Yenidoğan sarılıklarında transkutan bilirubin ölçümü ile total serum bilirubini arasındaki korelasyonun araştırılması
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Dosyalar
Tarih
2022
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Yayıncı
Hatay Mustafa Kemal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Yenidoğanlarda transkutan bilirubin (TcB) ölçümleriyle total serum bilirubinleri (TSB) ölçümleri arasındaki korelasyonu saptamayı ve TcB cihazının hiperbilirubinemi ölçümünde kullanımını değerlendirmeyi amaçladık. Gereç ve Yöntem: Bu çalışma Hatay Mustafa Kemal Üniversitesi Hastanesi Yenidoğan Yoğun Bakım Ünitesi'nde yatarak tedavi gören 114 yenidoğan bebek üzerinde yapıldı. TcB ölçümünde JM-103 marka TcB cihazı kullanıldı. Her hastada alın, sternum ve diz kapağının üzerinden 3'er ölçüm yapılıp cihazın gösterdiği ortalama alındı. Parametreler arası ilişkilerin değerlendirilmesinde Pearson ve Spearman's korelasyon analizi kullanıldı. Bulgular: Gestasyon yaşı 21 ile 39 hafta arasında değişen 114 yenidoğan bebeğe yapılan 456 ölçüm grubu (TcB-alın, TcB-sternum, TcB-diz, TSB) karşılaştırıldı. Çalışmaya katılan bireylerin TcB-Alın değerleri ortalaması 7.26±4.05 mg/dl, TcB-Sternum ortalaması 7.38±4.22 mg/dl, TcB-Diz ortalaması 3.91±3.05 mg/dl olduğu tespit edilmiştir. TSB (Kan) değerleri ortalaması ise 9.99±4.82 mg/dl'dir. TSB (Kan) değerleri ile transkutan bilirubin değerleri arasındaki korelasyona bakıldığında çok yüksek düzeyde pozitif yönlü korelasyon bulunmaktadır (ρ(Alın)= 0.981, ρ(Sternum)= 0.990, ρ(Diz)= 0.916). TcB değerleri arttıkça TSB değerleri de paralel olarak artmaktadır. Ölçüm sonuçlarını gruplandırdığımızda; TSB 0-15 mg/dl aralığında iken JM-103 ile alından ve sternumdan yapılan ölçümlerde istatistiksel anlamlı olarak (p<0,01) yüksek düzeyde korelasyon gösterdiği saptanmıştır. Serum bilirubin düzeyinin >5 mg/dl'nin üzerinde olduğu durumlarda dizden yapılan transkutan bilirubin ölçümlerinde anlamlı bir ilişkinin olmadığı bulunmuştur. Sonuç: Çalışmamız transkutan bilirubin ölçümü ile yenidoğan bebeklerde sarılık taramasının güvenli, hızlı ve kolay bir şekilde yapılabileceğini ve düşük riskli bebeklerin tespit edilebileceğini gösterdi. Ayrıca yenidoğanlarda serum bilirubini takibinde gereksiz kan alma işlemini azaltacağı sonucuna varıldı. Ancak bu konuda farklı toplumlarda yapılacak cutoff değerlerini belirleyen çalışmalara ihtiyaç vardır.
Objective: We aimed to determine the correlation between transcutaneous bilirubin (TcB) measurements and total serum bilirubin (TSB) measurements in newborns and to evaluate the use of TcB device in the measurement of hyperbilirubinemia. Materials and Methods: This study was conducted on 114 newborn babies who were hospitalized in the Newborn Intensive Care Unit of Mustafa Kemal University Training and Research Hospital. JM-103 brand TcB device was used for TcB measurement. In each patient, 3 measurements were made on the forehead, sternum and kneecap and the average indicated by the device was taken. Pearson and Spearman's correlation analysis was used to evaluate the relationships between parameters. Significance was evaluated at the p<0.05 level. Results: 456 measurement groups (JM-103(forehead), JM-103(sternum), JM- 103(knee), TSB) performed on 114 newborn babies between 21 and 39 weeks of gestation were statistically compared. The mean TcB-Forehead values of the individuals participating in the study were 7.26±4.05 mg/dl, the mean TcB-Sternum was 7.38±4.22 mg/dl, and the mean TcB-Knee was 3.91±3.05 mg/dl. The mean TSB (Blood) values are 9.99±4.82 mg/dl. When the correlation between TSB (Blood) values and transcutaneous bilirubin values is considered, there is a very high positive and statistically significant relationship (ρ(Forehead)= 0.981, ρ(Sternum)= 0.990, ρ (Knee)= 0.916 ). As TcB values increase, TSB values increase in parallel. When we group the measurement results; When TSB was in the range of 0-15 mg/dl, it was found that there was a statistically significant (p<0.01) high correlation in the measurements made with JM-103 on the forehead and sternum. It was found that there was no significant relationship in transcutaneous bilirubin measurements made from the knee in cases where the serum bilirubin level was >5 mg/dl (p>0.05). Conclusion: Our study showed that jaundice screening in newborn babies can be performed safely, quickly and easily, and low-risk babies can be detected with transcutaneous bilirubin measurement. In addition, it was concluded that monitoring of serum bilirubin in newborns will reduce unnecessary blood collection. However, there is a need for studies that determine the cutoff values to be made in different societies.
Objective: We aimed to determine the correlation between transcutaneous bilirubin (TcB) measurements and total serum bilirubin (TSB) measurements in newborns and to evaluate the use of TcB device in the measurement of hyperbilirubinemia. Materials and Methods: This study was conducted on 114 newborn babies who were hospitalized in the Newborn Intensive Care Unit of Mustafa Kemal University Training and Research Hospital. JM-103 brand TcB device was used for TcB measurement. In each patient, 3 measurements were made on the forehead, sternum and kneecap and the average indicated by the device was taken. Pearson and Spearman's correlation analysis was used to evaluate the relationships between parameters. Significance was evaluated at the p<0.05 level. Results: 456 measurement groups (JM-103(forehead), JM-103(sternum), JM- 103(knee), TSB) performed on 114 newborn babies between 21 and 39 weeks of gestation were statistically compared. The mean TcB-Forehead values of the individuals participating in the study were 7.26±4.05 mg/dl, the mean TcB-Sternum was 7.38±4.22 mg/dl, and the mean TcB-Knee was 3.91±3.05 mg/dl. The mean TSB (Blood) values are 9.99±4.82 mg/dl. When the correlation between TSB (Blood) values and transcutaneous bilirubin values is considered, there is a very high positive and statistically significant relationship (ρ(Forehead)= 0.981, ρ(Sternum)= 0.990, ρ (Knee)= 0.916 ). As TcB values increase, TSB values increase in parallel. When we group the measurement results; When TSB was in the range of 0-15 mg/dl, it was found that there was a statistically significant (p<0.01) high correlation in the measurements made with JM-103 on the forehead and sternum. It was found that there was no significant relationship in transcutaneous bilirubin measurements made from the knee in cases where the serum bilirubin level was >5 mg/dl (p>0.05). Conclusion: Our study showed that jaundice screening in newborn babies can be performed safely, quickly and easily, and low-risk babies can be detected with transcutaneous bilirubin measurement. In addition, it was concluded that monitoring of serum bilirubin in newborns will reduce unnecessary blood collection. However, there is a need for studies that determine the cutoff values to be made in different societies.
Açıklama
Anahtar Kelimeler
Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases, Yenidoğan hiperbilirubinemisi, JM-103, transkutan bilirubin, Newborn, hyperbilirubinemia, JM-103, transcutaneous bilirubin
