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Acetaminophen reduces acute and persistent incisional pain after hysterectomy
(Edizioni Luigi Pozzi, 2018) Koyuncu, Onur; Hakimoglu, Sedat; Ugur, Mustafa; Akkurt, Cagla; Turhanoglu, Selim; Sessler, Daniel; Turan, Alparslan
OBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo. The primary outcome was incisional pain visual analog scale (VAS) at three months after surgery. The secondary outcomes were (1, 2) postoperative VAS scores while laying and sitting and (3) total patient-controlled intravenous tramadol consumption during the initial 24 hours, (4) DN4 questionnaires and (5) SF-12 at three months after surgery. RESULTS: The persistent incisional pain scores at three months were significantly lower in acetaminophen (median [121, Q3]: 0 [0, 01) as compared with saline group (0 [0, 1]) (P = 0.002). Specifically, 89%, 9%, and 2% of acetaminophen patients with VAS pain score at three months of 0, 1, and 2 or more, as compared with 66%, 23%, and 10% in the saline group (odds ratio: 2.19 (95% CI: 1.33, 3.59), P = 0.002). Secondly, postoperative pain scores both laying and sitting were significantly lower in the acetaminophen group. Acetaminophen group had significantly better DN4 score and mental health related but not physical health related quality of life. CONCLUSIONS: Our results suggest that acetaminophen reduces the risk and intensity of persistent incisional pain. However, there are other mechanisms by which acetaminophen might reduce persistent pain.
Bariatric surgery has positive effects on patients' and their partners' sexual function: A prospective study
(Wiley, 2021) Gokalp, Fatih; Koras, Omer; Ugur, Mustafa; Yildirak, Ekrem; Sigva, Hakan; Porgali, Sefa B.; Tamkac, Nezih
Background Obesity has been associated with severe conditions and sexual dysfunction. Bariatric surgery has effects positively patients' sexual function. Objectives To assess the effect of bariatric surgery on sexual functions of couples. Materials and Methods The study included 57 obese patients and their sexually active partners. Male participations were assessed with the International Index of Erectile Function (IIEF) and Male Sexual Health Questionaries (MSHQ-4), and female participations were assessed with the Female Sexual Function Index (FSFI). Results There were 31 (54.4%) male patients and 26 (45.6%) female patients in the study. The median IIEF score of the male patients statistically increased postoperatively (p < 0.001). The IIEF subgroup areas were found to have increased after surgery. The median FSFI score of the female patients statistically increased postoperatively (p < 0.001). The median FSFI of male patients' partners significantly increased postoperatively (p < 0.001). All FSFI domains were statistically significantly increased (p < 0.001, all areas). The median IIEF value of the postoperative partners of the female patients also increased statistically significant (p < 0.001). In addition, the increases in the IIEF's subdomains in terms of sexual desire (p < 0.001), intercourse satisfaction (p < 0.001), and general satisfaction (p < 0.001) were statistically significant. Conclusion The sexual functions of both males and females and also their' partners were improved after bariatric surgery. Patients with preoperative poor sexual function achieve significant benefits over patients without sexual dysfunction.
Colon Perforations Causing Morgagni Hernia Case
(Derman Medical Publ, 2014) Ugur, Mustafa; Akkucuk, Seckin; Oruc, Cem; Kayali, Alperen; Aydogan, Akin
Herniation of the intraabdominal organs through a diaphragmatic defect that occurs due to the joining anomaly of the sternal and costal segments of diaphragm is known as Morgagni Hernia. Although most of the patients with Morgagni Hernia are asymptomatic, intestinal obstruction, incarceration and strangulation can rarely occur. An 83 years old female patient admitted with acute abdomen to our clinic. Morgagni hernia was detected with preoperative thoracic and abdominal computed tomography. We aimed to present our management in Morgagni Hernia in this study.
