Accelerated atherosclerosis and digital clubbing in sickle cell diseases

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dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorSahan, Mustafa
dc.contributor.authorSulhan, Agit
dc.contributor.authorAcik, Abdullah Fatih
dc.contributor.authorOcak, Adil
dc.contributor.authorSalaz, Semih
dc.contributor.authorPocock, Lesley
dc.date.accessioned2024-09-18T20:57:02Z
dc.date.available2024-09-18T20:57:02Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractBackground: Sickle cell diseases (SCDs) are chronic destructive processes mainly on the capillary endothelium. We tried to understand the significance of digital clubbing in severity of SCDs. Methods: All patients with SCDs were taken into the study. Results: The study included 397 patients (193 females). There were 36 cases (9.0%) with digital clubbing. Male ratio was significantly higher in the digital clubbing group (66.6% versus 49.8%, p<0.05). The mean age was significantly higher in the digital clubbing group, too (36.5 versus 29.0 years, p=0.000). Additionally, smoking was also higher in the digital clubbing group, significantly (30.5% versus 11.0%, p<0.001). The mean white blood cell counts of peripheric blood were similar in both groups (p<0.05). On the other hand, the mean hematocrit value and platelet count of peripheric blood were lower in the digital clubbing group, significantly (p=0.001 and p=0.012, respectively). Beside that, prevalence of leg ulcers, pulmonary hypertension, chronic obstructive pulmonary disease, coronary heart disease, cirrhosis, and stroke were significantly higher in the digital clubbing group (p<0.01 for all). There were 25 mortalities during the period, and 13 of them were males. The mean ages of mortality were 33.0 +/- 9.6 (range 1947) in females and 30.0 +/- 8.6 years (range 19-50) in males. Conclusion: SCDs are chronic destructive processes on endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Probably digital clubbing is one of the terminal consequences of the SCDs indicating significantly shortened survival in such patients.en_US
dc.identifier.doi10.5742/MEWFM.2015.92797
dc.identifier.endpage16en_US
dc.identifier.issn1839-0188
dc.identifier.issn1839-0196
dc.identifier.issue3en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.5742/MEWFM.2015.92797
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12251
dc.identifier.volume14en_US
dc.identifier.wosWOS:000385846400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedi+World Inten_US
dc.relation.ispartofWorld Family Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell diseasesen_US
dc.subjectdigital clubbingen_US
dc.subjectchronic capillary damageen_US
dc.subjectaccelerated atherosclerosisen_US
dc.subjectmetabolic syndromeen_US
dc.titleAccelerated atherosclerosis and digital clubbing in sickle cell diseasesen_US
dc.typeArticleen_US

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