Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model

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dc.authoridPOLAT, ELIF/0000-0001-6808-5467
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.authoridKAYA, SERKAN/0000-0002-9817-744X
dc.contributor.authorKaya, Serkan
dc.contributor.authorKaya, Sinem Albayrak
dc.contributor.authorPolat, Elif
dc.contributor.authorErboga, Zeynep Fidanol
dc.contributor.authorDuran, Yasin
dc.contributor.authorPolat, Fatin Rustu
dc.contributor.authorOkuyan, Hamza Malik
dc.date.accessioned2024-09-18T19:50:20Z
dc.date.available2024-09-18T19:50:20Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: In this experimental study, we aimed to investigate the effects of hesperetin. a natural flavonoid, on a lipopolysaccharide-induced acute lung injury model in rats. Methods: Between March 2019 and May 2019, a total of 18 adult male Wistar albino rats, weighing approximately 250 to 300 g, were randomly divided into three groups as control, lipopolysaccharide, and lipopolysaccharide + hesperetin groups (n=6 in each group). The wetidry weight ratio of lung tissue was determined. Histopathological changes were examined using light and scanning electron microscopy. Pulmonary nuclear factor-kappa beta, inducible nitric oxide synthase, and alpha-smooth muscle antigen activity were determined with indirect immunohistochemical methods. Pulmonary apoptosis was detected with the terminal deoxynucleotidyl transferase dUTP nick-end labeling method. Tumor necrosis factor-alpha. interleukin-1 beta, interleukin-6, and interleukin-10 concentrations were measured with enzyme-linked immunosorbent assay. Results: Treatment with hesperetin significantly improved the architecture of lung tissue and reduced the wet/dry weight ratio, nuclear factor-kappa beta, inducible nitric oxide synthase, and alphasmooth muscle antigen expression, pulmonary apoptosis, and levels of proinflammatory cytokines. Conclusion: Our study results suggest that hesperetin has a potent protective effect against lipopolysaccharide-induced acute lung injury in rats via suppression of the proinflammatory cytokine cascade, nuclear factor-kappa beta. signaling pathway activation, and apoptosis.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2020.18816
dc.identifier.endpage368en_US
dc.identifier.issn1301-5680
dc.identifier.issue2en_US
dc.identifier.pmid32551168en_US
dc.identifier.scopus2-s2.0-85085133382en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage359en_US
dc.identifier.trdizinid371531en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2020.18816
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/371531
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7368
dc.identifier.volume28en_US
dc.identifier.wosWOS:000529820900020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute lung injuryen_US
dc.subjectinducible nitric oxide synihaseen_US
dc.subjectlipopolysaccharideen_US
dc.subjectnuclear factor-kappa betaen_US
dc.subjectpulmonary apoptosisen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleProtective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat modelen_US
dc.typeArticleen_US

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