Colonoscope incarceration in an inguinal hernia: a complication of colonoscopy
(Georg Thieme Verlag Kg, 2015) Tas, Adnan; Oruc, Cem; Olmez, Sehmus; Sahan, Mustafa; Ugur, Mustafa; Hakimoglu, Sedat; Demir, Mehmet
[Abstract Not Available]
Comparison of ethanol and hypertonic saline as a single intracystic agent in the percutaneous treatment of liver hydatid cysts
(Springer, 2023) Kayali, Alperen; Ugur, Mustafa
Purpose In this study, the effects of hypertonic saline and ethanol as a single intracystic agents in the percutaneous treatment of liver hydatid cysts were compared.Methods The 50 patients were separated into two groups as those administered 30% hypertonic saline alone as the intracystic agent in percutaneous treatment (33 patients, 52 cysts), and those administered 96% ethanol alone (17 patients, 26 cysts). Both groups were compared in terms of percentage of cyst volume reduction, complications, and treatment success.Results The follow-up period was median 17.0 months (11.0-20.0) in the ethanol group and 17.0 (14.0-22.0) in the hyper tonic saline group (p = 0.269). Complications were observed in 5 (19.2%) cysts applied with ethanol as the intracystic agent and in 7 (13.5%) of the cysts where hypertonic saline was used (p = 0.521). Clinical success was evaluated as 100% in both groups. The percentage of cyst volume reduction according to the initial volume was determined as mean 75.6 +/- 20.43 (28.19-98.13) in the ethanol group cysts and as 68.2 +/- 16.45 (26.39-97.48) in the hypertonic saline group (p = 0.427).Conclusion The results of this study demonstrated similar efficacy of hypertonic saline and ethanol in the percutaneous treatment of CE1 and CE3A liver hydatid cysts. These results suggest that the use of hypertonic saline as a single intracystic agent in the percutaneous treatment of CE1 and CE3A liver hydatid cysts provides sufficient efficacy of treatment and cyst volume reduction. Nevertheless, there is a need for further prospective, randomized studies to support these findings.
Comparison of surgical procedures and percutaneous drainage in the treatment of liver hydatide cysts: a retrospective study in an endemic area
(E-Century Publishing Corp, 2014) Akkucuk, Seckin; Aydogan, Akin; Ugur, Mustafa; Yetim, Ibrahim; Davran, Ramazan; Oruc, Cem; Kilic, Erol
Introduction: Surgical procedures are still the golden standard option in the treatment of liver cystic echinococcosis. However, minimal invasive technics like percutaneous drainage are rising trends. We aimed to compare the efficacy of surgical and percutaneous options in the treatment of liver hydatidosis in an endemic area. Methods: Patients who underwent surgical or percutaneous procedures for hydatid disease between January 2007 and December 2012 were retrospectively evaluated. Recurrence rates, hospital stay time, and related factors were analyzed. Results: There were 44 (35.5%) male and 80 (64.5%) female patients in this study. Eighty two patients (Group I) had undergone surgery (66.1%) and 42 patients (Group II) had undergone percutaneous drainage (33.9%). The mean cyst size was 7.28 +/- 2.51 cm in Group I and 8.76 +/- 3.30 cm in Group II. Nine recurrences (7.3%) were detected during study. Five of the recurrences were in Group II (11.9%) and four (4.9%) of them were in Group I. The mean length of hospital stay of all patients was 5.42 +/- 3.16 days. Discussion: Percutaneous drainage techniques can be a good alternative to surgery in selected patients. In complicated cases like cystobiliary fistula, surgery is superior to percutaneous approaches. The hospital stay time, recurrence rate and postoperative complications were not enhanced when compared to percutaneous treatment in our study. Despite all controversy about the low morbidity after percutaneous treatment, surgical approach is still a preferable option in patients with liver hydatidosis when it is performed by experienced surgeons.
