Effects of tranexamic acid on amount of hemorrhage in rats with splenic laceration

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dc.authorscopusid56251336100
dc.authorscopusid19933417600
dc.authorscopusid57214471494
dc.authorscopusid23095569900
dc.contributor.authorAkçora, Bülent
dc.contributor.authorAltu?, Muhammed Enes
dc.contributor.authorÖztürk, Atakan
dc.contributor.authorÖzer, Cahit
dc.date.accessioned2024-09-19T15:41:23Z
dc.date.available2024-09-19T15:41:23Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this study is to evaluate whether administration of tranexamic acid (TNA), an anti-fibrinolytic drug, would decrease amount of bleeding on splenic laceration model in rats. Fourteen Sprague-Dawley male rats were randomly divided into two groups each contain 7 rats. Group 1 was splenic laceration + %0.9 NaCl infusion; group 2 was splenic laceration + %0.9 NaCl infusion + TNA treatment. All rats were sacrificed at the end of 60 minutes. The groups were evaluated in terms of hematocrite changes and the amount of intra-abdominal blood accumulations. There were significant difference between preoperative and post-operative hematocrite (Hct-1 and Hct-2, respectively) levels of the two groups (p<0.05). Hct-2 level of group 2 was higher than that of group 1, but it was not significantly important (P=0.097). Blood loss of rats in group 2 was less than in group 1, but it was not significantly important (P=0.073), as well. We can say that using TNA has a tendency, although not statistically significant, to decrease of intraperitoneal hemorrhage from a lacerated spleen in rats. This treatment method may yield better results when used in other animal species which have similar coagulation properties with human. © 2009 OMÜ Tüm Haklari Saklidir.en_US
dc.identifier.endpage172en_US
dc.identifier.issn1300-2996
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-80053645917en_US
dc.identifier.scopusquality#BAŞV!en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14230
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcideen_US
dc.subjectAntifibrinolyticen_US
dc.subjectHemorrhageen_US
dc.subjectHemostasisen_US
dc.subjectSpleenen_US
dc.subjectTranexamicen_US
dc.subjectTraumaen_US
dc.titleEffects of tranexamic acid on amount of hemorrhage in rats with splenic lacerationen_US
dc.title.alternativeDalak laserasyonu oluşturulmuş siçanlarda traneksamik asit'in kanama miktari üzerindeki etkilerien_US
dc.typeArticleen_US

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