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Öğe Acute Mesenteric Ischemia: Clinical Experience(Aves, 2009) Aslan, Ahmet; Temiz, Muhyittin; Semerci, Ersan; Ozkan, Orhan Veli; Yetim, Ibrahim; Fansa, Iyad; Beyaz, FikretBACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requires prompt diagnosis and treatment. The prevention of this cause of high mortality and morbidity depends on early clinical suspicion end timely intervention. In the present study we aimed to analyze the acute mesenteric ischemia cases treated in Mustafa Kemal University Department of General Surgery between January 2004 and December 2008. MATERIAL/METHODS: The clinic records of all the patients who underwent surgical treatment for AMI between January 1, 2004, and December 2008, were retrospectively reviewed. The data from operative records, postoperative complications, mortality, and hospital stay were recorded. RESULTS: The study group included 18 patients. Mean age was 69. There was comorbidity in all patients and cardiac disease and hypertension were the most common ones. The most common laboratory abnormalities were leukocytes, hypoalbuminemia, hyperamylasemia. There was superiorly vascular necrosis in 16 patients; inferior vascular necrosis in one patient. One patient had non occlusive mesenteric ischemia. Segmentery resection was performed to 13 patients. Abdominoperineal resection was performed to the patient with inferior mesenter artery occlusion. We performed duodenotransversostomy on two patients and only laparotomy on two patients. Re-operation was required in 5 patients. Causes of death were multiorgan insufficiency in 7 cases, cardiac death in 2 cases. One patient died due to short intestine syndrome. CONCLUSION: Acute mesenteric ischemia is highly mortal emergency which should always be suspected in elderly patients with cardiac disease suffering from abdominal pain.Öğe The Analysis of Mean Platelet Volume and Platelet Distribution Width Levels in Appendicitis(Springer India, 2015) Aydogan, Akin; Akkucuk, Seckin; Arica, Secil; Motor, Sedat; Karakus, Ali; Ozkan, Orhan Veli; Yetim, IbrahimWe aimed to analyze the diagnostic value of mean platelet volume and platelet distribution width, which are also known as the markers of platelet count, in acute and perforated appendicitis. The data of 202 patients who applied to general surgery clinic in Mustafa Kemal University Hospital from 2007 to 2012 with acute appendicitis were analyzed retrospectively. The findings were separated to two groups due to the perforation status (perforated vs. non-perforated). Age, sex, leukocyte, hemoglobin, hematocrit, mean platelet volume, and platelet distribution width were examined. The mean age of the patients was 35.8. Twenty-one of all cases were perforated appendicitis (10.4 %), and the rest was acute appendicitis (non-perforated) (n=181, 89.6 %). The mean platelet volume value was 9.8 +/- 2.1 fL; mean thrombocyte count, 340.9x10(9)/L; and mean platelet distribution width value, 18.3 %. There were statistically significant differences between sex and age, hemoglobin, hematocrit, leukocyte, mean platelet volume, and platelet distribution width. There was a positive correlation between mean platelet volume, platelet distribution width, and platelet. Age, leukocyte, platelet, mean platelet volume, and platelet distribution width were higher in cases with perforation as a comparison with non-perforated cases. We think that mean platelet volume and platelet distribution width may be valuable markers to detect the risk of perforation in early periods of acute appendicitis.Öğe BILATERAL PRIMARY BREAST LYMPHOMA: A RARE CASE(Aves, 2011) Yetim, Ibrahim; Yetim, Tulin Durgun; Ozkan, Orhan Veli; Diner, Guvenc; Savas, Nazan; Davran, Ramazan; Helvaci, RahmiPrimary non Hodgkin's lymphoma of the breast is rare. Bilateral involvement of the breasts is even morerare. Lymphomas are divided into two groups: Hodgkin's Lymphoma and non Hodgkin's lymphoma. Diffuse large cell non Hodgkin's lymphoma is the most common type. A 56 year old female presented with masses in both breasts. An excisional biopsy was obtained from both tumoral masses. Histopathological assessment revealed diffuse large cell non Hodgkin's lymphoma and chemotherapy was started. Here we present the case of bilateral primary breast lymphoma while discussing clinical characteristics, treatment modalities and the outcomes.