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    The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
    (Korean Institute Chemical Engineers, 2016) Ghica, Mihaela Violeta; Albu, Madalina Georgiana; Kaya, Durmus Alpaslan; Popa, Lacramioara; Ozturk, Sevket; Rusu, Laura-Cristina; Dinu-Pirvu, Cristina
    The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
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    Effects of harvesting hour on essential oil content and composition of Thymus vulgaris
    (2013) Kaya, Durmus Alpaslan; Arslan, Mehmet; Rusu, Laura-Cristina
    Diurnal variations in both fresh and dry leaf essential oils of Thymus vulgaris were evaluated in this study. Thymus vulgaris was harvested hourly starting at 6:00 and ending at 17:00. Fresh and dry leaf essential oil were extracted by hydrodistillation for 3 hours and analyzed by GC-MS. The results indicated that essential oil content significantly changed according to the hour of the day. The maximum oil yield was obtained by harvesting at the early hours of the day, which was found superior to oil yield corresponding to the late hours of the day. Thymol, ? -terpinen, p-cymene and carvacrol were the dominant essential oil components of both fresh and dry leaves of T. vulgaris. Except thymol, slight variations in essential oil composition of fresh and dry leaf of T. vulgaris were detected among harvesting hours. The results showed that the best harvesting hours of T. vulgaris for higher thymol concentrations were between 6:00 and 11:00.
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    EFFECTS OF HARVESTING HOUR ON ESSENTIAL OIL CONTENT AND COMPOSITION OF THYMUS VULGARIS
    (Soc Stiinte Farmaceutice Romania, 2013) Kaya, Durmus Alpaslan; Arslan, Mehmet; Rusu, Laura-Cristina
    Diurnal variations in both fresh and dry leaf essential oils of Thymus vulgaris were evaluated in this study. Thymus vulgaris was harvested hourly starting at 6:00 and ending at 17:00. Fresh and dry leaf essential oil were extracted by hydrodistillation for 3 hours and analyzed by GC-MS. The results indicated that essential oil content significantly changed according to the hour of the day. The maximum oil yield was obtained by harvesting at the early hours of the day, which was found superior to oil yield corresponding to the late hours of the day. Thymol, gamma-terpinen, p-cymene and carvacrol were the dominant essential oil components of both fresh and dry leaves of T. vulgaris. Except thymol, slight variations in essential oil composition of fresh and dry leaf of T. vulgaris were detected among harvesting hours. The results showed that the best harvesting hours of T. vulgaris for higher thymol concentrations were between 6:00 and 11:00.