COMPARISON OF THE EFFECTS OF OMEGA 3 AND PROBIOTICS ON ALVEOLAR BONE LOSS IN RATS: AN IMMUNOHISTOCHEMICAL STUDY

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dc.contributor.authorDoğan, Burak
dc.contributor.authorDoğan, Esra Sinem Kemer
dc.contributor.authorÖzmen, Özlem
dc.date.accessioned2024-09-19T16:22:06Z
dc.date.available2024-09-19T16:22:06Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Omega 3 and probiotics have been demonstrated to have beneficial effects in periodontal disease pathogenesis. Induciblenitric oxide synthase is an important mediator regulating immune response. The objective of this study was to compare theimpacts of omega 3 and probiotic supplementation on alveolar bone loss and gingival inducible nitric oxide synthase levels in anexperimental periodontitis model.Material and Methods: Thirty-two rats were separated into 4 equal groups as control, periodontitis, omega 3, and probiotic.Omega 3 or probiotic was supplemented by oral gavage and experimental periodontitis was induced to the rats in periodontitis,omega 3, and probiotic groups by ligature. Alveolar bone loss was measured histometrically. The number of neutrophils wascounted and gingival inducible nitric oxide synthase levels were analysed immunohistochemically.Results: Alveolar bone loss significantly increased in periodontitis induced groups, compared to control group and decreased inomega 3 and probiotic groups, compared to the periodontitis group (p <0.05). Probiotic group had further decrease in alveolarbone loss than the omega 3 group (p <0.05). The number of neutrophils and gingival inducible nitric oxide synthase levels werehigher in the periodontitis, omega 3, and probiotic groups than those in the control group, and decreased in omega 3 andprobiotic groups, compared to the periodontitis group (p <0.05).Conclusion: We suggest that omega 3 and probiotic administrations could reduce alveolar bone loss by decreasing gingivalinducible nitric oxide synthase. Probiotic support seems to have more beneficial reducing alveolar bone loss, compared toomega 3.en_US
dc.identifier.doi10.17567/ataunidfd.860173
dc.identifier.endpage174en_US
dc.identifier.issn1300-9044
dc.identifier.issue2en_US
dc.identifier.startpage167en_US
dc.identifier.trdizinid447318en_US
dc.identifier.urihttps://doi.org/10.17567/ataunidfd.860173
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/447318
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15599
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAtatürk Üniversitesi Diş Hekimliği Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCOMPARISON OF THE EFFECTS OF OMEGA 3 AND PROBIOTICS ON ALVEOLAR BONE LOSS IN RATS: AN IMMUNOHISTOCHEMICAL STUDYen_US
dc.typeArticleen_US

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