The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits

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dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorGülay, Mehmet Şükrü
dc.date.accessioned2024-09-19T16:22:22Z
dc.date.available2024-09-19T16:22:22Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBisphenol AF (BPAF) is used as an analog of the endocrine disruptor Bisphenol A (BPA), whereas safranal is a powerful antioxidant obtained from the saffron plant. In the current study, the possible effects of BPAF and Safranal on some spermatological parameters, reproductive hormones, oxidant/antioxidant enzymes, and histopathological parameters were investigated. A total of 24 male New Zealand rabbits were divided into 4 groups (n= 6 for each group). The groups and the treatments they received by oral gavage for 9 weeks are as follows: The control group received by oral gavage 1 ml/day of corn oil, the BPAF group received by oral gavage 20 mg/kg/day of bisphenol AF, the Safranal group received by oral gavage 100 mg/kg/day safranal, and the treatment group received by oral gavage 20 mg/kg/day bisphenol AF and 100 mg/kg/day safranal. Although the spermatological parameters (sperm concentration, ejaculate volume, progressive motility, ejaculate weight, seminal plasma total protein, and pH) prior to the experiment revealed no differences among the groups, BPAF treatment reduced sperm quantity and motility at the end of the study. BPAF treatments also had a negative impact on testicular MDA and GSH levels. It also caused seminiferous tubule degeneration in testicular tissue. On the other hand, the administration of safranal with BPAF decreased estrogen levels while increasing sperm concentration and motility to control group levels. Thus, the results suggested that safranal could have a beneficial effect in reducing BPAF-induced tissue damage. In conclusion, BPAF may have potentially harmful to the male reproductive system and safranal may exhibit a protective effect against BPAF exposure.en_US
dc.identifier.doi10.24880/maeuvfd.1138340
dc.identifier.endpage217en_US
dc.identifier.issn2458-9268
dc.identifier.issn2148-6239
dc.identifier.issue3en_US
dc.identifier.startpage207en_US
dc.identifier.trdizinid1150272en_US
dc.identifier.urihttps://doi.org/10.24880/maeuvfd.1138340
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1150272
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15802
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphenol AFen_US
dc.subjectmaleen_US
dc.subjectrabbiten_US
dc.subjectreproductionen_US
dc.subjectsafranalen_US
dc.titleThe effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbitsen_US
dc.typeArticleen_US

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