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    Acitretin for Papillon-Lefevre syndrome in a five-year-old girl
    (Wolters Kluwer Medknow Publications, 2008) Bald, Didern Didar; Serarslan, Gamze; Sangun, Ozlem; Homan, Seydo
    [Abstract Not Available]
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    Acitretin treatment in acrokeratosis verruciformis of Hopf
    (Taylor & Francis Ltd, 2007) Serarslan, Gamze; Balci, Didem Didar; Homan, Seydo
    Acrokeratosis verruciformis of Hopf is a rare disorder and characterized by flesh-coloured, wart-like, flat papules on the dorsum of the hands and feet. The disease is an autosomal disorder, but sporadic cases also occur. We present a 38-year-old woman diagnosed with acrokeratosis verruciformis without family history and treated successfully with acitretin.
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    Acquired lymphangioma circumscriptum of the vulva secondary to radiotherapy
    (Int Scientific Literature, Inc, 2010) Akansu, Bulent; Atik, Esin; Altintas, Suleyman; Serarslan, Gamze; Dolapcioglu, Kenan; Canda, M. Serefettin
    Background: Lymphangioma circumscriptum is a benign lesion of the lymphatics. The primary form of the disease is generally seen at birth or during childhood, whereas the secondary (acquired) form is a result of radiotherapy or a surgical procedure. Case Reoprt: A 38-year-old female patient was admitted to hospital with the complaint of skin eruptions on her vulva. About 10 years before she had had a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of squamous cell carcinoma of the cervix and radiotherapy had been performed to the perineal region after surgery. Papillary-like lesions on the skin were seen in gross examination. These lesions were diagnosed as acquired lymphangioma circumscriptum by microscopy. Conclusions: Acquired lymphangioma is a benign lesion which can appear many years after radiotherapy. Several pre-malignant and malignant lesions can also occur following radiotherapy in this region. Therefore it is important for the clinician and pathologist to be aware of this situation and be careful when making the differential diagnosis.
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    Angioedema is an unfavorable factor for the response to omalizumab in chronic spontaneous urticaria: A retrospective study
    (Wiley, 2019) Serarslan, Gamze; Uzun, Mehmet; Dogramaci, Asena Cigdem; Celik, Ebru
    Antihistamines are the first-line treatment option for chronic urticaria. In recent years, omalizumab, an anti-immunoglobulin-E humanized monoclonal antibody, has been used in patients with recalcitrant disease. The present study aimed to retrospectively evaluate the efficacy and safety of omalizumab and determine whether there was a difference between complete and partial responses to omalizumab with respect to age, gender, disease duration and coexistence of angioedema. From May 2014 to December 2016, a total of 40 refractory chronic urticaria patients were treated with omalizumab. Complete response was observed in 19 (47.5%) patients, and partial response was observed in 18 (45%) patients. There were no statistically significant differences between the rates of complete and partial responses in patients with respect to gender, age, and disease duration. However, complete response was more frequent (60%) in patients without angioedema. Remission was observed in 40.5% (n = 15) of patients, and the follow-up time was 5.5 +/- 2.4 months. There was a statistically significant association between remission and coexistence of angioedema (p < .05). Eighty-seven percent (13/15) of the remission patients did not have angioedema. Thus, omalizumab can be used effectively and safely in refractory chronic urticaria patients. However, the coexistence of angioedema may be an unfavorable factor for complete response and remission.
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    Antakya'da ilkokul öğrencilerinde pedikülozis kapitis sıklığı
    (2004) Serarslan, Gamze; Çulha, Gülnaz; Savaş, Lütfü; Yiğit, Hakan; Akçalı, Cenk; Önlen, Yusuf; Savaş, Nazan
    Amaç: Antakya’da ilkokul öğrencilerinde pedikülozis kapitis sıklığının saptanması amaçlandı. Gereç ve Yöntemler: Altı okulun kız ve erkeklerden oluşan toplam 3935 öğrencisi pedikülozis kapitis yönünden incelendi. Okullar, iyi ve kötü olarak iki sosyo-ekonomik sınıfa göre gruplandı. Sonuçların değerlendirilmesinde ki-kare testi kullanıldı. Bulgular: Pedikülozis kapitis sıklığı toplam %17.6 olarak bulundu. Baş biti kızlarda erkeklere oranla çok daha fazla tespit edildi (X²=486.9, df=1, p<0.0001). İnfestasyon oranı sosyo-ekonomik düzeyi düşük olan grupta daha yüksek bulundu (X²= 93.97, df= 1, p<0.0001). Sonuç: Çalışmamız, pedikülozis kapitisin Antakya’da yüksek oranda olduğunu ve sosyo-ekonomik durumun infestasyon ile ilgili olduğunu göstermektedir.
