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Öğe Amotivational syndrome: less known and diagnosed as a clinical(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ari, Mustafa; Sahpolat, Musa; Kokacya, M. Hanifi; Copoglu, U. SertanAmotivational syndrome (AS) is a disorder that includes apathy, callousness and antisocial behavior in chronic cannabis users. Some of these effects may generally be seen in other central nervous system depressants as well. Therefore, to make these effects specific for this syndrome is still debated. AS is usually seen among men during puberty. In different studies, the incidence of AS in regular cannabis users has been reported as between 16 to 21%. Although the causes accused in pathophysiology is still controversial, cannabis is the most commonly accused factor in the etiology. In neurobiology of the disease, noradrenergic and dopaminergic systems containing changes in limbic road have been blamed. The diagnosis is based on subjective complaints, and scored by clinical signs and Apathy Evaluation Scale (AES). There are very few experimental data available in treatment of AS, and clinical experience is very limited. By PubMed searching the keywords of 'amotivational syndrome, cannabis and amotivational syndrome, cannabis and motivation' from 1960 to December 2013, the published studies examining the relationship between marijuana and AS have been reviewed. We have reached 536 articles, of which 76 include direct relationship with AS, by the end of this search. Non-English articles were excluded from the study.Öğe A Case of Cannabis Use-Associated Psychotic Disorder Accompanied by Autoscopic Phenomena(Turkish Green Crescent Soc, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Sahpolat, Musa; Ari, MustafaCannabis (Marijuana) is one of the most commonly used illegal addictive substances. The psychiatric symptoms associated with cannabis use are agitation, insomnia, depressive or raised mood, anxiety, hallucinations, and concentration problems. It is known that cannabis use increases the risk for psychoses and bipolar disorders and may deteriorate the clinical presentation of pre-existing psychoses and bipolar disorders. A characteristic symptom of autoscopic psychosis is visual hallucination of some part or the entirety of a person's body, imitating his or her behaviors and being perceived as if seen in a mirror. This is not a specific symptom of any mental disorder and the cause is not definitively known. In this case presentation, the symptoms of a patient diagnosed with cannabis use-associated autoscopic psychosis are discussed in the context of the literature.Öğe Corpus Callosum Agenesis Presented with Attention Deficit Hyperactivity Disorder: Two Case Reports(Cukurova Univ, Fac Medicine, 2013) Sahpolat, Musa; Celik, Gonca; Avci, Ayse; Tahiroglu, AysegulADHD is a treatable neuropsychiatric disorder which can continue till adulthood. There have been three subtypes including attention deficiency, hyperactivity and impulsivity. Its etiology remains unclear yet. It is hypothesized that there is an impairment of neurodevelopment in early developmental periods through the interactions between genetic and environmental processes. Corpus callosum provides an integration of cognitive, sensorial and motor functions of brain as a response to the impulses originating from the cortex. The damage of this region may result in deterioration of some cerebral functions such as cognitive functions, speaking, learning ability and impulse control. In this paper, we report two pediatric cases who had comorbid attention deficiency and corpus callosum agenesis without mental retardation.Öğe The effect of the work environment on job satisfaction among nurses'(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Tambag, Hatice; Can, Rana; Kahraman, Yelda; Sahpolat, MusaObjective: The aim of this study to investigate comparison influencing the factors job satisfaction in nurses', determine reduce the satisfaction factors and recommendations to increase satisfaction. Material and Methods: This descriptive study was conducted in the Mustafa Kemal University Faculty of Medicine and Research Hospital in working who agreed to participate with 174 nurses. Data were collected by personal information questionnaire, Minnesota Job Satisfaction Scale (MJSS) and Work Environment Scale (WES). Results: Nurses' MJSS mean score is determined as 64.24 +/- 11.00 and WES total mean score is 88.52 +/- 11.66. WES total score (t=0.979; p=0.020), worker fears (t=0.196; p=0.042) and quality management (t=0.451; p=0.042) sub-scale scores of females were higher than males and significant. Conclusion: In this study participating nurses', job satisfaction is medium level and they evaluate positive their work environment; being female gender, being satisfied with the working department, higher socioeconomic status and having experienced any problems with other health professionals were determined as positive factors influencing job satisfaction.