Yazar "Silfeler, Dilek Benk" seçeneğine göre listele
Listeleniyor 1 - 17 / 17
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Can the ductus venosus doppler predict the hemoglobinopathies?(E-Century Publishing Corp, 2015) Karateke, Atilla; Silfeler, Dilek Benk; Gungoren, Arif; Kurt, Raziye Keskin; Okyay, Ayse Guler; Dokuyucu, Recep; Ulutas, TurkerObjective: The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (weekday) in pregnant women with hemoglobinopaties and its relation with fetal outcomes. Material and methods: A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed. Results: The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 +/- 0.7) than control group (10.67 +/- 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 +/- 1.66, 8.90 +/- 0.81, 2.97 +/- 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (beta = 1.07, P = 0.001), S/D (beta = 2.61, P = 0.001) and reverse 'a' wave (beta = 2.46, P = 0.004). Conclusion: Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.Öğe Comparison of Levels in Preterm and Term Neonates Mean Platelet VolumePreterm(Derman Medical Publ, 2013) Silfeler, Ibrahim; Dorum, Bayram Ali; Silfeler, Dilek Benk; Arica, SecilGunherAim: One of the determinants of the functions of platelets and average platelet volume. In our study, preterm newborns with Mean Platelet Volume levels and term newborns with MPV levels are compared. Material and Method: The results of hemogram of a total of 138 newborns (80 preterm and 58 term), which were born in Hospital and have no problem with any other metabolic hematological were evaluated retrospectively. MPV values were compared by statistical analysis. Results: When the MPV values of Term newborns and preterm newborns were compared, The difference was highly statistically significant. Discussion: While the MPV of the sick preterm newborns were assessed, it should not be forgotten that the MPV level of healthy premature babies were higher the MPV level of term newborns. This difference is probably due to the increase in the production of young platelets.Öğe Does Polycystic Ovary Syndrome Itself Have Additional Effect on Apelin Levels?(Hindawi Ltd, 2014) Silfeler, Dilek Benk; Gokce, Cumali; Kurt, Raziye Keskin; Atilgan, Nigar Yilmaz; Ozturk, Oktay Hasan; Turhan, Ebru; Baloglu, AliObjective. The present study was designed to compare serum levels of apelin between lean PCOS women and healthy women with regular menses. Study Design. A total of 30 lean patients with PCOS and 30 healthy subjects were included in this study. Serum apelin levels were compared between groups. Results. Serum apelin levels in lean PCOS patients were not significantly different from the control subjects. Conclusion. Our findings indicate that PCOS itself does not seem to change apelin levels. Further investigation on a large number of subjects will need to be conducted to prove the consistent or variable association in PCOS.Öğe Does the presence of anhydramnios affect the duration of medical abortion?(Via Medica, 2016) Karapinar, Oya Soylu; Gungoren, Arif; Dolapcioglu, Kenan; Silfeler, Dilek Benk; Kurt, Raziye Keskin; Sahin, Hanifi; Hakverdi, Ali UlviObjectives: The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. Material and methods: Patients who were admitted to our clinic because of medical abortion between January 2010-December 2013 were included in this retrospective study. A total of 32 pregnant women with anhydramnios (study group) and 67 pregnant women with normal amniotic fluid volume but with fetal abnormality (control group) were included in the study. Patient age, gravidity, parity, gestational age, previous delivery route, and duration of the abortion were recorded. Results: Mean duration of the abortion in the study group was 71.93 +/- 47.51 h as compared to 79.08 +/- 52.62 h in the control group. There were no statistically significant differences between the two groups in terms of duration of the abortion (p = 0.516). Also, we found no statistically significant differences in duration of the abortion with regard to previous delivery route (p = 0.220). Conclusions: There were no statistically significant differences between the study group and controls in terms of duration of the abortion. In addition, neither parity nor previous delivery route affected the duration of the abortion.