Effects of tranexamic acid on amount of hemorrhage in rats with splenic laceration
[ N/A ]
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The purpose of this study is to evaluate whether administration of tranexamic acid (TNA), an anti-fibrinolytic drug, would decrease amount of bleeding on splenic laceration model in rats. Fourteen Sprague-Dawley male rats were randomly divided into two groups each contain 7 rats. Group 1 was splenic laceration + %0.9 NaCl infusion; group 2 was splenic laceration + %0.9 NaCl infusion + TNA treatment. All rats were sacrificed at the end of 60 minutes. The groups were evaluated in terms of hematocrite changes and the amount of intra-abdominal blood accumulations. There were significant difference between preoperative and post-operative hematocrite (Hct-1 and Hct-2, respectively) levels of the two groups (p<0.05). Hct-2 level of group 2 was higher than that of group 1, but it was not significantly important (P=0.097). Blood loss of rats in group 2 was less than in group 1, but it was not significantly important (P=0.073), as well. We can say that using TNA has a tendency, although not statistically significant, to decrease of intraperitoneal hemorrhage from a lacerated spleen in rats. This treatment method may yield better results when used in other animal species which have similar coagulation properties with human. © 2009 OMÜ Tüm Haklari Saklidir.
Açıklama
Anahtar Kelimeler
Acide, Antifibrinolytic, Hemorrhage, Hemostasis, Spleen, Tranexamic, Trauma
Kaynak
Journal of Experimental and Clinical Medicine (Turkey)
WoS Q Değeri
Scopus Q Değeri
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Cilt
26
Sayı
4
