Accelerated atherosclerosis and digital clubbing in sickle cell diseases
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medi+World Int
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sickle cell diseases (SCDs) are chronic destructive processes mainly on the capillary endothelium. We tried to understand the significance of digital clubbing in severity of SCDs. Methods: All patients with SCDs were taken into the study. Results: The study included 397 patients (193 females). There were 36 cases (9.0%) with digital clubbing. Male ratio was significantly higher in the digital clubbing group (66.6% versus 49.8%, p<0.05). The mean age was significantly higher in the digital clubbing group, too (36.5 versus 29.0 years, p=0.000). Additionally, smoking was also higher in the digital clubbing group, significantly (30.5% versus 11.0%, p<0.001). The mean white blood cell counts of peripheric blood were similar in both groups (p<0.05). On the other hand, the mean hematocrit value and platelet count of peripheric blood were lower in the digital clubbing group, significantly (p=0.001 and p=0.012, respectively). Beside that, prevalence of leg ulcers, pulmonary hypertension, chronic obstructive pulmonary disease, coronary heart disease, cirrhosis, and stroke were significantly higher in the digital clubbing group (p<0.01 for all). There were 25 mortalities during the period, and 13 of them were males. The mean ages of mortality were 33.0 +/- 9.6 (range 1947) in females and 30.0 +/- 8.6 years (range 19-50) in males. Conclusion: SCDs are chronic destructive processes on endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Probably digital clubbing is one of the terminal consequences of the SCDs indicating significantly shortened survival in such patients.
Açıklama
Anahtar Kelimeler
Sickle cell diseases, digital clubbing, chronic capillary damage, accelerated atherosclerosis, metabolic syndrome
Kaynak
World Family Medicine
WoS Q DeÄŸeri
N/A
Scopus Q DeÄŸeri
Cilt
14
Sayı
3
