Evaluation of Liver Fibrosis in Polycystic Ovary Syndrome by Shear Wave Elastography, FIB-4 Score, and Serum Periostin Levels

Basit Öğe Kaydı
dc.contributor.authorGürkan, Eren
dc.contributor.authorAslan, Gökçen
dc.contributor.authorBurakgazi, Gülen
dc.contributor.authorÖzcan, Oğuzhan
dc.date.accessioned2024-09-19T16:25:13Z
dc.date.available2024-09-19T16:25:13Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to demonstrate the presence of liver fibrosis in patients with poly- cystic ovary syndrome at a relatively early stage of the disease using biochemical data and 2-dimen- sional shear wave elastography techniques. Methods: The study included 33 women with polycystic ovary syndrome and 33 healthy women volunteers. Serum androgen and sex hormone binding globulin levels were measured, and then free androgen index was calculated. Periostin and matrix metalloproteinase-3 levels were measured by ELISA method. Sterling formula was used to calculate FIB-4 score. Liver elasticity was evaluated using shear wave elastography. Results: Periostin and matrix metalloproteinase-3 levels were found to be significantly higher in the polycystic ovary syndrome group compared to the control group (P < .001 and P < .001, respectively). Serum testosterone level and free androgen index were also significantly higher in the polycystic ovary syndrome group (P = .044 and P = .037, respectively). However, there was no significant differ- ence between the groups in terms of liver velocity and elasticity (P = .185 and P = .172, respectively). A positive correlation was found between FIB-4 score and periostin (r = 0.433, P = .012) and between FIB-4 score and liver elasticity in the PCOS group (r = 0.374, P = .032). Conclusion: FIB-4 score was positively correlated with periostin and liver elasticity. These data sug- gest that in addition to FIB-4 score, serum periostin level and shear wave elastography may help us clinically in the detection of liver fibrosis at patients with polycystic ovary syndrome.en_US
dc.identifier.doi10.5152/erp.2023.22104144
dc.identifier.endpage84en_US
dc.identifier.issn2822-6135
dc.identifier.issue2en_US
dc.identifier.startpage78en_US
dc.identifier.trdizinid1178942en_US
dc.identifier.urihttps://doi.org/10.5152/erp.2023.22104144
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1178942
dc.identifier.urihttps://hdl.handle.net/20.500.12483/16293
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEndocrinology research and practiceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of Liver Fibrosis in Polycystic Ovary Syndrome by Shear Wave Elastography, FIB-4 Score, and Serum Periostin Levelsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
16293.pdf
Boyut:
1.36 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu