Whole-Genome Sequencing-Based Characterization of Listeria monocytogenes from Food and Animal Clinical Cases

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dc.contributor.authorAslantas, Ozkan
dc.contributor.authorBuyukaltay, Kaan
dc.contributor.authorKeskin, Oktay
dc.contributor.authorGullu Yucetepe, Ayfer
dc.contributor.authorAdiguzel, Adem
dc.date.accessioned2024-09-18T20:25:10Z
dc.date.available2024-09-18T20:25:10Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractListeriosis is a rare but severe foodborne infection caused by Listeria monocytogenes. In this study, we performed comparative whole-genome sequencing (WGS) on 28 Listeria monocytogenes from seven invasive listeriosis cases in animals and 21 food samples in Turkiye for the first time. Food isolates were delineated into eleven clonal complexes (CCs), namely CC1, CC2, CC3, CC8, CC9, CC20, CC69, CC124, CC155, CC204, ST3002. The isolates from meningoencephalitis cases were associated with CC1, whereas CC9 and CC7 were associated with the isolates from sheep abortus cases. All the isolates carried the fosX, lin, norB, and sul genes. In addition, emrC (n=15), bcrC (n=4), emrE (n=2), qacA (n=1), cadA (n=5) and cadC (n=1) genes, conferring resistance to stress and disinfectants were detected. Listeria pathogenicity island (LIPI)-1 and LIPI-2 were distributed in all isolates, but LIPI-3 was closely related to CC1, CC3, and ST3002 isolates. LIPI-4 was not found in any of the L. monocytogenes isolates. The Inc18(rep25) and Inc18(rep26) plasmids were found in 16 (57.1%) isolates. A total of 15 different intact prophage genomes ranging from one to three were detected in the genomes of 24 isolates. The hypervirulent CC1 and CC2 clones that pose a significant threat to food safety and public health were detected among food isolates. These findings highlight the importance of continuous surveillance of hypervirulent L. monocytogenes strains in different settings.en_US
dc.description.sponsorshipScientific Research Fund of Hatay Mustafa Kemal University [21.GAP.051]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Hatay Mustafa Kemal University with a grant number of 21.GAP.051.en_US
dc.identifier.doi10.9775/kvfd.2023.28970
dc.identifier.endpage230en_US
dc.identifier.issn1300-6045
dc.identifier.issn1309-2251
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85163187164en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage221en_US
dc.identifier.trdizinid1185756en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2023.28970
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1185756
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10128
dc.identifier.volume29en_US
dc.identifier.wosWOS:000981547300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFooden_US
dc.subjectGenetic diversityen_US
dc.subjectInvasive infectionen_US
dc.subjectListeria monocytogenesen_US
dc.subjectWhole Genome Sequencingen_US
dc.titleWhole-Genome Sequencing-Based Characterization of Listeria monocytogenes from Food and Animal Clinical Casesen_US
dc.typeArticleen_US

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