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    Association of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkey
    (Termedia Publishing House Ltd, 2022) Serarslan, Gamze; Cura, Sibel Elmacioglu; Kimyon, Gezmis; Ucgul, Goekhan; Karadag, Mehmet
    Introduction: In this study, we aimed to determine the frequency of MEFV mutations in Behcet's disease (BD) and to investigate the relationship between clinical findings of the disease and the MEFV mutations. Material and methods: A total of 66 participants (30 BD patients, 36 healthy subjects) were included in this study. The MEFV gene was analyzed by using DNA sequence analysis. Results: The distribution of MEFV mutations was not significantly different between the patients and the control group (p = 0.373). However, individuals with R202Q mutation had a risk of OR 4 times (95% CI: 1.1-14.5) higher than those without the mutation (p = 0.035). The rate of vascular involvement was statistically significantly higher in patients with the mutation than in patients without the mutation (p = 0.005). Conclusions: MEFV mutation was associated with vascular involvement in patients with BD. This is also the first study to indicate that the R202Q mutation may have a role in BD. However large series from different regions are required to compare these results.
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    Atypical pityriasis rosea mimicking annular lichen planus
    (Dermatologia Pediatrica, 2010) Serarslan, Gamze; Atik, E.; Sarikaya, G.
    Pityriasis rosea is a common papulosquamous disease seen in children and adults. Although diagnosis of classic pityriasis rosea is usuallly made by history and clinical exam alone, in atypical cases diagnosing may be problematic. The disease may display atypical clinical features such as in morphology, size, distribution, number, and site of the lesions. We present a 7-year-old boy diagnosed as pityriasis rosea with atypical morphology and distribution. There were annular lichen planus like lesions and less commonly papular lesions about 0.5-3 cm in size on the face, forearms and dorsal part of his hands. To our knowledge this type of morphology had not been reported to date.
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    Audiological and transient evoked otoacoustic emission findings in patients with vitiligo
    (Sage Publications Ltd, 2010) Aslan, Sundus; Serarslan, Gamze; Teksoz, Emel; Dagli, Safak
    OBJECTIVE: To investigate hearing loss in patients with vitiligo. STUDY DESIGN: Case-control study. SETTING: University hospital. SUBJECTS AND METHODS: Conventional pure-tone and high-frequency audiometric tests were obtained, and pure-tone average hearing thresholds were calculated for 22 consecutive cases with vitiligo and 22 sex- and age-matched controls. Transient evoked otoacoustic emission testing was also performed. RESULTS: There was sensorineural hearing loss on pure-tone audiogram in 16 (36.4%) ears in patients with vitiligo. The hearing thresholds (in dB) were 16.02 +/- 6.61 versus 12.39 +/- 6.05, 15.68 +/- 6.34 versus 13.18 +/- 3.75, 15.80 +/- 13.93 versus 7.39 +/- 6.95, 25.11 +/- 17.40 versus 15.91 +/- 12.91, 29.89 +/- 18.57 versus 17.84 +/- 12.36, and 45.91 +/- 23.31 versus 33.86 +/- 15.99 in the patient and control groups at 0.25, 1, 4, 8, 10, and 12.5 kHz, respectively, and were statistically significantly different. Reduction of transient evoked otoacoustic emission amplitude was statistically significant at 4 kHz in patients with vitiligo (6.34 +/- 3.98 dB vs 8.63 +/- 5.15 dB, P = 0.023). There was no significant difference in reproducibility, stimulus intensity, stability, and average transient evoked otoacoustic emission amplitudes in patients with vitiligo. CONCLUSION: Hearing thresholds at pure-tone and high-frequency audiometry were higher in patients with vitiligo. Also, significantly lower high-frequency amplitudes were recorded during transient evoked otoacoustic emission testing in the disease group. (c) 2010 American Academy of Otolaryngology Head and Neck Surgery Foundation. All rights reserved.
