Cardioprotective effect of oleuropein in a cisplatin-induced cardiotoxicity model in rats
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Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
This study investigated the cardioprotective effect of oleuropein against cisplatin-induced cardiac damage in terms of inflammatory, oxidative stress and cardiac parameters. In this study, 40 female Wistar albino rats were divided into four groups: control, cisplatin, oleuropein and cisplatin+oleuropein. To establish the experimental model, oleuropein (200 mg/kg) was administered for 14 days and cisplatin (7 mg/kg) was administered as a single dose on the seventh day. Cisplatin increased MDA cardiac parameters (CK, CK-MB and cTnI) and inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in cardiac tissue and decreased GSH, GSH-Px and catalase levels. On the other hand, oleuropein improved cardiac parameters and decreased inflammatory cytokine and oxidative stress levels in cardiac tissue.
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Keywords
Cisplatin, Oleuropein, Cardioprotective effect, Rat
Journal or Series
Naunyn-Schmiedebergs Archives of Pharmacology
WoS Q Value
Q2
Scopus Q Value
Q2
Volume
397
Issue
5
