression model in which EFT was independently associated with psoriasis (=045, P<001), age (=033, P=001), CIMT (=050, P<001), body mass index (=025, P=001), high-sensitivity C-reactive protein (=032, P<001) and duration of disease (=034, P=003). ConclusionsWe demonstrated that EFT and CIMT are increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis.
Açıklama
Anahtar Kelimeler
Intima-Media Thickness, Coronary-Artery-Disease, Adipose-Tissue, Metabolic Syndrome, Risk-Factors, Cardiovascular-Disease, Diabetes-Mellitus, Inflammation, Association, Heart
Kaynak
British Journal of Dermatology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
169
Sayı
5
