Uric Acid and Multiple Myeloma, Unexplored Association

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dc.contributor.authorKaçmaz, Murat
dc.contributor.authorBaşcı, Semih
dc.contributor.authorYaman, Samet
dc.contributor.authorCandir, Burcu Aslan
dc.contributor.authorSeçilmiş, Sema
dc.contributor.authorİlhan, Gül
dc.contributor.authorYiğenoğlu, Tuğçe Nur
dc.date.accessioned2024-09-19T16:26:49Z
dc.date.available2024-09-19T16:26:49Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Multiple Myeloma (MM) is a common hematological malignancy and various factors affect survival. Uric acid (UA) is an easily and quickly accessible laboratory test. UA has been found to affect prognosis and survival in many hematological diseases and its impact on myeloma is not widely investigated. Methods: Our retrospective study includes 106 MM patients between 2014 and 2021. The influence of UA level at diagnosis on treatment outcomes and survival of patients who received autologous stem cell transplantation (ASCT) was investigated. Results: The mean UA at diagnosis was 6.05 mg/dL, and 38.7% of our cohort relapsed after a median of 30 months of follow-up, with 22.7% dead. In survival analysis, the level of UA did not significantly differ in both progression-free survival (PFS) and overall survival (OS) (HR, 1.067; 95% CI, 0.947-1.202; p=0.290, HR, 0.941; 95% CI, 0.791-1.121; p=0.497, respectively). Discussion and Conclusion: In our study, regardless of the cut-off value for the UA level at the time of diagnosis, the UA level had no impact on PFS or OS in MM patients who received ASCT.en_US
dc.identifier.doi10.5505/aot.2023.25901
dc.identifier.endpage52en_US
dc.identifier.issn0304-596X
dc.identifier.issn2148-7669
dc.identifier.issue1en_US
dc.identifier.startpage46en_US
dc.identifier.trdizinid1177920en_US
dc.identifier.urihttps://doi.org/10.5505/aot.2023.25901
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1177920
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16379
dc.identifier.volume56en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofACTA ONCOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleUric Acid and Multiple Myeloma, Unexplored Associationen_US
dc.typeArticleen_US

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