Perioperative Effects of Induction with High-dose Rocuronium during Laparoscopic Cholecystectomy

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dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorTunc, Mehmet
dc.contributor.authorOksar, Menekse
dc.contributor.authorTemiz, Muhyittin
dc.date.accessioned2024-09-18T20:08:22Z
dc.date.available2024-09-18T20:08:22Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the effects of high-dose rocuronium administration on intra-abdominal pressure (IAP) and surgical conditions during anaesthesia induction and laparoscopic cholecystectomy anaesthesia induction, respectively. Further, we aimed to determine postoperative nausea and vomiting (PONV) and pain scores following the laparoscopic cholecystectomy. Methods: Patients with American Society of Anesthesiologists (ASA) score of I-III, aged 18 to 75 years and who were scheduled for surgery under general anaesthesia were included in the study. Patients were randomised and a high-dose of 1.2 mg kg(-1) rocuronium was given to Group A and 0.6 mg kg(-1) rocuronium to Group B. The intraoperative train of four (TOF) ratio and post-tetanic count (PTC) were measured. Surgery was initiated with a low IAP of 7 mmHg. The surgeon evaluated surgical conditions with a 4-step surgical field scale and increased the IAP when necessary. PONV at 4, 12 and 24 hours and postoperative pain at 2 and 24 hours and 3 days were evaluated. Results: There were no significant differences in the demographic and haemodynamic parameters between the groups. In high-dose rocuronium Group A, IAP values were significantly lower in the first 20 minutes compared to Group B. The duration of operations was significantly shorter in Group A (29.00 +/- 7.39 minute vs. 34.63 +/- 12.00 minute, p=0.044). PONV in the first 12 hours was significantly lower in Group A (p<0.05). Conclusion: High-dose rocuronium-induced deep neuromuscular block helped perform laparoscopic cholecystectomy operations with lower values of IAP compared to a normal dose rocuronium. It also shortened duration of operation and reduced PONV and pain.en_US
dc.identifier.doi10.5152/TJAR.2019.31855
dc.identifier.endpage195en_US
dc.identifier.issn2667-6370
dc.identifier.issue3en_US
dc.identifier.pmid32551445en_US
dc.identifier.scopus2-s2.0-85085884271en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage188en_US
dc.identifier.trdizinid411066en_US
dc.identifier.urihttps://doi.org/10.5152/TJAR.2019.31855
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/411066
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8796
dc.identifier.volume48en_US
dc.identifier.wosWOS:000538479400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Anaesthesiology and Reanimationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCholecystectomyen_US
dc.subjectlaparoscopicen_US
dc.subjectnausea vomitingen_US
dc.subjectneuromuscular blockadeen_US
dc.subjectpainen_US
dc.subjectpostoperativeen_US
dc.subjectrocuroniumen_US
dc.titlePerioperative Effects of Induction with High-dose Rocuronium during Laparoscopic Cholecystectomyen_US
dc.typeArticleen_US

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