The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorDemirel, Hasan
dc.contributor.authorArli, Cengiz
dc.contributor.authorOzgur, Tumay
dc.contributor.authorInci, Melek
dc.contributor.authorDokuyucu, Recep
dc.date.accessioned2024-09-18T20:59:26Z
dc.date.available2024-09-18T20:59:26Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this experimental study was to compare the dose-related effect of topical thymoquinone (TO) with other topical agents used in the management of acute otitis externa (AOE) in a rat model. MATERIALS and METHODS: Forty-eight male Wistar albino rats were divided into six groups each with eight rats per group. Group I was the control group with no external otitis, whereas external otitis wee created in the other five groups (study groups). Dexamethasone, 0.1%TQ, 0.4% TQ, ciprofloxacin, and 0.9% saline (NaCl) drops was applied once daily in Groups II-VI, respectively. The treatment was administered regularly for 10 days. Pathologic and microbiologic evaluation were performed. Pathologically, the thicknesses of the stroma and the epithelium in the external auditory canal (EAC) were measured using an occulometer. Edema in the stroma, density of inflammatory cells and blood vessels, presence of fibroblasts, and changes in collagen fibers in the EAC were evaluated in five different areas to obtain the area of highest concentration and classified into four grades (0=no change, 1=mild, 2=moderate, 3=severe). RESULTS:The higher concentration of TO (0.4%) was more effective than dexamethasone and 0.1% TO with respect to antibacterial and the anti-inflammatory properties. CONCLUSION: TO, particularly at a concentration of 0.4%, may be considered for topical application alone in the treatment of AOE, without any requirement for a combined treatment.en_US
dc.identifier.doi10.5152/iao.2017.4213
dc.identifier.endpage289en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.pmid29283096en_US
dc.identifier.scopus2-s2.0-85053717140en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.5152/iao.2017.4213
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12570
dc.identifier.volume14en_US
dc.identifier.wosWOS:000456115400023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of International Advanced Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectacute otitis externaen_US
dc.subjecttreatmenten_US
dc.subjectexperimental studyen_US
dc.titleThe Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Ratsen_US
dc.typeArticleen_US

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