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  • Küçük Resim
    Öğe
    Contractile Effects of Eryngium kotschyi Boiss. on Rat Isolated Ileum and Detrussor Muscle
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2014) Baydan, Emine; Kartal, Murat; Yurdakok, Begum; Erdem, Sinem Aslan; Ince, Sinan; Ekici, Husamettin; Alp, Harun
    The pharmacological activity of the aerial (EKA) and root (EKR) parts of the endemic plant, Eryngium kotschyi Boiss., on rat isolated ileum and detrusor muscle was investigated. Plant extracts alone and with the presence of agonist (acethylcholine) and antagonist (atropin, verapamile, oxybutinine-detrusor muscle, and papaverine-ileum) drugs, along with Ca2+ applications on calcium-free medium, were applied. Plant extracts induced contraction in ileum and detrusor muscle where the contractions were concentration dependant for EKA and EKR single dose applications in detrusor muscle and concentration-free contractions were observed in cumulative applications for both tissues. Aerial and root parts of Eryngium extracts induced contractions in dose, tissue and protocol dependent manner where the contractions were affected by the tested antagonists, which could be attributed to non-specific pathways including calcium ions and calcium channel stimulations.
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    Öğe
    Subacute toxicity of piperonyl butoxide and resmethrin in mice
    (Academic Journals, 2012) Urek, Selma Yazar; Baydan, Emine; Yurdakok, Begum; Akaydin, Yesim; Kozlu, Tolunay; Tunca, Ayse
    The subacute toxic effects of separate and combined use of piperonyl butoxide and resmethrin (cismethrin) on the liver and kidneys of male mice were investigated. It is known that when given alone, pyrethroids are toxic and their toxicity becomes more complicated when they are co-formulated with piperonyl butoxide. In the present study, macroscopic and microscopic changes were determined in the liver and kidney tissues. Furthermore, biochemical alterations and clinical neurotoxic effects were observed. Toxic effects were more evident in the group subjected to combined use. The results obtained demonstrated that, in mice, piperonyl butoxide and resmethrin are directly toxic to the liver and kidneys. The toxic effects and tissue degeneration were more widespread in the group subjected to combined use.