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Öğe The Effect of Fingolimod (FTY720) Treatment on Liver Enzyme Levels in Relapsing-Remitting Multiple Sclerosis Patients(2020) Tap, Duygu; Terzi, Menderes Yusuf; Duman, TaşkınAim: Multiple sclerosis (MS) is a chronic inflammatory pathology affecting the centralnervous system. Many therapeutic options have been approved against MS until today. In thisstudy, it was aimed to investigate the effect of fingolimod treatment (FT) on the liver enzymelevels of relapsing-remitting multiple sclerosis (RRMS) patients.Material and Methods: Body mass index, FT (0.5 mg/day) duration, and liver enzyme(alanine aminotransferase, ALT; gamma glutamyl transferase, GGT) levels of 102 RRMSpatients (66 female, 36 male, mean age was 40.9±10.9 years) were gathered from polyclinicrecords retrospectively.Results: The FT duration of MS patients was between 0.5 and 6 years. Increased ALT andGGT levels were detected in RRMS patients after >3 month-long FT. After FT, ALT and GGTlevels elevated in males almost 2 times higher than in females. It was observed that ALT andGGT levels increased by 1.3 and 1.5 times in females, while 1.6 and 1.9 times in males,respectively. Of the MS patients with increased transaminases post-FT, 7 (23.3%) males and8 (17.4%) females were at upper limit of normal for ALT whereas 9 (34.6%) males and 14(32.6%) females as for GGT. Age and FT duration did not affect ALT and GGT levels.Conclusion: Overall, FT elevated ALT and GGT levels of RRMS patients. Thus, it is of highimportance to monitor MS patients throughout FT. So that, we suggest tracking ALT and GGTlevels during and after FT to prevent possible liver damage or the occurrence of other systemicdiseases.Öğe The effect of fingolimod (Fty720) treatment on liver enzyme levels in relapsing-remitting multiple sclerosis patients(Duzce University Medical School, 2020) Tap, Duygu; Terzi, Menderes Yusuf; Duman, TaşkınAim: Multiple sclerosis (MS) is a chronic inflammatory pathology affecting the central nervous system. Many therapeutic options have been approved against MS until today. In this study, it was aimed to investigate the effect of fingolimod treatment (FT) on the liver enzyme levels of relapsing-remitting multiple sclerosis (RRMS) patients. Material and Methods: Body mass index, FT (0.5 mg/day) duration, and liver enzyme (alanine aminotransferase, ALT; gamma glutamyl transferase, GGT) levels of 102 RRMS patients (66 female, 36 male, mean age was 40.9±10.9 years) were gathered from polyclinic records retrospectively. Results: The FT duration of MS patients was between 0.5 and 6 years. Increased ALT and GGT levels were detected in RRMS patients after >3 month-long FT. After FT, ALT and GGT levels elevated in males almost 2 times higher than in females. It was observed that ALT and GGT levels increased by 1.3 and 1.5 times in females, while 1.6 and 1.9 times in males, respectively. Of the MS patients with increased transaminases post-FT, 7 (23.3%) males and 8 (17.4%) females were at upper limit of normal for ALT whereas 9 (34.6%) males and 14 (32.6%) females as for GGT. Age and FT duration did not affect ALT and GGT levels. Conclusion: Overall, FT elevated ALT and GGT levels of RRMS patients. Thus, it is of high importance to monitor MS patients throughout FT. So that, we suggest tracking ALT and GGT levels during and after FT to prevent possible liver damage or the occurrence of other systemic diseases. © 2020, Duzce University Medical School. All rights reserved.Öğe Fingolimod tedavisinin multipl skleroz hastalarında karaciğer enzim düzeylerine etkisi(Hatay Mustafa Kemal Üniversitesi, 2019) Tap, Duygu; Terzi̇, Menderes Yusuf; Duman, Ahmet TaşkınMultipl skleroz (MS) enflamasyon, demiyelinizasyon ve nörodejenerasyon ile karakterize otoimmün bir merkezi sinir sistemi (MSS) hastalığıdır. Hastalığın inflamatuvar fazı için birçok ilaç üretilmiştir. Bu ilaçlardan biri de fingolimoddur. Fingolimod, lenf düğümlerinden lenfosit çıkışını inhibe eden, oto-reaktif T ve B lenfositlerin MSS'ye geçişini engelleyen bir sfingosin 1-fosfat reseptör (S1PR) modülatörüdür. Relapsing remittng MS (RRMS) hastalarında yapılan çalışmalar, fingolimod tedavisinin nöroinflamatuar hastalığı azaltabildiğini ve MSS doku bütünlüğünü geliştirdiğini göstermiştir. Fingolimodun, terapötik etkilerinin yanında çeşitli yan etkiler de bildirilmiştir. Bunların arasında karaciğer enzim düzeylerine olan etkisi dikkat çekmektedir. Çalışmamızda Hatay Mustafa Kemal Üniversitesi Tıp Fakültesi Nöroloji Anabilim Dalı MS polikliniğinde RRMS tanısı ile takip edilen ve ilk kez fingolimod tedavisi başlanan hastalarda fingolimod tedavisinin, karaciğer enzimlerine etkisinin araştırılması amaçlandı. Çalışmamız retrospektif bir çalışma olup, hastanemiz poliklinik veritabanına kayıtlı MS hastalarından 102 RRMS hastasına ait, cinsiyet, yaş, fingolimod kullanım süresi ve karaciğer enzim düzeyleri (Alanin aminotransferaz (ALT), Gama glutamil transpeptidaz (GGT)) kaydedildi ve istatistiksel olarak değerlendirildi. Çalışmamızda, RRMS hastalarında 0,5 mg/gün dozunda oral fingolimod tedavisi başlandıktan en erken 3 ay sonrasında bakılan ALT ve GGT düzeylerinin, tedaviye başlanmadan önceki ALT ve GGT düzeylerine göre anlamlı derecede yüksek olduğu saptandı (p<0,001). Erkek hastalarda tedavi sonrası ortalama ALT ve GGT düzeyleri kadın hastalara kıyasla yaklaşık iki kat yüksek bulundu. Erkek hastaların %23,4'ünün ve kadın hastaların %17,9'unun ALT düzeylerinin normalin üst sınırını geçtiği, erkek hastaların %34,6'sının ve kadın hastaların ise %32,6'sının GGT düzeylerinin normalin üst sınırını geçtiği saptandı. Karaciğer enzim yükselmesi ile hasta yaşı ve fingolimod kullanım süresi arasında korelasyon bulunmadı.