Öğe Elevated Monocyte to High-density Lipoprotein Ratios as an Inflammation Markers for Schizophrenia Patients(Korean Coll Neuropsychopharmacology, 2021) Sahpolat, Musa; Ayar, Duygu; Ari, Mustafa; Karaman, Mehmet AkifObjective: Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia. Methods: The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants. Results: The patients with schizophrenia had higher MHR values (15.04 +/- 3.31 in schizophrenia patients and 12.62 +/- 2.99 in controls; p = 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR. Conclusion: To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.Öğe First manic episode induced by over the counter slimming drug that contains sibutramine(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Kokacya, Mehmet Hanifi; Sahpolat, Musa; Kurhan, FarukSibutramine, a serotonin, noradrenalin and to a lesser extent dopamine reuptake inhibitor, is a beta phenyletylamine used in obesity treatment and has many psychiatric side effects. Although, prohibited due to cardiologic side effects, it is still being sold as Slimming pills via internet. It is known that antidepressants can cause manic or hypomanic shifts. Since sibutramine has an antidepressant activity it may cause manic or hypomanic shifts. We present an adolescent who had his first manic episode after using sliming pills, which contain sibutramine, and was admitted to our service for his second manic episode 6 months after his first episode.Öğe Focusing on physical symptoms and psychological trauma of patients with bruxism(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Sahpolat, Musa; Adiguzel, Mehmet; Ari, MustafaObjective: The aim of this study is to compare physical symptoms and childhood psychological trauma levels of bruxism patients with healty controls and to establish its relevance with sociodemographic characteristics. Material and Methods: This study was conducted in Department of Psychiatry in Mustafa Kemal University, Medical School and Faculty of Dentistry on 57 patients with bruxism and on 57 healthy controls who applied to outpatient clinics and accepted to join the study. Clinical diagnosis of bruxism was made according to Rugh and Harlan's criteria of selection. Sociodemographics data sheet, Somatosensory Amplification Scale (SSAS) and Childhood Trauma Questionnaire (CTQ) were applied by clinicians. Results: The mean age of patients with bruxism was determined 28.7 +/- 9.1 years, 63.1% (n=36) were women, 56.1% (n=32) were unmarried, and 54.3% (n=31) had low socioeconomic level. The mean SSAS score of patients with bruxism was detected statistically significantly higher than that of control group, but there was no statistically significant difference in the mean CTQ value between patient and control groups. There was positive and significantly correlation between CTQ and SSAS scores. Conclusion: In our study, increased focusing on physical symptoms, and a positive correlation between psychologic trauma and physical symptoms are defined in patients with bruxism. This fiunding points out that patients with bruxism may perceive normal physical sensations as intense, annoying and noxious. It is believed that individuals with bruxism seeking medical advice from different clinics may deserve a consultation to psychiatry clinics for diagnosis and treatment to define any underlying causes.Öğe Higher prevalence of metabolic syndrome and related factors in patients with first-episode psychosis and schizophrenia: a cross-sectional study in Turkey(Taylor & Francis Ltd, 2021) Sahpolat, Musa; Ari, MustafaBackground Schizophrenia patients (SPP) have an increased risk of metabolic syndrome (MetS) and are twice more likely to experience diabetes mellitus and obesity than the general population. Aims The main purpose of this study was to assess the prevalence of MetS and its components in first-episode psychosis patients (FEPP) and SPP. Methods This study consisted a total of 38 untreated FEPP, 40 SPP and 41 randomly selected healthy volunteers admitted to the psychiatric outpatient clinic. The diagnosis of MetS was made based on Adult Treatment Panel III (ATP III), ATP III-A and International Diabetes Federation (IDF) criteria. Results The prevalence of MetS was 26.3, 28.9 and 31.5% according to ATP III, ATP III-A and IDF criteria in the FEPP, respectively. The prevalence of MetS was 37.5, 40 and 42.5% according to ATP III, ATP III-A and IDF criteria in the SPP, respectively. The prevalence of MetS was 9.7, 9.7 and 12.2% according to ATP III, ATP III-A and IDF criteria in the control group, respectively. The prevalence of MetS was higher in female patients than male patients based on all three diagnostic criteria. The MetS patients had a higher mean of age, a longer duration of disease, and treatment compared to patients without MetS. Conclusion The current study found that FEPP and SPP had an increased prevalence of MetS. Especially, clinicians should pay attention to MetS in SPP due to the presence of risk factors, such as advanced age, being female, and long duration of disease and treatment.