Öğe Cholethorax (Bilious Effusion in the Thorax): An Unusual Complication of Laparoscopic Cholecystectomy(Acad Medical Sciences I R Iran, 2013) Aydogan, Akin; Erden, Ersin Sukru; Akkucuk, Seckin; Davran, Ramazan; Yetim, Ibrahim; Ozkan, Orhan VeliCholethorax or bilious effusion in the thorax, is a rare condition in which bile passes into the pleural space from the abdominal cavity, necessitating urgent treatment. In this article, we present a case of cholethorax as a complication of laparoscopic cholecystectomy (LC). The patient underwent a LC due to the presence of a gallbladder polyp. The clip attached to the Hartman opened, and the abdominal cavity became contaminated with binary fluid. Postoperatively, the patient experienced severe right upper quadrant pain and dyspnea. Both the posteroanterior (PA) chest radiography and thoracic computed tomography (CT) were remarkable for marked effusion in the right hemithorax. The patient underwent thoracentesis which resulted in the removal of 250 cc bilious pleural effusion. The bilirubin level of the pleural fluid was 9.1 mg/dL. Following thoracentesis, the patient experienced significant improvement in dyspnea and pain. The patient was discharged without any complications on the seventh day postoperatively. Cholethorax may occur as a result of diaphragmatic injuries secondary to a laparoscopic instrument and can be successfully treated by a thoracentesis.Öğe Comparison of surgical procedures and percutaneous drainage in the treatment of liver hydatide cysts: a retrospective study in an endemic area(E-Century Publishing Corp, 2014) Akkucuk, Seckin; Aydogan, Akin; Ugur, Mustafa; Yetim, Ibrahim; Davran, Ramazan; Oruc, Cem; Kilic, ErolIntroduction: Surgical procedures are still the golden standard option in the treatment of liver cystic echinococcosis. However, minimal invasive technics like percutaneous drainage are rising trends. We aimed to compare the efficacy of surgical and percutaneous options in the treatment of liver hydatidosis in an endemic area. Methods: Patients who underwent surgical or percutaneous procedures for hydatid disease between January 2007 and December 2012 were retrospectively evaluated. Recurrence rates, hospital stay time, and related factors were analyzed. Results: There were 44 (35.5%) male and 80 (64.5%) female patients in this study. Eighty two patients (Group I) had undergone surgery (66.1%) and 42 patients (Group II) had undergone percutaneous drainage (33.9%). The mean cyst size was 7.28 +/- 2.51 cm in Group I and 8.76 +/- 3.30 cm in Group II. Nine recurrences (7.3%) were detected during study. Five of the recurrences were in Group II (11.9%) and four (4.9%) of them were in Group I. The mean length of hospital stay of all patients was 5.42 +/- 3.16 days. Discussion: Percutaneous drainage techniques can be a good alternative to surgery in selected patients. In complicated cases like cystobiliary fistula, surgery is superior to percutaneous approaches. The hospital stay time, recurrence rate and postoperative complications were not enhanced when compared to percutaneous treatment in our study. Despite all controversy about the low morbidity after percutaneous treatment, surgical approach is still a preferable option in patients with liver hydatidosis when it is performed by experienced surgeons.Öğe Delayed diagnosis of traumatic diaphragmatic hernia may cause colonic perforation: A case report(2009) Ozkan, Orhan Veli; Semerci, Ersan; Yetim, Ibrahim; Davran, Ramazan; Diner, Guvenc; Paltaci, IlhanEarly diagnosis of diaphragmatic rupture after traumas may be difficult, and delayed diagnosis may result in increased morbidity and mortality. This paper describes the case of a 32-year-old man who experienced a traffic accident and had diagnosis of traumatic diaphragmatic hernia nearly four months later. The patient was referred to our emergency room suffering from ileus symptoms. Physical examination demonstrated an apparent abdominal distention, tenderness at the upper abdominal quadrants, rebound, and defense. Thoraco-abdominal X-rays and computerized tomography imaging demonstrated intestinal segments with air-fluid levels in thorax. Laparotomy was performed after a preoperative diagnosis of a strangulated-diaphragmatic hernia. At abdominal exploration, it was found that transverse colon and omentum entered into thorax through diaphragmatic defect located at the left diaphragm. Herniating colon segment was complicated with ischemic necrosis and perforation. In conclusion, colon necrosis and perforation may develop when early diagnosis of diaphragmatic ruptures are missed. © 2009 Ozkan et al.; licensee Cases Network Ltd.Öğe Effects of ?