Öğe The effect of molar pregnancies on platelet parameters(Taylor & Francis Inc, 2016) Karapinar, Oya Soylu; Silfeler, Dilek Benk; Dolapcioglu, Kenan; Kurt, Raziye Keskin; Beyazit, AhmetThe aim of this study was to compare platelet parameters between abortus groups with gestational trophoblastic disease (GTD) (molar pregnancy, invasive mole, choriocarcinoma, etc) and without disease according to pathological result. The study population consisted of patients with GTD (n=53) and aborted patients without disease as a control group (n=53) who were seen in our clinic between January 2010 and December 2013. In this retrospective study, age, gravidity, levels of haemoglobin, white blood cell count, platelets, platelet parameters (mean platelet volume (MPV), platelet distrubition width (PDW), platelet crit (PCT), which shows platelet functions were recorded. The pathological diagnosis of GTD was recorded. The mean platelet count, MPV, PDW and PCT levels were similar between the groups. There is no statistically significiant difference between types of GTN in these parameters according to pathological diagnosis. According to our study results, platelet count and levels of MPV, PDW ve PCT in GTD patients were similar to aborted patients without disease.Öğe Evaluation of hemoglobinopathy screening results of a six year period in Turkey(Drunpp-Sarajevo, 2012) Arica, Secil Gunher; Turhan, Ebru; Ozer, Cahit; Arica, Vefik; Silfeler, Dilek Benk; Silfeler, Ibrahim; Altun, Ayse BetulBackground and Objectives: Hemoglobinopathies are autosomal recessive inherited diseases more commonly seen in Mediterranean countries. Hereditary blood diseases including Bthalassemia and sickle cell anemia are important health problems. In our study we aimed to analyze the results of the premarital hemoglobinopathy screening test for a 6 years period in Hatay region. Material and Methods: The study sample comprised the couples attending to the Mother and Child Health Care Center in Hatay for premarital hemoglobinopathy screening from 2004 to 2009. Hemoglobin chain analyses of 87.830 couples were evaluated. Results: 175.660 people were screened at total. The prevalence of beta thalassemia trait, sickle cell anemia trait, sickle cell anemia, beta thalassemia major, beta-thalassemia intermedia, alphathalassemia, alpha-thalassemia trait was found as 13.921 (7,9%), 6.074 (3,4%), 631 (0.35%), 132 (0.07%), 118 (0.06%), 9 (0.005%), 150 (0.08%) respectively. 72 newborns with betathalassemia were diagnosed as a result of the marriage of the carrier couples in 6 years. Conclusions: Hatay is a high risk region for beta-thalassemia and sickle cell anemia trait. In countries with high prevalence of hemoglobinopathies, a premarital screening program and counseling is needed to decrease the prevalence.Öğe Evaluation of Mean Platelet Volume values in lean women with polycystic ovary syndrome(Professional Medical Publications, 2014) Silfeler, Dilek Benk; Kurt, Raziye Keskin; Yengil, Erhan; Un, Burak; Arica, Secil; Baloglu, AliObjective: Mean Platelet Volume (MPV) is an important indicator of platelet activation. It is known that MPV increases in patients with coronory artery disease, diabetes mellitus, atherosclerosis and Polycystic ovary syndrome (PCOS). Our aim was to measure the MPV in lean patients with polycystic ovary syndrome. Methods: The present study was designed to examine the platelet function by measuring MPV in non-obese women with PCOS. A total of 50 outpatients with PCOS were included. The control group consisted of 50 healthy subjects. Serum platelet, MPV, and white blood cell (WBC) levels were compared and evaluated retrospectively in all participants. These values were compared by statistical analysis. Results: There were no statistically significant difference in between groups regarding MPV (p=0.357), WBC (p=0.414) and platelet (p=0.666). Conclusion: There are studies implying MPV increase in PCOS patients, in our patients MPV levels did not correlate with PCOS except for patients with obesity. We think that PCOS itself has no effect on MPV levels and obesity changes MPV levels.Öğe The incidence of preeclampsia in Intra-Cytoplasmic Sperm Injection pregnancies(Professional Medical Publications, 2014) Ulkumen, Burcu Artunc; Silfeler, Dilek Benk; Sofuoglu, Kenan; Silfeler, Ibrahim; Dayicioglu, VedatObjective: We aimed to evaluate the association between infertility etiology in Intra-Cytoplasmic Sperm Injection (ICSI) pregnancies and preeclampsia; besides, we aimed to discuss the effect of the paternal factor in the pathogenesis of preeclampsia. Hypothesis: We hypothesized that preeclampsia is more common in ICSI pregnancies with male factor. It is known that maternal exposure to paternal sperm cells over a time period has a protective effect against preeclampsia. Male partners with azospermia have no sperm cells in their seminal fluid, whose female partners will not be able to develop some protective immunity against preeclampsia. We hypothesized that the infertile couples with male factor (partner with azoospermia and also oligospermia) would be an ideal model to test the partner-specific protective immunity