Examination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virus

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dc.contributor.authorCabalak, Mehmet
dc.contributor.authorBal, Tayibe
dc.contributor.authorPolat, Eda Selin
dc.contributor.authorOcak, Sabahattin
dc.contributor.authorOnlen, Yusuf
dc.date.accessioned2024-09-18T20:26:43Z
dc.date.available2024-09-18T20:26:43Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Highly active antiretroviral therapy (HAART) has significantly reduced morbidity and mortality in patients infected with Human immunodeficiency virus (HIV). Despite this success, the sustainability of the initial treatment regimen has become difficult as patients continue the treatment for life. Highly active antiretroviral therapy regimen change may often be necessary due to intolerance/toxicity, pregnancy, comorbidities, difficulty in patient compliance and failure to achieve virological suppression. In this study, it was aimed to examine the reasons for HAART change in patients followed up for HIV/AIDS in Hatay Mustafa Kemal University, Tayfur Ata Sokmen Faculty of Medicine Hospital. Materials and Methods: In this retrospective, cross-sectional, single-center study, 151 patients followed up at Hatay Mustafa Kemal University, Tayfur Ata Sokmen Medical Faculty Hospital for HIV between January 2018 and December 2020 were included in the study. Results: One hundred-seventeen (77.5%) of the cases were male and 34 (22.5%) were female. The mean age was 39.08 +/- 14.2 years (20-83). Treatment changes were made in 35 (23.2%) of the cases. The most common reason for treatment change was intolerance/toxicity (19) in 12.6% of cases. Other reasons for change; pregnancy was six (4%), treatment non-compliance was four (2.6%), patient request was three (2%), and physician decision was three (2%). No drug changes were detected in the cases due to virological failure. Conclusion: There is generally little data available in Turkey on the reasons for regime change in HIV patients using HAART. Therefore, the data we will obtain in this study can help draw a long-term plan for HAART drug management.en_US
dc.identifier.doi10.4274/mjima.galenos.2023.2022.2
dc.identifier.issn2147-673X
dc.identifier.scopus2-s2.0-85168583250en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.trdizinid1169988en_US
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2023.2022.2
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1169988
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10497
dc.identifier.volume12en_US
dc.identifier.wosWOS:000996015400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHIVen_US
dc.subjecthighly active antiretroviral therapyen_US
dc.subjectchange in therapyen_US
dc.titleExamination of the Reasons for Change in Treatment in Patients Infected with Human Immunodeficiency Virusen_US
dc.typeArticleen_US

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