Effect of Pro-Inflammatory Cytokine IL-1?, on Urotensin II Gene Expression in Human Lung Cancer Cells

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorGuneri, Cansu Onlen
dc.contributor.authorKucuk, Meral Urhan
dc.date.accessioned2024-09-18T21:00:30Z
dc.date.available2024-09-18T21:00:30Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Lung cancer is the deadliest cancer type world-wide. Poor prognosis of lung cancer patients and lack of an effective treatment require detailed understanding of lung cancer pathogenesis. It was highlighted in some studies that U-II is likely to be a biomarker or molecular target for the prevention and treatment of some diseases such as lung cancer. But its molecular action mechanism has not been elucidated yet. In the present study, we aimed to investigate the role of U-II in lung cancer. Methods: In our study, A549 cells were induced with different doses of IL-1 beta at different durations (1, 3 ng/ml; 6, 24 hours). mRNA levels of GAPDH, NF-kappa B1, MMP-1, and U-II were analyzed with RT-qPCR. The Delta Delta Ct (Delta Delta Ct) method was used for data analysis. The analyzed data were expressed as the fold-change. Results: Our results indicate that U-II gene is expressed in A549 cells and IL-1 beta can induce gene expressions of U-II, MMP-1 and NF-kappa B1 in A549 cells. Conclusions: U-II is a promising molecular target in treatment and prevention of lung cancer. Therefore, further studies are needed to enlighten molecular mechanism of U-II in lung adenocarcinoma.en_US
dc.identifier.doi10.18521/ktd.398669
dc.identifier.endpage359en_US
dc.identifier.issn1309-3878
dc.identifier.issue3en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.398669
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12726
dc.identifier.volume10en_US
dc.identifier.wosWOS:000450536200016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDuzce Univen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrotensin IIen_US
dc.subjectIL-1 betaen_US
dc.subjectNF-kappa B1en_US
dc.subjectMMP-1en_US
dc.subjectLung Canceren_US
dc.titleEffect of Pro-Inflammatory Cytokine IL-1?, on Urotensin II Gene Expression in Human Lung Cancer Cellsen_US
dc.typeArticleen_US

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