against preeclampsia, as the women had no chance to develop adequate protective immunity via the partner's sperm exposure. Methods: This Single-center, retrospective study included 508 infertile couples admitted to our IVF center between January 2001 and March 2008. The data regarding the maternal age, etiology of the infertility, the pregnancy rates, abortus ratio and viable pregnancy rates was collected from the case files. Antenatal complications such as preeclampsia, placenta previa, abruptio placenta, premature rupture of membranes, premature labor, oligohydramnios, gestational diabetes, postmaturity, postpartum complications and neonatal outcomes were evaluated via the file records and phone interviewing. The study population was divided into two main groups according to the etiology of infertility. 301 of the study population (group 1) was infertile due to male factor and 207 of the study population (group 2) was female factor and unexplained infertility cases. Group 1 patients were divided further into two subgroups: group 1a included 56 cases in which TESE (testicular sperm extraction) was used to obtain the sperm cells as the male factor was severe and as there was no sperm cells in seminal fluid. Group 1 b consists of 245oligospermic cases who obtained sperm cells via conventional methods. Results: The mean ages of women in Group one and two were 30.22 +/- 5.06 and 31.58 +/- 4.36 years respectively (p=0.001). 129 cases (42,8%) from group one and 106 cases (51,2%) from Group two ended in first trimester and early second trimester (<24 gestational weeks) pregnancy loss. In group one, only 172 cases of 301 pregnancies passed over 24 weeks of gestational age, whereas in group two, 101 cases of 207 patients passed over 24 gestational weeks. There was no significant difference between two groups regarding chemical pregnancies and early pregnancy loss (p= 0.314). There was no significant difference between the groups regarding placenta previa, gestational diabetes, oligo hydramnios and intrauterine growth retardation. One one pregnancy was 1.5 times more vulnerable for preeclampsia. Conclusion: Pregnancies with azoospermic and oligospermic partners had an increased risk for developing preeclampsia.Öğe Increased Density of Demodex folliculorum Mites in Pregnancies with Gestational Diabetes(Karger, 2014) Kurt, Raziye Keskin; Kaya, Ozlem Aycan; Karateke, Atilla; Silfeler, Dilek Benk; Karapinar, Oya Soylu; Akkoca, Ayse Neslin; Hakverdi, Ali UlviObjective: To investigate the presence of Demodex in patients with gestational diabetes and the impact of glucose regulation on Demodex density in gestational diabetes. Subjects and Methods: The study population consisted of 33 patients with gestational diabetes and 30 pregnant women without gestational diabetes (control group). The age, parity, gestational age, and BMI of the study group were recorded and the patients were divided into 2 groups, i. e. those with regulated and unregulated glucose levels, according to their postprandial 1st-and 2nd-hour glucose values. A standardized skin surface biopsy method was used to determine if patients had Demodex folliculorum infestation (> 5 mites/cm 2 of skin). Results: Patients with gestational diabetes had a statistically significantly higher Demodex density compared to the control group (24.2 vs. 3.3%; p < 0.001). Furthermore, a significantly higher proportion of gestational diabetes patients with unregulated glucose levels had a higher Demodex density compared to those in the regulated subgroup (6/19 vs. 2/14; p = 0.001). Conclusion: Our study revealed that the Demodex density was increased in gestational diabetes patients. Further, poor glucose regulation could be the mechanism responsible for the increased Demodex density in gestational diabetes patients with unregulated glucose levels compared to those with regulated glucose levels. (C) 2014 S. Karger AG, BaselÖğe Investigation of the presence of Trichomonas vaginalis in infertile Turkish women(Walter De Gruyter Gmbh, 2015) Kaya, Ozlem Aycan; Silfeler, Dilek Benk; Kurt, Raziye Keskin; Gozukara, Ilay; Yengil, Erhan; Bayramoglu, NeslihanBackground: Trichomoniasis is a sexually transmitted vaginal infection caused by a protozoan called Trichomonas vaginalis. Its prevalence ranges between 3-40% among randomly tested women. Objectives: To investigate the presence of T vaginalis in infertile women presenting to a Turkish gynecology outpatient clinic using parasitological methods. Methods: The study population comprised 51 patient participants who attended the gynecology clinic of Mustafa Kemal University Hospital between March and August 2013. The women were divided into those presenting with infertility (n = 22) and a patient control group (n = 29). Women in the control group had complaints other than infertility. Microscopic examination, Giemsa staining, and cysteine peptone liver maltose culture were performed on samples taken from posterior fornix tested for T vaginalis. Results: T vaginalis was observed in 18% (n = 4) of infertile patients and in none of the control group (P = 0.03). Conclusions: Asymptomatic infertile women should be examined for T vaginalis infection, which may play a role as a cause or contributing factor in infertility.