-Glucan Pretreatment on Acetylsalicylic Acid-Induced Gastric Damage: An Experimental Study in Rats(Elsevier Science Inc, 2010) Ozkan, Orhan Veli; Ozturk, Oktay Hasan; Aydin, Mehmet; Yilmaz, Nigar; Yetim, Ibrahim; Nacar, Ahmet; Oktar, SuleymanBACKGROUND: NSAIDs have been found to induce gastrointestinal tract damage. Recently, it has been suggested that this might be mediated by lipid peroxidation. OBJECTIVE: The aim of this study was to assess the potential protective effects of beta-glucan against acetylsalicylic acid (ASA)-induced gastric damage by means of its antioxidant capacity in an experimental rat model. METHODS: Thirty-two male Wistar albino rats (200-250 g) were randomized into 4 groups consisting of 8 rats each. The beta-glucan group received 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. The ASA group received saline once a day for 10 days and 300 mg/kg (20 mg/mL) ASA as a single dose, 4 hours before anesthesia. The ASA+beta-glucan group was administered 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. Additionally, 300 mg/kg (20 mg/mL) ASA was administered as a single dose, 4 hours before anesthesia. The control group received saline once a day for 10 days and 30 minutes before anesthesia. All medications were administered by intragastric gavage. The stomach from each rat was dissected and divided into 2 parts for histologic and biochemical analysis. Gastric tissue malondialdehyde (MDA), nitric oxide (NO) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were determined for oxidative parameter analysis. RESULTS: The gastroprotective and antioxidant effects of beta-glucan appeared to attenuate the ASA-induced gastric tissue damage. Compared with the control group, MDA and NO levels and CAT and GSH-Px activities were significantly increased in the stomachs of ASA-treated rats (MDA, 4.12 [0.44] to 13.41 [1.05] mu mol/L; NO, 8.04 [7.25-9.10] vs 30.35 [22.34-37.95] mu mol/g protein; CAT, 0.050 [0.004] to 0.083 [0.003] k/g protein; GSH-Px, 0.57 [0.42-0.66] to 1.55 [1.19-1.76] U/L; all, P < 0.001), whereas SOD activity was significantly decreased in the same group (291 [29] to 124 [61 U/mL; P < 0.001). In the ASA+beta-glucan group, MDA and NO levels and CAT and GSH-Px activities were found to be significantly lower, while SOD activity was found to be significantly higher, in comparison with the ASA-treated group (all, P < 0.001). CONCLUSION: beta-Glucan appeared to attenuate the gastric damage caused by ASA in these rats. (Curr Ther Res Clin Exp. 2010;71:369-383) (C) 2010 Elsevier HS Journals, Inc.Öğe Esophagitis Corrosive Treatment of N-acetyl Cysteine Preventing Early Stricture use development activity(Aves, 2011) Yetim, Tulin Durgun; Yetim, Ibrahim; Duru, MehmetObjective: Esophageal stricture early corrosive burns to investigate the effectiveness in preventing the use of N-acetyl-cysteine. Strictures of the esophagus due to caustic substances occur with the ingestion of solid or liquid corrosive materials. Materials and Methods: A prospective randomized study was performed to evaluate the effectiveness of conventional therapy alone and conventional therapy + N-acetyl cysteine. Fifty patients with grade 2b and grade 3 burnt were analyzed. Intensive n-acetyl cysteine therapy can reduce the incidence of stricture development in patients with advanced grade corrosive esophagitis. Results: N-acetyl cysteine group+ Konvansitonel used in 1 patient, stenosis developed in 7 patients in the group with conventional treatment. Conclusion: We believe that our findings will be better supported with the groups including larger number of patients or with the experimental studies.Öğe Gossypiboma Causing Mechanical Intestinal Obstruction: A Case Report(Hindawi Ltd, 2012) Aydogan, Akin; Akkucuk, Seckin; Yetim, Ibrahim; Ozkan, Orhan Veli; Karcioglu, MuratIntroduction. Gossypiboma (GP) is a term used to express the mass resulting from forgotten cotton sponge in operations. Rarely, a transmural migration may occur into the gastrointestinal lumen without creating any defect by GP. Laparotomy or endoscopic removal may be required, by the way it can be taken out of the body itself by intestinal ways. In this study, we reported a case of mechanical intestinal obstruction causing GP. Case. The fifty-one-year-old female patient admitted to the emergency department with the complaints of mechanical intestinal obstruction and had a history of open cholecystectomy 20 years ago. There were the findings of intestinal obstruction in abdominal plain radiography and computerized