Comparison of Unilateral Fasciocutaneous V-Y Flap Technique with Cleft Lift Procedure in the Treatment of Recurrent Pilonidal Sinus Disease: A Retrospective Clinical Study
(Int Scientific Literature, Inc, 2018) Koca, Yavuz Savas; Yildiz, Ihsan; Okur, Selahittin Koray; Saricik, Bekir; Ugur, Mustafa; Bulbul, Mustafa Tevfik; Uslusoy, Fuat
Background: This study aimed to assess treatment outcomes of the cleft lift procedure and V-Y flap technique in the treatment of recurrent pilonidal sinus disease (PSD). Material/Methods: A total of 51 patients who underwent cleft lift procedure and 43 patients who underwent fasciocutaneous V-Y flap technique were evaluated. The demographic characteristics, previous operations, duration of symptoms, perioperative complications, duration of operation and hospital stay, duration of draining of all patients, and recurrence of PSD were recorded. Results: The mean operation time was 35.61 +/- 5.254 min in the cleft lift group (CLG) and 57.42 +/- 7.327 min in the V-Y flap group (VYFG) (p=0.001). No wound dehiscence was found in the VYFG and 5 patients (9.8%) had wound dehiscence in the CLG (p=0.035). Draining time was 1.39 +/- 0.603 days in the CLG and 2.79 +/- 0.638 days in VYFG (p=0.001). The mean hospital stay was 1.75 +/- 0.523 days in the CLG and 3.77 +/- 1.02 days in the VYFG (p=0.001). Two patients (3.9%) in the CLG had recurrence and no recurrence was reported in the VYFG (p=0.189) in the given time interval. Conclusions: Both methods in treatment of recurrent PSD can be preferred because of low complication and recurrence rates. Because no recurrence was found after the V-Y flap technique, it appears to be a preferable method despite some disadvantages.
Effect of therapeutic hypothermia on superficial surgical site infection and postoperative pain in urgent abdominal surgery
(Turkish Assoc Trauma Emergency Surgery, 2018) Kilic, Erol; Ugur, Mustafa
BACKGROUND: Although therapeutic hypothermia has been shown to be effective on surgical site infection and postoperative pain in patients undergoing elective surgery, its exact effect on emergency laparotomy remains unclear. In this study, we aimed to investigate the effect of therapeutic hypothermia on superficial surgical site infection and postoperative pain in patients undergoing urgent open abdominal surgery. METHODS: The study included 100 patients who underwent emergency open abdominal surgery from 01/01/2016 to 01/01/2017. The patients were randomly divided into two groups: therapeutic hypothermia, group I underwent cold therapy with local sterile frozen ice compress; and control group II, underwent conventional sterile compress. Age, gender, primary pathology diagnosis, size of incision, wound type and size, and duration of surgery were compared between the groups. Visual analog scale scores were determined every 3 hours, and the requirement for analgesics was assessed for each patient within 48 hours postoperatively. Both before and after 5 days of laparotomy, c-reactive protein (CRP), white blood cell count (WBC), albumin, serum total antioxidant status, and total oxidant status levels were measured, and oxidative stress index was calculated for each patient. The rates of superficial surgical site infection were compared between both groups. RESULTS: The two groups were similar in terms of age, gender, primary pathology diagnosis, size of incision, wound type and size, and duration of surgery (p>0.05). Although no significant difference was found between the groups with regards to visual analog scale scores (p>0.05), requirement for analgesics was lower in the group I compared to that in the control group (p<0.05). No significant difference was found between the groups in terms of preoperative WBC, albumin, CRP, serum total antioxidant status, total oxidant status, and oxidative stress index (OSI) levels (p>0.05). At postoperative day 5, serum total antioxidant status level was significantly higher, and OSI level was significantly lower in the group I compared to the respective levels in the control group (p<0.05). Moreover, the superficial surgical site infection rate was significantly lower in the group I (p<0.05). CONCLUSION: In patients undergoing urgent open abdominal surgery, therapeutic hypothermia led to lower requirement for analgesics and lower superficial surgical site infection rates in the early postoperative period. We consider that therapeutic hypothermia exerts this effect by elevating the serum total antioxidant status level, and decreasing the effects of inflammatory mediators and OSI.