Öğe Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?(AVES Yayıncılık, 2019) Özen, Murat Eren; Dikmen, Miriş; Tap, Duygu; Özler, Sinan; Yılmaz, Mehmet Bertan; Urhan Küçük, MeralObjectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by either estrogen receptors. GPR30 is an alternative G protein-coupled receptor distinct from the classical estrogen recep- tors (ER αα and ER ββ ). We aimed to investigate the association between GPR30 gene SNP rs3808350 and gonadal hormone (estrogen and testosterone) levels, and their association with development of schizophrenia, in a Turkish population. Methods: A total 117 schizophrenia patients and 123 control individuals were genotyped with method Real-Time PCR. Results: In the comparison of the patients and the control group with regard to the SNP genotype and allele frequencies did not show significant differences. However, there was a significant decrease in the pre- sence of AA+AG genotypes in the patient group. There were significant differences in terms of estrogen, testos- terone. In the patient group, estrogen and testosterone levels were lower than the control group. Conclusions: This is the first study examining allele and genotype frequencies of GPR30 gene SNP rs3808350 in schizophrenia patients. Because of effects of gene polymorphisms may differ in the population from the population, we may sug- gest that role of GPR30 gene SNP rs3808350 in development of schizophrenia must be investigated in different and wider populations. (Anatolian Journal of Psychiatry 2019; 20(1):13-19)Öğe The Role of Oxidative Stress in Apoptosis and Cell Proliferation of Human Bronchial Epithelial Cells(Pleiades Publishing Inc, 2021) Ecevit, Hasret; Urhan-Kucuk, Meral; Uluca, Haluk; Tap, Duygu; Arpaci, AbdullahOxidative stress is an important pathophysiological factor in chronic respiratory diseases. Our study aimed at elucidating through which pathway oxidative stress-mediated apoptosis occurs at the gene expression level under oxidative stress in the human bronchial epithelial cell line BEAS-2B. Suitable doses and time period were detected by exposing BEAS-2B cells to hydrogen peroxide (H2O2) at different doses and time periods, and the oxidative-damaged cell culture model was designed. The treatment and control groups were compared in terms of gene expression levels determined by Quantitative Real Time Polymerase Chain Reaction. The oxidative-damaged cell model was confirmed by the spectrophotometric measurement of malondialdehyde and catalase activity (p < 0.05). Caspase-3, caspase-9, bax, and bak gene expression levels increased significantly in the treatment groups compared to the control group (p < 0.05). There were not any significant differences between the groups in terms of caspase-8, Bcl-2, and bik (p > 0.05). p53 and p21 gene expression levels were found to be significantly higher in the treatment groups (p < 0.05). H2O2-induced oxidative stress, induced apoptosis through the intrinsic pathway at gene expression level in the bronchial epithelial BEAS-2B cells was observed.Öğe Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis(Springer, 2022) Terzi, Menderes Yusuf; Okuyan, Hamza Malik; Karaboga, Ihsan; Gokdemir, Cemil Emre; Tap, Duygu; Kalacı, AydınerOsteoarthritis (OA) is a common degenerative articular disorder caused by traumatic or spontaneous factors such as genetics, obesity, and advanced age. Comprehending the pathogenic mechanism of OA ensures the development of novel disease-modifying therapeutics rather than conventional palliative drugs with undesired side effects. Urotensin-II (UII) is a multifunctional short cyclic peptide implicated in several disorders. We aimed to analyze the effects of intraarticular UII treatment in a monosodium iodoacetate (MIA)-induced OA rat model. We divided animals into six groups to test three different concentrations of UII with histopathological and immunohistochemical analyses of bone morphogenetic protein-2 (BMP-2), nuclear factor kappa B subunit 1 (NF-kappa B), and intrinsic UII expression. We analyzed serum levels of cartilage related and inflammatory markers post-OA. We observed a noticeable amelioration of the MIA-induced knee damage in UII-treated animals after gross morphology examination. Mankin scoring after histopathological stainings revealed a partial prevention of articular tissue damage in UII-treated animals. We found a significant reduction in BMP-2 and NF-kappa B while an increase in intrinsic UII expressions upon exogenous UII injection after immunohistochemical analyses. The Mankin scores were significantly correlated with BMP-2, NF-kappa B, and intrinsic UII levels. There was no significant alteration in serum markers after UII treatment. We are the first group showing the protective effect of UII on the destructed knee joints of osteoarthritic rats by downregulating the BMP-2 and NF-kappa B and upregulating intrinsic UII expressions. To uncover the mechanistic role of UII during OA, further experiments are warranted. [GRAPHICS] .Öğe Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis (vol 28, 140, 2022)(Springer, 2024) Terzi, Menderes Yusuf; Okuyan, Hamza Malik; Karaboga, Ihsan; Gokdemir, Cemil Emre; Tap, Duygu; Kalacı, Aydıner[Abstract Not Available]