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    Baboon Syndrome Induced by Amoxycillin
    (Turkish Soc Dermatology Venerology, 2006) Serarslan, Gamze; Atik, Esin
    Baboon syndrome is a rarely seen type of systemic contact dermatitis and characterized by erythema of the gluteal and genital area and in the flexural areas. Baboon syndrome occurs after ingestion or systemic absorption of contact allergen in individuals previously sensitized by topical exposure to the same allergen. However, this eruption may occur with drugs taken systemically without previous sensitization. It is also an uncommon condition in children. We report a 9-year-old patient with Baboon syndrome induced by amoxycillin without known previous sensitization.
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    Benin, premalin ve malin lezyonlarda hücre proliferasyon belirleyicilerinin ekspresyonu ve insan papilloma virus izolasyonu
    (2007) Serarslan, Gamze; Atik, Esin; Otlu, Barış; Bakariş, Sevgi; Durmaz, Rıza
    AMAÇ: Bu çalışmada çeşitli benin, premalin ve malin deri lezyonlarında proliferasyon belirleyicilerinin rolü ve bu lezyonlarda insan papilloma virusu (HPV) pozitifliğinin saptanması amaçlandı. GEREÇ-YÖNTEM: Çalışmaya, parafin bloktaki 62 doku [12 seboreik keratoz (SK), 10 keratoakantom (KA), 8 aktinik keratoz (AK), 22 bazal hücreli karsinom (BHK) ve 10 skuamöz hücreli karsinom (SHK)] alındı. Doku örnekleri, Ki-67, p21 ve bcl-2 ekspresyonunu belirlemek amacıyla, immünohistokimyasal yöntemle çalışıldı. HPV DNA’sını tespit etmek için PCR uygulandı. BULGULAR: BHK tanısı almış olan iki dokuda HPV (tip-16) pozitifliği saptandı. Lezyonlarda Ki-67, p21 ve bcl-2 ekspresyonu sırası ile şu şekildeydi: KA
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    Blaschko çizgileri dağılımlı iki lineer liken planus olgusu
    (2008) Serarslan, Gamze; Hakverdi, Sibel
    Liken planus, deri ve mukozaları tutabilen, inflamatuar bir deri hastalığıdır. Lineer liken planus, liken planusun nadir görülen bir formudur ve tüm liken planuslu hastaların yaklaşık %0.2’sini oluşturur. Alt ekstremitede lineer liken planus lezyonu olan ve Blaschko çizgileri boyunca dağılım gösteren iki olgu sunmaktayız.
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    Clinical characteristics and treatment outcomes in patients with urticarial vasculitis
    (Kare Publ, 2021) Serarslan, Gamze; Okyay, Ebru
    OBJECTIVE: Urticarial vasculitis (UV) is an uncommon disease clinically presenting with pruritic urticarial plaques of the skin. The disease is classified as normocomplementic and hypocomplementemic types according to their complement levels. We aimed to evaluate demographic characteristics, laboratory findings, and response to treatment of patients diagnosed as UV in our clinic. METHODS: Between January 2015 and January 2019, the files of the patients were retrospectively reviewed. Demographic data, clinical features, laboratory findings, suspected triggering factors, disease course, treatment modalities, and treatment results of the patients were recorded. RESULTS: A total of 16 patients (nine males [56.25%], seven females [43.75%]) were included in the study.The mean age at diagnosis was 45.2 +/- 10.4 years and the duration of the disease was 72.1 +/- 62 months. Twelve (75%) patients had angioedema and two (12.5%) patients had residual hyperpigmentation. The most common extracutaneous finding was arthralgia (43.7%). No hypocomplementemia was detected in the patients. The most common abnormal laboratory findings were CRP elevation (37.5%) and ANA positivity (n=4/15, 26.7%). Analgesic and antibiotic drugs use were the most common possible triggering factors for the disease (n=9, 56%). Oral antihistamines, oral corticosteroids, azathioprine, colchicine, dapsone, hydroxychloroquine, doxepin, and omalizumab were among the treatments given to the patients. Complete remission was achieved in three patients. CONCLUSION: Compared with other studies, we found that angioedema was more frequent, postinflammatory hyperpigmentation was lower and long-term treatment was needed to control UV attacks. There are a few studies on UV and we think that more and larger patient groups are needed for standardization of treatment.
