The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

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dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.authoridIyigun, Suleyman Serhat/0000-0002-3270-1931
dc.authoridHatipoglu, Fatih/0000-0002-0103-5868
dc.authoridATES, Mehmet Burak/0000-0003-1297-426X
dc.contributor.authorOk, Mahmut
dc.contributor.authorNaseri, Amir
dc.contributor.authorAtes, Mehmet Burak
dc.contributor.authorIder, Merve
dc.contributor.authorUney, Kamil
dc.contributor.authorSevinc, Mutlu
dc.contributor.authorHatipoglu, Fatih
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSimple Summary The objective of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy calves and 25 calves with perinatal asphyxia were enrolled in the study. Consciousness evaluation and laboratory analyses were performed at admission, 24, 48, and 72 h. Serum concentrations of brain-related biomarkers were measured to assess brain injury. Moreover, histopathological and immunohistochemical examinations of the brain tissue were performed in 13 nonsurvivor calves. The consciousness level of the calves with asphyxia was significantly lower than the healthy calves. Mix metabolic-respiratory acidosis and hypoxemia were detected in calves with asphyxia. Serum UCHL1 and S100B concentrations were significantly increased, and NSE, ACTA, ADM, and CK-B were decreased in calves with asphyxia. Histopathological and immunohistochemical examination in nonsurvivor calves confirmed the development of mild to severe hypoxic-ischemic encephalopathy. In conclusion, asphyxia causes hypoxic ischemic encephalopathy in perinatal calves. UCHL1 and S100B were found to be useful markers of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction. The purpose of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy and 25 calves with perinatal asphyxia were enrolled in the study. Clinical examination, neurological status score, and laboratory analysis were performed at admission, 24, 48, and 72 h. Serum concentrations of ubiquitin carboxy-terminal hydrolysis 1 (UCHL1), calcium-binding protein B (S100B), adrenomodullin (ADM), activitin A (ACTA), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and creatine kinase-brain (CK-B) were measured. Histopathological and immunohistochemical examinations of the brain tissue were performed in 13 nonsurvivor calves. The neurological status score of the calves with asphyxia was significantly (p < 0.05) lower. Mix metabolic-respiratory acidosis and hypoxemia were detected in calves with asphyxia. Serum UCHL1 and S100B were significantly (p < 0.05) increased, and NSE, ACTA, ADM, and CK-B were decreased (p < 0.05) in calves with asphyxia. Histopathological and immunohistochemical examinations confirmed the development of mild to severe hypoxic-ischemic encephalopathy. In conclusion, asphyxia and hypoxemia caused hypoxic-ischemic encephalopathy in perinatal calves. UCHL1 and S100B concentrations were found to be useful markers for the determination of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUB.ITAK) [220O013]en_US
dc.description.sponsorshipThis research was funded by The Scientific and Technological Research Council of Turkiye (TUB.ITAK), grant number 220O013.en_US
dc.identifier.doi10.3390/ani12223223
dc.identifier.issn2076-2615
dc.identifier.issue22en_US
dc.identifier.pmid36428450en_US
dc.identifier.scopus2-s2.0-85142421805en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ani12223223
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11638
dc.identifier.volume12en_US
dc.identifier.wosWOS:000887020900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofAnimalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectperinatal asphyxiaen_US
dc.subjectcalfen_US
dc.subjectbrain damageen_US
dc.subjectserum biomarkersen_US
dc.subjectmortalityen_US
dc.titleThe Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxiaen_US
dc.typeArticleen_US

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