Investigation of the effects of diclofenac sodium in rat ovary on the number of preantral follicles by stereological methods in prenatal period

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dc.contributor.authorÇölçimen, Neşe
dc.contributor.authorRağbetli, Murat Çetin
dc.contributor.authorKara, Mikail
dc.contributor.authorArıhan, Okan
dc.contributor.authorAkyol, Veysel
dc.date.accessioned2019-07-16T16:01:36Z
dc.date.available2019-07-16T16:01:36Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFor healthy future generations pregnancy is a period in which maximum amount of attention should be given. In this period, choice, duration and dosage of medication as well as the changing physiology of the mother should be taken into account. Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that have analgesic, anti-pyretic and antiinflammatory effects. This group of drugs can be used in the treatment of the ongoing rheumatic diseases or which occur during the pregnancy period and the complications that occur due to pregnancy. We aimed to show how it affects the number of ovarium preantral follicles of newborn fetus on rats by using Diclofenac Sodium which belongs to this drug family group. Diclofenac Sodium (1 mg / kg, IM) was injected for 15 days from the 5th day of pregnancy to pregnant rats in Diclofenac Sodium group and saline (1 ml / kg, IM) was injected to the pregnant rats of the sham group at the same time period. In the 4th week after birth, ovarian tissue preparates of rat pups were stained with hematoxylin-eosin and ovarian total tissue volumes and preantral follicle counts were evaluated under light microscope. There was no statistically significant difference between groups for ovarium total tissue volumes and preantral follicle numbers (p>0.05). Lowest value of follicular intensity was observed in Diclofenac sodium group among study groups however no statistically important difference was found (p>0.05). Results obtained in our study may be related with administration of drug in not a high dosage (1mg/kg). Further studies may be performed with higher doses.en_US
dc.description.abstractFor healthy future generations pregnancy is a period in which maximum amount of attention should be given. In this period, choice, duration and dosage of medication as well as the changing physiology of the mother should be taken into account. Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that have analgesic, anti-pyretic and antiinflammatory effects. This group of drugs can be used in the treatment of the ongoing rheumatic diseases or which occur during the pregnancy period and the complications that occur due to pregnancy. We aimed to show how it affects the number of ovarium preantral follicles of newborn fetus on rats by using Diclofenac Sodium which belongs to this drug family group. Diclofenac Sodium (1 mg / kg, IM) was injected for 15 days from the 5th day of pregnancy to pregnant rats in Diclofenac Sodium group and saline (1 ml / kg, IM) was injected to the pregnant rats of the sham group at the same time period. In the 4th week after birth, ovarian tissue preparates of rat pups were stained with hematoxylin-eosin and ovarian total tissue volumes and preantral follicle counts were evaluated under light microscope. There was no statistically significant difference between groups for ovarium total tissue volumes and preantral follicle numbers (p>0.05). Lowest value of follicular intensity was observed in Diclofenac sodium group among study groups however no statistically important difference was found (p>0.05). Results obtained in our study may be related with administration of drug in not a high dosage (1mg/kg). Further studies may be performed with higher doses.en_US
dc.identifier.endpage84en_US
dc.identifier.issn1301-0883
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85031095577en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TWpVMU9EUXpNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12483/2768
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToksikolojien_US
dc.subjectDiş Hekimliğien_US
dc.subjectFarmakoloji ve Eczacılıken_US
dc.titleInvestigation of the effects of diclofenac sodium in rat ovary on the number of preantral follicles by stereological methods in prenatal perioden_US
dc.typeArticleen_US

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