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    Çocuklarda kutanöz mastositoz : Demografik, klinik ve histopatolojik bulgular
    (2008) Serarslan, Gamze; Atik, Esin; Canda, Şerafettin
    Amaç: Mastositoz, bir veya daha çok organda mast hücrelerinin çoğalması ve birikmesi ile karakterize bir hastalıktır. Deri, en sık tutulan organdır. Bu çalışmada kutanöz mastositozu olan çocuk hastaların demografik, klinik ve histopatolojik bulgularının sunulması ve literatürün gözden geçirilmesi amaçlandı. Yöntemler: Kutanöz mastositoz tanısı alan 14 çocuk hastanın demografik, klinik ve histopatolojik verileri geriye dönük olarak analiz edildi. Bulgular: On bir hastada (%78.6) ürtikerya pigmentoza, iki hastada (%14.3) mastositoma ve bir hastada (%7.1) ürtikerya pigmentoza ve mastositoma birlikteliği vardı. Hastaların %64.3’ünde hastalık hayatın ilk bir yılı içerisinde başlamıştı. Erkek-kız oranı 1:1.8 idi. Ürtikerya pigmentozalı hastalarda lezyonlar en sık gövde ve ekstremite yerleşimli, mastositomalı hastalarda ise gövde yerleşimliydi. Darier işareti hastaların %92’sinde bulunmaktaydı. Aile öyküsü olan bir olgu vardı. En sık saptanan şikayet kaşıntı idi. Sonuç: Sonuçlarımız, kızların sayısındaki üstünlük dışında genel olarak daha önce bildirilen çalışmalar ile uyumluydu.
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    Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy
    (2015) Serarslan, Gamze; Aksakal, Metin
    Cutaneous leishmaniasis is a protozoan infectious disease and widespread in Mediterranean basin including Turkey. Lesions usually start with erythematous papules, gradually enlarges and afterwards it ulcerates. We present a 12-year-old boy with diffuse persistent lip swelling mimicking granulomatous cheilitis. Systemic glucantime was started. However, severe hypotension and bradycardia was developed after injection. Oral fluconazole was started and the lesion resolved completely. Cutaneous leishmaniasis can have varied clinical manifestations and should be suspected especially in endemic areas. Oral fluconazole seems to be safe and effective treatment modality in paediatric cases.
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    Cutaneous leishmaniasis secondarily infected by Gemella haemolysans
    (2008) Serarslan, Gamze; Çetin, Meryem
    Gemella haemolysans nadir tespit edilen, fakültatif anaerob, Gram pozitif, kokoid şekilli bir organizmadır ve ağız boşluğu, üst solunum yolu, gastrointestinal yol ve genitoüriner yolun normal florasında bulunur. Kutanöz layşmanyazis, Leishmania parazitinin neden olduğu infeksiyöz bir hastalıktır. Bu makalede kutanöz layşmanyazis lezyonunun Gemella haemolysans ile sekonder olarak infekte olduğu yirmi yaşında bir erkek hasta sunulmuştur.
