The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats
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Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: The aim of this experimental study was to compare the dose-related effect of topical thymoquinone (TO) with other topical agents used in the management of acute otitis externa (AOE) in a rat model. MATERIALS and METHODS: Forty-eight male Wistar albino rats were divided into six groups each with eight rats per group. Group I was the control group with no external otitis, whereas external otitis wee created in the other five groups (study groups). Dexamethasone, 0.1%TQ, 0.4% TQ, ciprofloxacin, and 0.9% saline (NaCl) drops was applied once daily in Groups II-VI, respectively. The treatment was administered regularly for 10 days. Pathologic and microbiologic evaluation were performed. Pathologically, the thicknesses of the stroma and the epithelium in the external auditory canal (EAC) were measured using an occulometer. Edema in the stroma, density of inflammatory cells and blood vessels, presence of fibroblasts, and changes in collagen fibers in the EAC were evaluated in five different areas to obtain the area of highest concentration and classified into four grades (0=no change, 1=mild, 2=moderate, 3=severe). RESULTS:The higher concentration of TO (0.4%) was more effective than dexamethasone and 0.1% TO with respect to antibacterial and the anti-inflammatory properties. CONCLUSION: TO, particularly at a concentration of 0.4%, may be considered for topical application alone in the treatment of AOE, without any requirement for a combined treatment.
Açıklama
Anahtar Kelimeler
Thymoquinone, acute otitis externa, treatment, experimental study
Kaynak
Journal of International Advanced Otology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
14
Sayı
2