Öğe Isolated labial fusion as a cause of acute urinary retention in early adolescent period(Professional Medical Publications, 2011) Silfeler, Dilek Benk; Artunc, Burcu; Pektas, Osman Zeki; Sanverdi, Ilhan; Eren, SadiyeFusion of the labia majora is generally an acquired defect because of local inflamation, trauma and vaginal lacerations. In postmenauposal period, it is associated with lichen sclerosis. It is typically found in young neonates or prepubertal girls when the labia and vagina are not adequately estrogenized. In this study, a 14-year adolescent with labial fusion as a cause of acute urinary retention is presented.Öğe Mature cystic teratomas in our series with review of the literature and retrospective analysis(Springer Heidelberg, 2012) Ozgur, Tumay; Atik, Esin; Silfeler, Dilek Benk; Toprak, SerhatMature cystic teratomas are the most common benign ovarian neoplasms. Our aim is to analyse these cases by pathologic and clinical findings in our centre with the view of updated knowledge. In our study, 50 case reports diagnosed as mature cystic teratoma (or dermoid cyst) in Mustafa Kemal University Pathology Laboratory between 2005 and 2010 have been reviewed. Of 50 cases, the findings on mature cystic teratomas were as follows: the number of tumours located at the right ovary was 22, the left ovary, 23, with 5 cases bilaterally. Age range was 14-58 with mean rate 35.4. In two cases, tumour markers were high, one case presented with torsion; one case was obtained incidentally during delivery. Mature cystic teratomas are benign neoplasms with low malign transformation rate. Our series are low in number but our findings show the dynamic nature of these tumours.Öğe Protective Effects of Colchicine in an Experimental Rat Endometriosis Model: Histopathological Evaluation and Assessment of TNF-? Levels(Sage Publications Inc, 2015) Kurt, Raziye Keskin; Pinar, Neslihan; Karateke, Atilla; Okyay, Ayse Guler; Silfeler, Dilek Benk; Albayrak, Aynur; Ozdemir, SeydaObjective: Endometriosis is an estrogen-dependent chronic inflammatory disease observed in reproductive period. The aim of the present study is to assess the efficacy of colchicine, widely used to treat many inflammatory diseases, in an experimental rat endometriosis model. Study Design: Experimental endometriosis was constituted with implantation of autogenous endometrial tissue. Rats were divided randomly into 2 groups as colchicine group (n = 8) and control group (n =8). Although oral 0.1 mg/kg colchicine was administered 4 weeks to the colchicine group, the same amount of saline solution was administered to the control group. Before and after 30 days of treatment period, peritoneal and tissue tumor necrosis factor (TNF-), the volumes and histopathological properties of the implants were evaluated. Results: Although the implant volume decreased significantly in the colchicine group (89.2 13.4 mm(3) to 35.2 +/- 4.5 mm(3), P < .05), the implant volume increased in the control group (85.1 +/- 14.2 mm3 to 110.3 +/- 10.5 mm(3), P < .05). When compared to the control group, the colchicine group had significantly lower histopathologic sores (1.4 +/- 0.2 vs 2.6 +/- 0.4, P < .001). Although peritoneal fluid TNF- levels were significantly decreased in the colchicine group (45.2 +/- 5.3 pg/mL vs 12.1 +/- 5.2 pg/mL, P < .001), the peritoneal fluid TNF- levels were significantly increased in the control group after the treatment (44.2 +/- 3.5 pg/mL vs 61.3 +/- 12.2 pg/mL; P < .001). Tissue TNF- levels were significantly lower in the colchicine group when compared to the control group (45.4 +/- 8.6 pg/mL vs 71.3 +/- 11.2 pg/mL; P < .001). Conclusion: Colchicine resulted in regression of endometrial implant volumes in experimental rat endometriosis model and decreased peritoneal and tissue TNF- levels.Öğe Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum(Via Medica, 2014) Kurt, Raziye Keskin; Guler, Ayse; Silfeler, Dilek Benk; Ozcil, Mustafa Dogan; Karateke, Atilla; Hakverdi, Ali UlviObjectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy-Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69 +/- 1.81 vs 1.97 +/- 1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95 +/- 2.2 vs 0.56 +/- 0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.