tomography. The sponge that obstructed the lumen completely 40 cm proximal to the ileocecal valve was identified in the laparotomy with the diagnosis of brid ileus. The small intestine was closed over double-fold after removal of sponge. Transmural migration of abdominal-remained sponge was thought to be occurred without creating a defect after cholecystectomy. Postoperatively, the patient was discharged without having any problems at 4th day of hospitalization. Conclusion. Although it is a rare situation in routine clinical practice, GP should be considered as a differential diagnosis in the patients who had a diagnosis of mechanical intestinal obstruction, and laparotomy was applied before. As GP may lead to situations which cause mortality, all precautions should be taken to prevent it.Öğe Investigation of the effect of intercostal blockade in palliation of pain in patients with rib fracture(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2012) Yetim, Tulin Durgun; Yetim, Ibrahim; Duru, MehmetBackground: This study aims to investigate the effect of intercostal nerve blockade on pain in patients with rib fracture and its effect in reducing the opioid use requirement. Methods: Between August 2008 and July 2010, 120 patients with rib fractures in Antakya State Hospital and Mustafa Kemal University, Faculty of Medicine were included in this clinical randomized prospective study. Patients were divided into two groups. Group 1 (n=60) received tramadol (200 mg/day) and lornoxicam (8 mg/day). In group 2 (n=60), intercostal nerve blockade (0.5% bupivakain 3 ml) was performed in addition to tramadol (50 mg/day) and lornoxicam (8 mg/day) treatment. Scores of patient satisfaction visual analogue scale (VAS) were recorded both at rest and during coughing. At the end of 24 hours, total amount of tramadol used and the number of analgesic demands were recorded. Results: No statistically significant difference in VAS scores between the two groups was observed (p<0.05). However, the amount of tramadol used and the number of analgesic demand were significantly lower in the intercostal nerve blockade group (p<0.05). Conclusion: We concluded that intercostal blockade in the pain management in patients with rib fractures was effective in decreasing the dosage of opioid and thus reducing side effects which might occur.Öğe Laparoscopic Cholecystectomy Results In Patients With Different Age Groups(Derman Medical Publ, 2011) Yetim, Ibrahim; Dervisoglu, Adem; Karakose, Oktay; Buyukkarabacak, Yalcin; Bek, Yuksel; Erzurumlu, KenanAim Laparoscopic cholecystectomy (LC) has been most preferable method for benign gallbladder disease. Advanced age may be increased morbidity and mortality. The aim of this study was to compare the results of LC in patients according to different ages (age <= 30, 31 -64 years, and age >= 65). Material and Methods A retrospective analysis was performed including overall 511 patients who underwent LC for benign disease of gallbladder at Ondokuzmayis University Medical Faculty and Mustafa Kemal University, Medical Faculty between November 2001 and November 2009. The patients are divided into three groups according to ages: Group A (age <= 30 years, n = 47), Group B (age = 31 -64 years, n = 368), Group C (age >= 65, n = 96). Results Symptomatic cholelithiasis was the most common indication for LC in all the groups (p > 0.05). Co-morbid diseases were significantly higher in the Group C (>= 65 years) than in the Group A and B (<= 30 years, 31 -64 years) (p= 0.001). Co-incidental biliary pathologies, and history of abdominal operation were similar in all the groups. However biliary duct and cystic artery anomalies were significantly more common in the Group A than in the Group B and C (p= 0.001). Conversion to OC was required in 26 (5.08 %) patients in this study. The major reason for the (21 cases, 80.76 %) was difficult dissection of the Calot's triangle. There was no difference in morbidity among the groups (p> 0.05). Conclusions As a conclusion, it's thought that biliary anomalies in young patients and co-morbid diseases disorders in elderly patients are more common. These factors do not affect the results of patient that preoperatively well evaluated. However surgeon should be aware of this condition and be careful for intraoperative and postoperative complication.