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    Chemotaxonomy and flavonoid profiling of Torilis species by HPLC/ESI/MS2
    (Pergamon-Elsevier Science Ltd, 2011) Guzel, Yelda; Aktoklu, Ekrem; Roumy, Vincent; Alkhatib, Racha; Hennebelle, Thierry; Bailleul, Francois; Sahpaz, Sevser
    The flavonoid profiles of Turkish Torilis Gaertn. (Apiaceae) species were studied by TLC. HPLC-UV and HPLC/ESI/MS2 (negative mode). O-glycosides of luteolin, apigenin and chrysoeriol were identified from crude extracts with the help of mass spectra in different MS/MS modes, such as full scan, precursor ion scan and product ion scan. Luteolin-7-O-glucoside and luteolin-7-O-rutinoside were common to all species. Flavonoid profiles usually differ from one species to another and can be put to use for a genus such as Torilis which has been little studied. By the help of different flavonoid profiles, it is concluded that, the plants, which are recognised as less rayed subspecies of Torilis arvensis (Huds.) Link. in various floras including Turkish one, must be classified in species category as Torilis chrysocarpa and Torilis purpurea. Flavonoid profiles seem to be in relation with evolutionary biogeography of the species. Because the most isolated species of the genus, endemic Torilis triradiata, has the most different flavonoid pattern. Moreover, geographically isolated species, T triradiata and Torilis leptocarpa, do not share any flavonoid except for the two which are common to all species. (C) 2011 Elsevier Ltd. All rights reserved.
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    Humulane and Germacrane Sesquiterpenes from Ferula lycia
    (Amer Chemical Soc, 2010) Alkhatib, Racha; Hennebelle, Thierry; Joha, Sami; Roumy, Vincent; Guzel, Yelda; Biabiany, Murielle; Idziorek, Thierry
    Five new juniferol esters (1-5), along with six known humulane derivatives (6-11), were isolated from the roots of Ferula lycia, an endemic Turkish species. The fruits of the same species were also investigated and led to the isolation of these same compounds, as well as two known germacrane esters (12 and 13). All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2(BCR-ABL). The two most active compounds, juniferinin (7) and 6-beta-p-hydroxybenzoyloxygermacra-1(10),4-diene (12), were moderately active against Raji lymphoma cells but also displayed some toxicity against healthy bone marrow cells.