Öğe Relationship of Red Cell Distribution Width With the Presence and Severity of Preeclampsia(Sage Publications Inc, 2015) Kurt, Raziye Keskin; Aras, Zinnur; Silfeler, Dilek Benk; Kunt, Cigdem; Islimye, Mine; Kosar, OzlemAim: Although the relationship between red cell distribution width (RDW) and hypertension has been well documented, there is an absence of data on the association between RDW and preeclampsia. In the present study, we have aimed to investigate the correlation of RDW with preeclampsia and its severity. Methods: The study population consisted of 52 (35 mild and 17 severe) patients with preeclampsia and 50 control pregnancy patients. For the entire study population, baseline RDW was measured using an automatic blood counter. Results: Although there were no significant differences between the preeclampsia group and the control group in terms of hemoglobin and platelet counts, the RDW (14.1 +/- 1.1 vs 16.9 +/- 1.7, P <.001), systolic and diastolic blood pressure, proteinuria, white blood cell, and high-sensitivity C-reactive protein levels were significantly higher in the preeclampsia group. Moreover, subgroup analysis revealed that RDW levels were significantly increased in patients with severe preeclampsia when compared to the patients with mild preeclampsia (18 +/- 1.5 vs 16.4 +/- 1.5, P <.001). Conclusion: Our study results revealed that RDW levels were associated with both the presence and the severity of preeclampsia.Öğe SEROPREVALANCE OF TOXOPLASMA IgG AMONG PREGNANT WOMEN IN THE PROVINCE OF HATAY AND CONTRIBUTION OF AVIDITY TEST TO THE DIAGNOSE(Galenos Yayincilik, 2013) Okyay, Ayfle Guler; Karateke, Atilla; Yula, Erkan; Inci, Melek; Silfeler, Dilek Benk; Motor, Vicdan KoksaldiObjective: Toxoplasma gondii, an obligate intracellular parasite, is a common zoonosis in the world and causes toxoplasmosis. The infection is usually asymptomatic and if it occurs during pregnancy it may cause congenital anomalies, miscarriage, stillbirth and premature delivery. In this study, determination of seroprevalance of Toxoplasma IgG and IgM among pregnant women in the province of Hatay was aimed. In addition, IgG avidity test was performed in subjects who had positive test results for both of the two antibodies. Design: In this study, 3340 pregnant women who admitted to the outpatient clinic of Gynecology and Obstetrics Department of Mustafa Kemal University between the years of 2007 and 2012 were included. Toxoplasma IgM and IgG antibody test results of the subjects were examined retrospectively by screening the records of microbiology laboratory of the hospital. Additionally, IgG avidity test was performed in 114 cases whose test results for both Toxoplasma IgM and IgG were positive. Main outcome measures: IgM and IgG seropositivity rates were found as 3.6% (n : 120) and 57% (n: 1910), respectively. The rate of new infection was detected with avidity test as 31%. Conclusions: Since remarkably high seropositivity rate was observed in the Mediterranean region especially in the province of Hatay, antibody testing for Toxoplasma gondii may be useful during routine examinations of women who are in this region. In addition, measures should be taken to raise awareness of hygiene in our region in terms of water and sanitation.Öğe Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary(Wiley, 2015) Kurt, Raziye Keskin; Dogan, Ayse Citil; Dogan, Murat; Albayrak, Aynur; Kurt, Sefika Nur; Eren, Furkan; Silfeler, Dilek BenkAimThe aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments. Material and MethodsExperimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into five groups as: sham (sham operated, n=7); vehicle group 1 (torsion-detorsion, n=7) with 2h ischemia and 2h reperfusion; vehicle group 2 (torsion-detorsion, n=7) with 2h ischemia and 5 days' reperfusion; zofenopril group 1 (torsion-detorsion, n=7) with 2h ischemia, 2h reperfusion and a signal dose of oral 15mg/kg zofenopril; and zofenopril group 2 (torsion-detorsion, n=7) with 2h ischemia, 5 days' reperfusion and 5 days' oral 15mg/kg zofenopril. A scoring of histopathologic evaluation was performed on the ovaries according to congestion, bleeding, edema, and cellular degeneration. Biochemical assessments included catalase, tissue malondialdehyde and protein carbonyl. ResultsCompared with the vehicle groups, histopathologic scores, tissue malondialdehyde and protein carbonyl levels, which reflect oxidative stress markers, were significantly lower in the zofenopril groups. Furthermore, catalase levels were significantly increased in the zofenopril group. ConclusionOur study results revealed that zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
