Deneysel hiperkalemi oluşturulan tavşanlarda norepinefrinin kalp fonksiyonları üzerine etkileri
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Dosyalar
Tarih
2003
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info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, yaşlan 10-14 ay arasında değişen ve ortalama ağırlıkları 2-3 kg olan 11 dişi ve l erkek toplam 12 Yeni Zelanda tavşanı kullanıldı. Bu hayvanlar "pozitif kontrol" (n: 6) ve "norepinefrin grubu" (n: 6) olmak üzere iki gruba ayrıldı. Nor-epinefrin ve pozitif kontrol grubu tavşanlara, 300 m M konsantrasyondaki KC1 çözeltisi (izotonik NaCl içerisinde) 0.5 ml/kg/dk hızda 15 dk süre ile v. auricularis'den verilerek hiperkalemi oluşturuldu. Norepinefrin grubu hayvanlara 15. dk'dan sonra 1.3 $mu$g/kg/dk dozunda 30 dk süre ile norepinefrin infüzyon şeklinde verildi. Her iki gruba ait tüm tavşanlardan O, 15, 30, 60 ve 90. dk'larda serum potasyum düzeyini saptamak için kan alındı ve ilk 45 dk'lık sürede her 3 dk'da, 45. dk'dan sonra ise sadece 60. ve 90. dk'larda EKG çekimleri yapıldı. Deneysel oluşturulan hiperkalemili hayvanlardan pozitif kontrol grubunda serum potasyum düzeyi 30. dk'da pik noktaya ulaştı, daha sonra düşüşe geçti. Buna karşın, norepinefrin grubunda potasyum seviyesi pik noktaya ulaşmadan düşmeye başladı. Buna paralel olarak, hiperkaleminin tipik belirtileri olan bradikardi, EKG'deki P dalgasının düzleşmesi ve QRS kompleksindeki genişlemenin norepinefrin uygulaması ile deney öncesi değerlerine yaklaştığı saptandı. Sonuç olarak, kardiyotoksik etkisi ile kliniklerde acil müdahale gerektiren hiperkaleminin sağaltımında, norepinefrinin diğer tedavilerle birlikte uygulanabileceği kanısına varıldı.
In this study, 10 to 14 month-olds 12 (11 female and 1 male) New Zealand rabbits weighing 2-3 kg were used. These animals were divided into two groups as "positive control" (n: 6) and "norepinephrine group" (n: 6). The animals in both groups were made hyperkalemic by administering 300 mM KC1 solution (prepared in 0.9% NaCl solution) via v. auricularis at 0.5 ml/kg/mi n for 15 minute. Norepinephrine was administered at 1.3 $mu$.g/kg/minute to the animals in the norepinephrine group after the 15Ul minute for 30 minutes. In order to measure serum potassium level, blood samples were collected from the animals of both groups, and for the first 45 minutes every 3 minutes and at 60 and 90th minutes, ECG recordings were taken. In the animals with hyperkalemia in the positive control group, the level of serum potassium peaked at 30th minute and then started to decrease; on the contrary, application of norepinephrine in the other group caused the level of potassium to decrease after 15th minute without reaching to the peak. It was determined that the typical signs of hyperkalemia including bradycardia, flattened P wave and widened QRS complex in ECG were corrected by the application of norepinephrine. In conclusion, in the treatment of hyperkalemia requiring urgent interventions due to cardiotoxic effects, norepinephrine may be used together with other therapeutic approaches to correct the serum potassium level.
In this study, 10 to 14 month-olds 12 (11 female and 1 male) New Zealand rabbits weighing 2-3 kg were used. These animals were divided into two groups as "positive control" (n: 6) and "norepinephrine group" (n: 6). The animals in both groups were made hyperkalemic by administering 300 mM KC1 solution (prepared in 0.9% NaCl solution) via v. auricularis at 0.5 ml/kg/mi n for 15 minute. Norepinephrine was administered at 1.3 $mu$.g/kg/minute to the animals in the norepinephrine group after the 15Ul minute for 30 minutes. In order to measure serum potassium level, blood samples were collected from the animals of both groups, and for the first 45 minutes every 3 minutes and at 60 and 90th minutes, ECG recordings were taken. In the animals with hyperkalemia in the positive control group, the level of serum potassium peaked at 30th minute and then started to decrease; on the contrary, application of norepinephrine in the other group caused the level of potassium to decrease after 15th minute without reaching to the peak. It was determined that the typical signs of hyperkalemia including bradycardia, flattened P wave and widened QRS complex in ECG were corrected by the application of norepinephrine. In conclusion, in the treatment of hyperkalemia requiring urgent interventions due to cardiotoxic effects, norepinephrine may be used together with other therapeutic approaches to correct the serum potassium level.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Ankara Üniversitesi Veteriner Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
50
Sayı
1
