The relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genes

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dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorKutlu, Tuncer
dc.date.accessioned2024-09-18T20:13:29Z
dc.date.available2024-09-18T20:13:29Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe use of fructose as converted sugar in the food industry is quite common. Steatosis and degeneration occur due to the use of fructose in the liver where sugar is primarily metabolized. However, there is not enough information about the level of MDA and the expression levels of COX-2 and NRF-2 in the liver with low and high fructose consumption. The aim of the study is to evaluate the effect of different concentrations of fructose solutions on the expression levels of COX-2 and NRF-2 genes as well as MDA levels in the livers of rats. In this study, the effects of different fructose solution [F15; (15%) F30; (30%) and F60; (60%)] consumption for 10 weeks in rats on the MDA levels also COX-2 and NRF-2 genes expression levels in the liver were investigated. The MDA level and COX-2 gene expression level in F60 group were higher than the control and other groups (P<0.01). These findings suggest that MDA elevation in the liver may be due to inflammation. However, no change was observed in total NRF -2 gene expression. Also, a positive correlation was found between levels of COX-2 and NRF-2 expressions in F30 (0.965; P<0.01). These findings may be attributed to inflammation of liver. This may have been due to an increase in nuclear formation of NRF-2. As a result, the use of high concentration fructose solution has been found to increase the level of MDA in the liver due to inflammation.en_US
dc.description.sponsorshipTUBITAK [118O381]en_US
dc.description.sponsorshipThis study was financially supported by TUBITAK (118O381).en_US
dc.identifier.doi10.33988/auvfd.645713
dc.identifier.endpage392en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85090532433en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage387en_US
dc.identifier.trdizinid1109828en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.645713
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1109828
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9220
dc.identifier.volume67en_US
dc.identifier.wosWOS:000564411900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOX-2en_US
dc.subjectfructoseen_US
dc.subjectgene expressionen_US
dc.subjectMDAen_US
dc.subjectNRF-2en_US
dc.titleThe relationship of fructose consumption with MDA levels in rat liver and its effect on the expression levels of COX-2 and NRF-2 genesen_US
dc.typeArticleen_US

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