Öğe Increased Mean Platelet Volume in Patients with Depression(Derman Medical Publ, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal Turker; Kivrak, YukselAim: It is well known that the mean platelet volume (MPV) is a good indicator of platelet activity and the incidence of cardiovascular diseases. Major depressive disorder may emerge in association with the cardiovascular diseases. In this study, we aimed to investigate the relationship between MPV and major depressive disorder. Material and Method: MPV values of 65 patients with major depression were compared with 66 age-and sex-matched healthy subjects. Body mass index (BMI), MPV, platelet count (PLC) of all participants were measured. Beck Depression Scale (BDS) was performed to measure severity of depression. Results: MPV values of patients who had major depression were found to be significantly higher than the control group. Comparing Major Depression with the control group, there was no significant difference in terms of platelet count. In the depression group, there was no correlation between the severity of depression and MPV. Discussion: As a result, the mean platelet volume was determined to have a significant increase in major depressive disorder compared with healthy individuals. This also may be informative about the association between pathologies related vascular structure such as vascular atherosclerosis and depression.Öğe Increased mean platelet volume in patients with panic disorder(Dove Medical Press Ltd, 2015) Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Kivrak, Yuksel; Ari, Mustafa; Sahpolat, Musa; Ulutas, Kemal TurkerObjective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age-and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.Öğe Investigation of obesity frequency and eating habits in a university hospital professionals(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Canbay, Ozden; Dogru, Esra; Katayifci, Nihan; Duman, Fatma; Sahpolat, Musa; Kaya, Inci; Dag, ErsinObjective: Aim of this study was to determine the incidence of obesity in health professionals and to investigate the effects of obesity on depression and physical health. Materials and Methods: Research has been applied to the medical staff and auxiliary staff of Mustafa Kemal University Research Hospital. 131 individuals were included in the study. Socio-demographic information form, New York Posture Analysis and Beck Depression Scale were applied. Body Mass Index (BMI), daily working hours, daily number of meals, perception of body image, eating habits and sleep state were examined. Results: Individuals with age between 19-60 were included in the study. 52 individuals were male, 72 of them were female. Of these individuals, 85 were married, 46 were single. A statiscally significant relationship has not been found between spending time at the dining table and obesity. Statistically significant difference has been found between BMI and perception. Also, statistically significant relationship has been found between exessive consumption of food in a meal and obesity. There has been no significant relationship between drinking water while eating meal and less chewing meals. Acidic drink consumption frequency has been found to be more in obese individuals than others. A significant difference has been found between fruit-vegetable consumption frequency and BMI. It has been observed that obese and overweight individuals consume fruits more frequently than normal and slim individuals. Frequency of consumption of sugary and fatty foods has been seen more in obese and overweight individuals than normal and weak individuals. Statistically significant difference has been found between number of meals and BMI. Conclusion: Identification of the prevalence of obesity which is a society problem with increasing importance and factors affecting obesity in healthcare workers who are the main persons fighting against the obesity are extremely important. It has been thought that obesity brings significant orthopedic problems due to postural issues. Additionally, body image perception in overweight and obese individuals result in a biopsycho- socio-cultural aspects and treatment program must be created comprehensively. Obesity causes systemic diseases, especially cardiac, diabetes and orthopedic problems, so appropriate and specific exercises should be given individually.