Efficacy of ultrasound-guided percutaneous drainage in the treatment of psoas abscess
(Bayrakol Medical Publisher, 2022) Kayali, Alperen; Beyazit, Selen; Keles, Fatma Ozturk; Bal, Tayibe; Seyfettin, Ayca; Ugur, Mustafa
Aim: In this study, we aimed to evaluate the efficacy of ultrasound-guided percutaneous drainage applied to cases determined with psoas abscess, and to investigate predisposing factors and micro-organisms causing the disease.Material and Methods: Twenty-eight patients were examined, including 15 males and 13 females, aged 22-87 years, who underwent ultrasound-guided percutaneous drainage. Predisposing factors for the development of psoas abscess, the need for an additional surgical procedure after percutaneous abscess drainage, length of stay in hospital after the procedure, complications, and agent micro-organisms were evaluated. The efficacy of percutaneous drainage in the treatment was investigated.Results: The most common agents were determined to be Staphylococcus aereus, Escherichia coli, and Mycobacterium tuberculosis. Primary psoas abscess was determined in 6 (21.4%) patients and secondary psoas abscess in 22 patients. In cases with secondary psoas abscess, skeletal origin predisposing factors (spondylodiscitis, history of abdominal or vertebral surgery) were seen to most often play a role in the etiology. In 20 of the 22 (78.5%) patients with secondary psoas abscess, effective treatment was applied with antibiotherapy and percutaneous drainage. The mortality rate was 10.7%.Discussion: Low morbidity and mortality rates are the greatest advantages of percutaneous drainage. Although CT has emerged as a better diagnostic method for psoas abscess, ultrasound-guided percutaneous drainage has the advantages of easy availability, low cost, and it does not contain radiation. Ultrasound -guided percutaneous drainage is an effective and reliable method in the treatment of psoas abscess.
Giant Retroperitoneal Liposarcoma with Multi-Organ Involvement
(Derman Medical Publ, 2014) Ugur, Mustafa; Orlic, Cem; Akkucuk, Seckin; Koca, Yavuz Savas; Atci, Nesrin
Retroperitoneal liposarcomas are very rare tumors with poor prognosis. The diagnosis can be delayed since there are no specific symptoms and findings. Surgical resection is the primary treatment choice. Obtaining negative surgical margins should be the primary aim., Multiple organ resections may be essential in cases with huge liposarcoma and incomplete resection leads to local recurrences. There is still an ongoing controversy in the medical treatment of liposarcoma. In this study we presented a patient with liposarcoma who was advised for surgery due to retroperitoneal mass 2 years ago but refused so the mass grew to a huge size invading left kidney, left adrenal gland and left mesocolon. We aimed to point out organ invasion and huge masses of liposarcoma are not contraindications for resection, and resections of these huge tumors improve quality of life. All retroperitoneal masses should be aggressively excised and patients should be closely followed up.
Hemostatic effects of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding model
(Turkish Assoc Trauma Emergency Surgery, 2022) Ozturk, Ozan Utku; Ugur, Mustafa; Guzel, Yelda; Ozturk, Mehmet Ali; Gursoy, Didar; Dogan, Serdar; Temiz, Muhyittin
BACKGROUND: Failure to achieve effective bleeding control and problems related to transfusion in liver surgery are the most common causes of post-operative mortality and morbidity. Various methods/drugs including topical hemostatic agents have been employed for bleeding control in liver surgery. This study was aimed to investigate the hemostatic properties of the herb mixture extract of Inula viscosa and Capsella bursa-pastoris (IvCbp) in rat liver laceration model, which have been traditionally used as antiseptic and hemostatic agents public in Hatay/Tukey. METHODS: Thirty rats were divided into three groups equally and blood samples were taken from all rats for preoperative hemoglobin (Hb) measurements. Then, the standard liver resection model was applied to all rats. Sponge for the first rat group, Ankaferd Blood Stopper (R) Trend-Tech for the second rat group and IvCbp plant extract mixture for the third group were applied to resection areas for 3 minutes. Liver samples of all rats were evaluated in terms of inflammation and necrosis intensity on the 5th post-operative day. RESULTS: operative Hb values were found as 11.0 +/- 1.1 g/dL in the sponge group, 11.9 +/- 2.0 g/dL in the Ankaferd group, and 14.I +/- 1.2 g/dL in the IvCbp herb mixture group (p<0.001). In the histopathological examination, less necrosis was observed in the herb mixture group compared to the sponge and Ankaferd groups (p=0.001). In addition, no statistically significant necrosis difference was observed between sponge and Ankaferd groups. While less inflammation was observed in the herb mixture group compared to the other groups, Ankaferd group had the highest inflammation score (p<0.001). CONCLUSION: IvCbp herb mixture extract group provide effective hemostatic control, caused less Hb decrease and resulted in less inflammation and necrosis compared to Ankaferd and sponge groups in a rat liver resection model.