Öğe Necrotizing pancreatitis with hypertriglyceridemia development result: A cese port(Derman Medical Publ, 2011) Yetim, Ibrahim; Ozkan, Orhan Veli; Diner, Guvenc; Yilmaz, Aydin; Gokce, Cumali; Kaya, HasanAcute pancreatitis due to hypertriglyceridemia is a relatively rare clinical entity. Acute pancreatic necrosis is a life threatening form of acute pancreatitis in which early recognition and treatment is important. Necrotising pancreatitis should be treated immediately. We presented a case of pancreatic necrosis due to hypert-riglyceridemia which required surgical intervention. We performed necro-sectomy. After surgery the patient recovered. We presented the case in order to mention necrotising pancreatitis arising from hypertriglyceridemia and requiring surgical exploration.Öğe Our Experience with Esophageal Foreign Bodies(Aves, 2012) Yetim, Tlin Durgun; Yetim, Ibrahim; Bayarogullari, Hanifi; Davarci, IsilObjective: Foreign bodies in the esophagus can lead to fatal complications if diagnosis and treatment are delayed. The importance of early diagnosis and treatment methods were evaluated in this retrospective study on cases admitted to our clinics with a diagnosis of esophageal foreign body. Material and Methods: Fifty-two patients who had been admitted to Antakya State Hospital and the Department of Thoracic Surgery at Mustafa Kemal University with a diagnosis of esophageal foreign body between August 2008 and June 2011 were evaluated retrospectively for age, gender, type of foreign body, time interval to admission, location of the foreign body, treatment method, symptoms and complications. Results: Twenty-eight of the patients were female (54%) and 24 were male (46%). The youngest patient was 12 months old and the oldest was 80 years old. Thirty-four patients (65%) were aged 60 and over. In this age group, 50% of the removed foreign bodies were bone. Hypersalivation was the most common symptom among patients (58%), followed by dysphasia (20%), a stinging sensation (15%) and dyspnea (7%). No patients developed complications after the removal of the foreign body. Conclusion: Esophageal foreign bodies are significant due to the life-threatening complications they may cause. Thus, early diagnosis and treatment are crucial. Rigid esophagoscopy is still the most reliable method of treatment.Öğe Our Tyroid Surgery Clinic Experience(Derman Medical Publ, 2011) Yetim, Ibrahim; Kardes, Kenan; Karaca, Selami; Sacin, AdnanAim Surgical treatment of thyroid gland diseases is performed by many centers. In this study, we obtained from patients who underwent thyroid surgery results were compared with literature data. Material and Methods Between April 2005-March 2008 Nafiz Kurt Bafra Samsun State Hospital, General Surgery, thyroidectomy, and complication rates were analyzed retrospectively 146 patients were identified. Results Mortality, wound infection, recurrence, and permanent recurrent laryngeal nerve injury was observed. Temporary laryngeal nerve injury in eight patients, three patients hipoparatroidi temporary, one permanent hipoparatroidi patients, 20 patients with hypothyroidism and the hematoma was observed in six patients. Among these patients, 126 patients with benign and malignant thyroid masses were detected in 20 patients. 110 patients with benign nodular colloidal goiter, in 18 cases of adenoma, thyroiditis in 14 cases, four cases were detected in the diffuse colloidal goiter. In 12 patients with malignant patients and eight patients with papillary carcinoma and follicular carcinoma showed trioid. Conclusions Our results compared with the studies currently being implemented and highly reliable technique troidektominin were found to be adequate.Öğe Praziquantel-Dymethylsuifoxide Solution: The Side Effect on Hepato-biliary System (An Experimental Study)(Derman Medical Publ, 2010) Yetim, Ibrahim; Buyukkarabacak, Yalcin; Erzurumlu, Kenan; Dervisoglu, Adem; Hokelek, Murat; Baris, Sancar; Bek, YukselAim In this experimental study, the side effects of praziquantel and dymethylsulfoxide on the hepatobiliary system has been investigated comparing with alcohol, hypertonic and normal saline. Material and Methods This study contains five groups of ten rats each. In all groups, transduodenal choledochal cannulation was done and either dymethylsulfoxide, praziquantel in dymethylsulfoxide solution,0.9 % NaCI, 20 % NaCI or 98 % alcohol were injected. Before surgery, blood samples were taken for measuring AST, ALT, ALP, GGT levels, and repeated every months for three months period. At the end of study, all rats were sacrificed; hepatobiliary excision was done. Results Biochemical content and blood samples have not statistically significant difference at the beginning of the study. After