Öğe Peripheral edema due to olanzapine use: a case report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Sahpolat, Musa; Copoglu, Umit Sertan; Kokaya, Mehmet HanifiPeripheral edema is associated with multiple medical etiologies (systemic disorders, hypoproteinemia, long-term immobility, cancer diseases) and drugs (nonsteroidal anti-inflammatory drugs, antihypertensives, steroids, and immunsupressive agents). Olanzapine is an atypical antipsychotic medication approved for treatment of schizophrenia, bipolar affective disorder and other psychiatric disorder. Olanzapine-induced side effects is also presented with weight gain, drowsiness, asthenia, constipation, dyspepsia, dry mouth, and dizziness. Olanzapine-induced edema formation mechanisms at the level of information about the ongoing assumptions and olanzapine-induced receptor is reported to be associated with the profile. In this case report, a case of olanzapine-induced peripheral edema, not known more than the other side effects of olanzapine has been presented and probable mechanisms of edema has been discussed.Öğe Plasma Apelin, Visfatin and Resistin Levels in Patients with First Episode Psychosis and Chronic Schizophrenia(Korean Coll Neuropsychopharmacology, 2020) Sahpolat, Musa; Ari, Mustafa; Kokacya, Mehmet HanifiObjective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. Results: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. Conclusion: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.Öğe The relationship between depression, anxiety, childhood trauma, quality of life and sociodemographic feature in patients with psoriasis(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2017) Sesliokuyucu, Cem; Sahpolat, Musa; Ari, MustafaObjective: One of the most common dermotological disease psoriasis is not just a dermotological problem, it brings various psychosocial problems with it. Psychological variables in psoriasis patients examined in many studies. In our study we aimed to examine depression, anxiety, life quality and childhood trauma levels of patients. Method: 70 patients who had been diagnosed with psoriasis and applicanted to Mustafa Kemal University Tayfur Ata Sokmen Faculty of Medicine Research Hospital Dermatology Department received to the study. 72 healthy volunteers constituted the control group. Psoriasis Area Severity Index (PASI), Psoriasis Function Loss Index (PFLI), Short Form-36 Quality of Life Questionnaire (SF36), Hospital Anxiety and Depression Scale (HAD), the Childhood Trauma Questionnaire (CTQ), the Sheehan Disability Scale (SDS) were performed to these people. Results: In our study, more statistically significantly depression in psoriasis group than in the healthy control group, more statistically significantly anxiety in psoriasis group than in the healthy control group were detected. Deterioration occurred in the functioning of the patients and more statistically significantly funcionality deterioration were found than in control group. More statistically significantly childhood trauma scale score in psoriasis group than in the healthy control group, When we look at the activity vitality energy subscale score, vitality subscale score, social functioning subscale scores in SF-36 subscale scores of the patient group were detected statistically significant lower than the control group. Conclusions: According to our study findings psoriasis patients' anxiety, depression, quality of life and childhood psychological trauma has significant association with psychiatric symptoms although in different studies these findings also changes but indicates that patients needed psychiatric help.Öğe Stress reaction, anxiety and depression after bomb attacks in Reyhanli in Syria-Turkey border(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Ari, Mustafa; Kokacya, Mehmet Hanifi; Copoglu, Umit Sertan; Yengil, Erhan; Kivrak, Yuksel; Sahpolat, Musa; Budak, BirsenObjective: Terror attacks are actions taken to create maximum negative psychological impact on the target population. As result of two separate bombings on 11 March 2013 at Hatay, Reyhanli 52 people died and 146 people were injured. The purpose of this study is to determine the ratio of depression, anxiety and post-traumatic stress disorder (PTSD) on sixth month following the blast in those people who were exposed to explosions either visually and auditory, and in tose who were lindirectly exposed by being witnesses. Methods: In this study 43 people who were directly exposed, 42 people who were indirectly exposed to the explosions and 45 healthy people as a control group are included for a total of 130 individuals. On sixth month after the blast Beck Depression Inventory, Civilian Versions of Post-traumatic Stress Disorder Checklist, State-Trait Anxiety Inventory and Sociodemographic Information Form were administered to all subjects. Results: The prevalence of depression, anxiety and post-traumatic stress disorder on people who directly and indirectly exposed to explosions are significantly high compared to control group. Among the three groups there are no statistically significant differences in terms of age, gender and demographic factors. Conclusions: Our study has supportive information about the individuals who were exposed to terrorist attacks have high prevalence of PTSD. Additionally, the fact that the prevalence of PTSD and depression were higher in directly exposed cases than indirectly exposed ones may be illustrative in terms of approach to terror trauma.