Left Inguinal Bladder Hernia That Causes Dilatation in the Ureter
(Acad Medical Sciences I R Iran, 2016) Ugur, Mustafa; Atci, Nesrin; Oruc, Cem; Akkucuk, Seckin; Aydogan, Akin
The scrotal bladder hernia is a rare condition that may present a scrotal swelling and urinary system obstruction or in Diagnosis of this condition before the operation decreases the severe complications like bladder, injury during operation. In this article, a 75-year-old man presented to our clinic with right inguinal swelling and lower urinary system infection hernia was diagnosed after performing a computed tomography. The hernia was repaired without any complications.
Left inguinal bladder hernia that causes dilatation in the ureter
(Academy of Medical Sciences of I.R. Iran, 2016) Ugur, Mustafa; Atcı, Nesrin; Oruc, Cem; Akkucuk, Seckin; Aydogan, Akin
The scrotal bladder hernia is a rare condition that may present as scrotal swelling and urinary system obstruction or infection symptoms. Diagnosis of this condition before the operation decreases the severe complications like bladder injury during operation. In this article, a 75-year-old man presented to our clinic with right inguinal swelling and lower urinary system infection. Inguinal bladder hernia was diagnosed after performing a computed tomography. The hernia was repaired without any complications. © 2016, Academy of Medical Sciences of I.R. Iran. All rights reserved.
Mortal quintet of sickle cell diseases
(E-Century Publishing Corp, 2015) Helvaci, Mehmet Rami; Gokce, Cumali; Davran, Ramazan; Akkucuk, Seckin; Ugur, Mustafa; Oruc, Cem
Background: Sickle cell diseases (SCDs) are chronic inflammatory processes on capillary level. We tried to understand some possible correlations between stroke and severity of SCDs. Methods: All patients with SCDs were taken into the study. Results: The study included 343 patients (174 males and 169 females). There were 30 cases (8.7%) with stroke. The mean ages were similar in both groups (32.5 versus 29.1 years in the stroke group and other, respectively, P>0.05). The female ratios were similar in both groups, too (43.3% versus 49.8%, respectively, P>0.05). Prevalences of associated thalassemia minors were also similar in them (73.3% versus 65.1%, respectively, P>0.05). Smoking was higher among the stroke cases, significantly (26.6% versus 13.0%, P<0.05). Mean white blood cell count, hematocrit value, and mean platelet count of the peripheric blood were similar in both groups (P>0.05 for all). On the other hand, although the painful crises per year, tonsilectomy, priapism, ileus, pulmonary hypertension, chronic obstructive pulmonary disease, coronary heart disease, chronic renal disease, rheumatic heart disease, avascular necrosis of bones, cirrhosis, and mortality were all higher in the stroke group, the differences were only significant for acute chest syndrome (ACS), digital clubbing, and leg ulcers (P<0.05 for all), probably due to the small sample size of the stroke group. Conclusion: SCDs and smoking are chronic destructive processes on endothelium, and both terminate with early organ failures in life. Probably smoking, digital clubbing, leg ulcers, ACS, and stroke are mortal quintet of the SCDs that may indicate shortened survival in such patients.
