Cardioprotective effect of oleuropein in a cisplatin-induced cardiotoxicity model in rats

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dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.contributor.authorGokcek, Ishak
dc.date.accessioned2024-09-18T20:11:28Z
dc.date.available2024-09-18T20:11:28Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study investigated the cardioprotective effect of oleuropein against cisplatin-induced cardiac damage in terms of inflammatory, oxidative stress and cardiac parameters. In this study, 40 female Wistar albino rats were divided into four groups: control, cisplatin, oleuropein and cisplatin+oleuropein. To establish the experimental model, oleuropein (200 mg/kg) was administered for 14 days and cisplatin (7 mg/kg) was administered as a single dose on the seventh day. Cisplatin increased MDA cardiac parameters (CK, CK-MB and cTnI) and inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in cardiac tissue and decreased GSH, GSH-Px and catalase levels. On the other hand, oleuropein improved cardiac parameters and decreased inflammatory cytokine and oxidative stress levels in cardiac tissue.en_US
dc.identifier.doi10.1007/s00210-023-02828-4
dc.identifier.endpage3410en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue5en_US
dc.identifier.pmid37955692en_US
dc.identifier.scopus2-s2.0-85176361637en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3403en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-023-02828-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8866
dc.identifier.volume397en_US
dc.identifier.wosWOS:001104640000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectOleuropeinen_US
dc.subjectCardioprotective effecten_US
dc.subjectRaten_US
dc.titleCardioprotective effect of oleuropein in a cisplatin-induced cardiotoxicity model in ratsen_US
dc.typeArticleen_US

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