Relationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients

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dc.authoridcabalak, mehmet/0000-0003-1148-2247
dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.authoridBegen, Mehmet/0000-0001-7573-0882
dc.contributor.authorDogan, Serdar
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorBal, Tayibe
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorBegen, Mehmet A.
dc.date.accessioned2024-09-18T20:04:29Z
dc.date.available2024-09-18T20:04:29Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: Roles of Thrombospondin-1 (TSP-1) and Thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear. We investigate the roles of TSP-1 and TSP-2 in COVID-19. Methods: 106 SARS-CoV-2 infected patients and 23 healthy people were enrolled in our study. COVID-19 patients were divided into two groups as non-severe and severe. TSP-1 and TSP-2 concentrations were measured with an enzyme-linked Immunosorbent Assay, and blood markers were analyzed with routine laboratory techniques. Results: COVID-19 patients had significantly higher TSP-1 and TSP-2 levels than healthy controls. TSP-1 and TSP-2 positively correlated with inflammatory markers, including ESR, CRP, PCT, ferritin, and biochemical parameters such as ALT, AST, BUN, CK, and LDH. In addition, TSP-1 and TSP-2 were negatively correlated with hematological markers such as LYM, EOS, and HGB. Receiver operating characteristic analyses revealed that COVID-19 may be predicted with TSP-1 levels over 189.94 ng/mL and TSP-2 levels higher than 0.70 ng/mL. Conclusions: Our analysis suggests that TSP-1 and TSP-2 expressions at the systemic level may have clinical importance for COVID-19.en_US
dc.identifier.doi10.1515/tjb-2022-0265
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.scopus2-s2.0-85173871650en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.trdizinid1252069en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0265
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1252069
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8205
dc.identifier.wosWOS:001019169100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiomarkeren_US
dc.subjectCOVID-19en_US
dc.subjectinflammationen_US
dc.subjectThrombospondin-1en_US
dc.subjectThrombospondin-2en_US
dc.titleRelationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patientsen_US
dc.typeArticleen_US

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