Prognostic value of Prognostic Nutritional Index (PNI) for 5-year recurrence-free survival in surgically resected gastrointestinal stromal tumors
(Edizioni Luigi Pozzi, 2023) Duymus, Mehmet Esat; Ugur, Mustafa; Dal, Mehmet Burak; Aslan, Ersin Rasim; Donmez, Yasemin; Ozgur, Tumay; Secinti, Ilke Evrim
BACKGROUND: Recent studies have investigated the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), and prognostic nutritional index (PNI) on prognosis for various malig-nancies. However, the value of these markers in determining the prognosis for gastrointestinal stromal tumors (GIST) remains controversial. We investigated the effect of NLR, PLR, SII, and PNI on 5-year recurrence-free survival (RFS) in patients with surgically resected GIST. MATERIALS AND METHODS: We retrospectively analyzed patients (n=47) who had undergone surgical resection for pri-mary, localized GIST at a single institution between 2010 and 2021. The patients were divided into two groups accord-ing to the recurrence status in the 5-year period as 5-year RFS(+) (patients with no recurrence (n=25) and 5-year RFS(-) (patients with recurrence (n=22) groups. RESULTS: In univariate analyses, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), tumor localiza-tion, tumor size, PNI, and risk category were significantly different between the RFS(+) and RFS(-) groups while NLR, PLR, SII were not. Multivariate analyses revealed that only the tumor size (HR =5.485, 95% CI: 0.210-143.266, p=0.016), and PNI (HR= 112.020, 95% CI: 8.755-1433.278, p<0.001) were independent prognostic factors for RFS. The patients with a high PNI (>= 46.25) had a higher 5-year RFS rate than the patients with low PNI (<46.25) (95.2% to 19.2%, p<0.001). CONCLUSION: A higher preoperative PNI is an independent positive predictor for 5-year RFS for patients with surgi-cally resected GIST. However, NLR, PLR, and SII have no significant effect.
THE PROTECTIVE EFFECTS OF PEPTIDE YY AND GHRELIN IN ACUTE BILIARY PANCREATITIS
(Carbone Editore, 2014) Aydogan, Akin; Akkucuk, Seckin; Ozkan, Orhan Veli; Aydin, Mehmet; Motor, Sedat; Ugur, Mustafa; Oruc, Cem
Aim: Glzrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-alpha, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited izzflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.
The protective effects of peptide YY and ghrelin in acute biliary pancreatitis
(Acta Medica Mediterranea, 2014) Aydogan, Akin; Akkucuk, Seckin; Ozkan, Orhan Veli; Aydin, Mehmet; Motor, Sedat; Ugur, Mustafa; Oruc, Cem
Aim: Ghrelin and peptide YY are gut hormones that have an anti-inflammatory effect by inhibiting proinflammatory cytokines. We aimed to determine the anti-inflammatory and protective effects of ghrelin and Peptide YY. Methods: The study group included 28 patients with acute biliary pancreatitis and 38 controls. Ghrelin, peptide YY, IL-6, TNF-?, amylase, lipase, glucose, alanine aminotransferase, aspartate aminotransferase, leucocyte count, and hematocrit were measured three times in each patient and once in the control group. Results: Ghrelin levels tended to increase as treatment continued, but still were below the levels in the control group. On the other hand, peptide YY levels in all of the patient samples were higher than in the control group (p>0.001). Conclusion: Ghrelin is proposed as a protective hormone for acute pancreatitis. Exogenous ghrelin exhibits protective activity in caerulein-induced pancreatitis. All previous in vivo and in vitro studies have reported that exogenous PYY administration inhibited inflammation and had protective effects. This study indicates for the first time that endogenous PYY has protective effects on pancreatitis via the inhibition of inflammation, and that these effects are stronger than the effects of ghrelin.
PROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATS
(Carbone Editore, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, Zafer
Aims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein Ilb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60-minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.
Protective effects of tirofiban hydrochloride, a glycoprotein IIb/IIIa inhibitor, on liver ischemia/reperfusion injury in rats
(Acta Medica Mediterranea, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, Zafer
Aims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein IIb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60- minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.
A Rare Cause of Small Bowel Perforation; Tree Branches Ingested: A Case Report
(Derman Medical Publ, 2015) Oruc, Cem; Ugur, Mustafa; Akkucuk, Seckin; Aydogan, Akin
Ingestion of foreign bodies, especially, is more common among children, prisoners, alcoholics, psychiatric patients and the elderly. The majority of ingested foreign bodies pass through the intestinal tract causing perforation less than 1%. Sharp and pointed foreign bodies cause small bowel perforation more frequently than round-tipped objects. In this article, we present a small bowel perforation case of 16 year-old mentally retarded male patient that underwent surgery for the third time for swallowing a number of tree branches who had been undergone two operations previously due to foreign bodies ingestion.

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