protoscolocidals injection into common bile duct, ALT, AST and ALP levels were siginificantly found higher at hypertonic saline group than control's (p<0.05). GGT level in hypertonic saline group was similar to control's. Also allthe biochemical results were siginificantly higher at dymethylsulfoxide, praziquantel in dymethylsulfoxide solution and alcohol groups than hypertonic saline and control groups (p<0.05). Although ALT, AST and ALP levels were found highest in hypertonic saline group; GGT level were was highest in dymethylsulfoxide group, (p<0.05) (Figure 1, 2, 3, 4). Histopathological research has shown that hepatoceluler changes were siginificantly higher in hypertonic saline group than control group, (p<0.05) Also it was higher in alcohol, dymethylsulfoxide and praziquantel in dymethylsulfoxide solution groups than the others, (p<0.05) Although dymethylsulfoxide and hypertonic saline have similar side effects on biliary tract; praziquantel in dymethylsulfoxide solution solution has stronger side effect then them, (p<0.05) alcohol has strongest side effect on biliary tract, (p<0.05). Conclusions As a conclusion, it is thought that praziquantel in dymethylsulfoxide solution solution has similar risk to alcohol and more than hypertonic saline on hepatobiliary tract in intraoperative use for hepatic hydatidosis.Öğe Protective effects of tirofiban hydrochloride, a glycoprotein IIb/IIIa inhibitor, on liver ischemia/reperfusion injury in rats(Acta Medica Mediterranea, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, ZaferAims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein IIb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60- minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.Öğe PROTECTIVE EFFECTS OF TIROFIBAN HYDROCHLORIDE, A GLYCOPROTEIN IIB/IIIA INHIBITOR, ON LIVER ISCHEMIA/REPERFUSION INJURY IN RATS(Carbone Editore, 2015) Paltaci, Ilhan; Aydogan, Akin; Akkucuk, Seckin; Temiz, Muhyittin; Yetim, Ibrahim; Ugur, Mustafa; Yonden, ZaferAims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein Ilb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: We induced a 45-minute hepatic ischemia via portal vein, hepatic artery and bile ducts and a 60-minute reperfusion immediately after hepatic ischemia in male albino Wistar rats. One of the groups received intraperitoneal 0.25 mg/ml TH 30 minutes before ischemia and other received intraperitoneal 0.25 mg/ml TH 30 minutes before reperfusion. At the end of the experiment, all animals were decapitated and blood and tissue samples were collected. Results: To evaluate hepatic functions, we assessed serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). In hepatic tissue samples, catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels were evaluated. We stained hepatic tissue samples with Hematoxylin and Eosin and explored them with a light microscope. Serum AST, ALT, and LDH levels were increased after IR and decreased significantly in the group in which TH was administered. Tissue CAT, SOD, and GSH levels were decreased in IR groups. In TH groups, antioxidant levels were increased when compared to IR groups. Hepatocellular injury that indicates IR-related damage was decreased substantially after TH administration. Conclusion: According to the results of the study, TH decreased the destructive effects of IR. We suggest that TH treatment may can be used in the treatment of hepatic IR damage.Öğe Rare cause of intestinal obstruction, Ascaris lumbricoides infestation: Two case reports(2009) Yetim, Ibrahim; Ozkan, Orhan Veli; Semerci, Ersan; Abanoz, RecepAscaris lumbricoides is common resident of intestine especially low socioeconomic areas in the world. Complication of Ascaris lumbricoides has been reported include obstruction of the small intestine, intestinal volvulus and intussusception. We report two children with severe sequelae of intestinal obstruction. © 2009 Yetim et al; licensee Cases Network Ltd.Öğe Safety and efficacy of tirofiban hydrochloride (TH) in cerulein-induced acute pancreatitis(A. CARBONE Editore, 2015) Kaplan, Aydin; Akkucuk, Seckin; Ugur, Mustafa; Aydogan, Akin; Ozgur, Tumay; Caliskan, Yasemin; Yetim, IbrahimIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute pancreatitis.Öğe SAFETY AND EFFICACY OF TIROFIBAN HYDROCHLORIDE (TH) IN CERULEIN-INDUCED ACUTE PANCREATITIS(Carbone Editore, 2015) Kaplan, Aydin; Akkucuk, Seckin; Ugur, Mustafa; Aydogan, Akin; Ozgur, Tumay; Caliskan, Yasemin; Yetim, IbrahimIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute. pancreatitis.