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    Delayed Diagnosis: Giant Basal Cell Carcinoma of Scalp
    (Deri Zuhrevi Hastaliklar Dernegi, 2008) Balci, Didem Didar; Serarslan, Gamze; Hakverdi, Sibel
    Although basal cell carcinoma (BCC) is the most common form of skin cancer, the scalp lesions of BCC have been rarely reported. Giant BCC is defined as a tumor larger than 5 cm in diameter and only 0.5-1% of all BCCs achieve this size. We report a case of giant BCC on the scalp that was treated with topical coticosteroids and antifungal shampoo for five years. BCC should be considered in the differential diagnosis in erythematous plaque type lesions resistant to therapy with long duration localized on the scalp. (Turkderm 2008; 42: 67-9)
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    Dermoscopy in the Diagnosis of Cutaneous Leishmaniasis
    (Int Dermoscopy Society, 2019) Serarslan, Gamze; Ekiz, Ozlem; Ozer, Cahit; Sarikaya, Gokhan
    Background: Cutaneous leishmaniasis (CL) is a protozoan infectious disease. Dermoscopy is a noninvasive diagnostic tool that has been applied to several skin diseases, including infestations. Objectives: To determine the dermoscopic patterns of CL lesions and to investigate whether a relationship exists between dermoscopic characteristics and the disease duration, localization, and type of CL lesions. Methods: Seventy-nine patients (48 male, 31 female) from Hatay, Turkey, were enrolled in the study and a dermoscopic evaluation was performed on 139 lesions. Images of CL lesions were taken via polarized light contact dermoscopy. Chi-square and Fisher exact tests were used for statistical analyses and P values <0.05 were considered significant. Results: Generalized erythema was seen in all CL lesions. Vascular structures (94.2%), yellow tears (75.5%), and a white starburst-like pattern (58.3%) were the other most common dermoscopic features. Hyperkeratosis (P = 0.001) and white starburst-like pattern (P < 0.001) were more prevalent in the extremities than elsewhere. Among vascular structures, linear irregular (45.8%), hairpin (43.5%), and comma-shaped (25.9%) patterns were the most common dermoscopic findings. Linear irregular (P = 0.023) and arborizing vessels (P = 0.001) were observed in the head-neck region. Dotted (P = 0.009), hairpin (P < 0.001), and glomerular-like (P = 0.016) morphological findings were more prevalent in the extremities. Statistical significances in disease duration were detected in microarborizing (P = 0.027) and arborizing (P = 0.004) vessels and were most prevalent with a disease duration of >6 months. Hairpin vessels were prevalent in the plaque and nodulo-ulcerative type of lesions. Dotted vessels were most commonly seen in the plaque type (47.4%) of lesions. Conclusions: Generalized erythema, yellow tears, and starburst-like patterns, as well as linear irregular, hairpin, comma-shaped, and arborizing vessels, were the most commonly detected dermoscopic features of CL lesions. We suggest that the presence of these features can be helpful when diagnosing CL lesions by dermoscopy.
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    Effect of Caffeic Acid Phenethyl Ester on Plasma Lipid Peroxidation, Antioxidant Status and Nitric Oxide Levels in Incisional Wound Model
    (Deri Zuhrevi Hastaliklar Dernegi, 2007) Serarslan, Gamze; Altug, Muhammed Enes; Kontas, Tunay
    Background and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. Materials and Methods: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. Results: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. Conclusion: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.
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    Effect of caffeic acid phenethyl ester on plasma lipid peroxidation, antioxidant status and nitric oxide levels in incisional wound model
    (2007) Serarslan, Gamze; Altu?, Muhammed Enes; Kontaş, Tünay
    Background and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. Materials and Methods: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. Results: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. Conclusion: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.
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    Evaluation of clinical and demographic characteristics of Turkish and Syrian pediatric cutaneous leishmaniasis patients from Hatay, Turkey after the Syrian civil war
    (Termedia Publishing House Ltd, 2020) Kaya, Ozlem Makbule; Serarslan, Gamze; Dirican, Emre
    Introduction: Cutaneous leishmaniasis (CL) is a skin disease affecting all ages but especially children. Cutaneous leishmaniasis exists in Turkey, and, especially together with emigration from Syria to Turkey in recent years due to the civil war in Syria, the incidence of the disease has increased. Aim: To investigate Syrian patients (SP) and Turkish patients (TP) in the pediatric age group who were diagnosed with CL and to compare the age, gender, clinical type, number of lesions, and lesion localizations of these patients. Material and methods: We included CL patients aged 0-18 who were admitted to the outpatient clinic in the period 2015-2017 and in the first half of 2018. A total of 121 patients (SP, n = 87; TP, n = 34) were included in the study. Results: The mean ages of TP and SP were 12.06 +/- 4.47 and 8.68 +/- 5.18 years and the disease durations were 6.25 +/- 3.86 and 4.73 +/- 3.39 months respectively (p = 0.049). The total number of lesions was 247. The mean lesion number per child was 2.35 +/- 2.28 in SP, and 1.23 +/- 0.55 in TP (p = 0.002). Two and multiple lesions were significantly higher in SP (p = 0.005). It was found that the lesions were most frequently located in the head/neck (FIN) region (76.9%) and 44.1% of patients with HN localization belonged to the 7-12 age group. We also found that 57.1% of the HN lesions were of the papule type in the patients. Conclusions: We obtained similar results as in other studies in terms of age, gender, localization, and duration of lesions in general. When SP and TP were compared, we found that the number of lesions was higher, the disease duration was shorter, and the mean age was younger in SP.