Dose-dependent effects of simvastatin, atorvastatin and rosuvastatin on apoptosis and inflammation pathways on cancerous lung cells

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dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.authoridCimen Acikgul, Funda/0000-0002-8904-1444
dc.authoridDuran, Nizami/0000-0002-2766-3491
dc.authoridCamdeviren, Baran/0000-0003-1508-7869
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorDikmen, Nursel
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorCimen Acikgul, Funda
dc.contributor.authorCamdeviren, Baran
dc.contributor.authorAy, Emrah
dc.contributor.authorAmbarcioglu, Pinar
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-18T20:02:33Z
dc.date.available2024-09-18T20:02:33Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of study was to investigate the anti-proliferative and inflammatory effects of atorvastatin, rosuvastatin, and simvastatin in lung cancer. The effects of statins were investigated in Vero, BEAS-2B, and A549 cell lines. In addition to expressions of BAX, BCL-2, TNF alpha, IL-10, IL-6, protein levels of TNF alpha, IL-10, IL-6 were determined. Cell viability and MDA were also measured. While the cell numbers in groups with low doses of statins were found to be approximately 1x106/mL, proliferation was inhibited at higher rates containing high doses. Simvastatin, rosuvastatin, and high dose atorvastatin upregulated the BAX, while high dose of atorvastatin and both doses of rosuvastatin caused downregulation in BCL-2. All statin groups had higher MDA. Simvastatin and high dose rosuvastatin upregulated TNF alpha. While low dose simvastatin and atorvastatin and high dose atorvastatin and rosuvastatin upregulated IL-10, IL6 was upregulated with a low dose of rosuvastatin. TNF alpha was higher in simvastatin and rosuvastatin groups. IL-10 was highest in rosuvastatin groups. Atorvastatin groups had lower IL-6. Although cell numbers have been reduced by all statins, rosuvastatin is more effective on studied genes.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Hatay Mustafa Kemal University [20]en_US
dc.description.sponsorshipFinancial Support This study was financially supported by the Scientific Research Projects Coordination of Hatay Mustafa Kemal University (Project number: 20.M.017) .en_US
dc.identifier.doi10.33988/auvfd.938418
dc.identifier.endpage148en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85152253817en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.trdizinid1177894en_US
dc.identifier.urihttps://doi.org/10.33988/auvfd.938418
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1177894
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7862
dc.identifier.volume70en_US
dc.identifier.wosWOS:000957950300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAnkara Univen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectAtorvastatinen_US
dc.subjectLung canceren_US
dc.subjectRosuvastatinen_US
dc.subjectSimvastatinen_US
dc.titleDose-dependent effects of simvastatin, atorvastatin and rosuvastatin on apoptosis and inflammation pathways on cancerous lung cellsen_US
dc.typeArticleen_US

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