Oxidative stress markers in IVF patients and their association with pregnancy results

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dc.authorscopusid56185523700
dc.authorscopusid7006409671
dc.authorscopusid35204100300
dc.authorscopusid56798833200
dc.authorscopusid56185523800
dc.authorscopusid7005541487
dc.contributor.authorGüler Okyay, Ayşe
dc.contributor.authorAslan, Mehmet
dc.contributor.authorTaşkin, Abdullah
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorCeng Altin, Günseliiz
dc.contributor.authorKahraman, Semra
dc.date.accessioned2024-09-19T15:48:34Z
dc.date.available2024-09-19T15:48:34Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Oxidative stress has been well recognized as a component in the pathogenesis of many diseases, including female infertility. In this study, we aimed to investigate serum paraoxonase (PON1), arylesterase and myeloperoxidase (MPO) activities, and lipid hydroperoxide (LOOH) levels as oxidative stress markers along with their relationship with the pregnancy rate in women undergoing in vitro fertilization (IVF) treatment. Material and Methods: Serum samples of 179 subjects were collected immediately before starting ovarian stimulation and on ovum pick-up (OPU) day during IVF treatment. Stimulation protocol and starting doses were determined individually. When the leading follicle reached at least 17 mm in size, recombinant human chorionic gonadotropin (Ovitrelle, 250 mcg, Serono) was administered for ovulation induction. Serum basal/salt-stimulated paraoxonase, arylesterase activities, myeloperoxidase activity, and lipid hydroperoxide levels were compared between two samples. Subjects were also divided into two groups according to the presence of pregnancy, and the groups were compared in terms of oxidative stress markers studied. Results: Serum MPO activity and LOOH levels were significantly higher on ovum pick up day (p<0.05, p<0.001, respectively), while basal/salt-stimulated paraoxonase and arylesterase activities were significantly lower (p=0.012, p=0.041, respectively) than those before ovarian stimulation. Serum LOOH levels on OPU day were significantly higher in non-pregnant group than pregnant one (p<0.001). Although basal/salt-stimulated paraoxonase, arylesterase and myeloperoxidase activities were higher in the non-pregnant group compared to the pregnant group, it was not statistically significant (p>0.05). Conclusion: Ovarian stimulation during IVF treatment resulted in increased oxidative stress and decreased PON1 activity. However, changes in the studied parameters were not found to be significantly associated with the pregnancy results. Further studies are required to clarify our results. © 2014 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2013-36880
dc.identifier.endpage209en_US
dc.identifier.issn1300-0292
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84901685317en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2013-36880
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15165
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHumanen_US
dc.subjectIn vitro fertilizationen_US
dc.subjectLipid peroxidesen_US
dc.subjectPeroxidaseen_US
dc.subjectPON1 proteinen_US
dc.titleOxidative stress markers in IVF patients and their association with pregnancy resultsen_US
dc.title.alternativeIVF hastalari{dotless}nda oksidatif stres belirteçleri ve bunlari{dotless}n gebelik sonuçlari{dotless}yla Ilişkisien_US
dc.typeArticleen_US

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