Evaluation of the pro-inflammatory cytokine gene polymorphisms in patients with periodontal disease

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dc.authorscopusid16836087000
dc.authorscopusid57223129073
dc.authorscopusid57195980063
dc.authorscopusid37070299900
dc.contributor.authorFentoğlu, Özlem
dc.contributor.authorTülüceoğlu, Eda Evgen
dc.contributor.authorDoğan, Esra Sinem Kemer
dc.contributor.authorDoğan, Burak
dc.date.accessioned2024-09-19T15:48:31Z
dc.date.available2024-09-19T15:48:31Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Periodontal diseases are chronic inflammatory pathologies including in pro-inflammatory cyto-kine-mediated pathogenesis and epigenetic characteristics. We aimed to evaluate pro-inflammatory cytokine [interleukin (IL)-1?, tumour necrosis factor-alpha (TNF-?), and IL-6] gene polymorphisms in patients with periodontal disease. Methods: Patients with periodontitis (n = 25), gingivitis (n = 22), and periodontally healthy controls (n = 18) were enrolled in this study. The periodontal parameters (plaque index, gingival index, probing pocket depth, percent-age of bleding on probing, and clinical attachment level) were recorded, and fasting venous blood samples were obtained. The genotypes and allele frequencies of TNF?-308,-238, IL-1?-511, +3953, IL-6-174,-572 polymor-phisms were performed using polymerase chain reaction–restriction fragment length polymorphism technique. Results: Patients with periodontitis had the highest IL-1? +3953, IL-6-174 ve TNF-?-238 heterozygot geno-types, clinical periodontal parameters and demographic characteristics. IL-1? +3953 [the risk allele 2 (A allele) (GA genotype)] led to an increased risk of periodontitis, IL-6-174 [the risk allele 2 (G/T allele) (CG/CT genotypes)] was associated with gingivitis. Conclusion: Our findings provide important evidence that pro-inflammatory cytokine gene polymorphisms may be involved in the pathogenesis of gingivitis and periodontitis. Control of the cytokine response associated with periodontal diseases may constitute a step towards improving public health by reducing mortality and morbidity rates associated with many infectious-inflammatory diseases. © 2022, AVES. All rights reserved.en_US
dc.identifier.doi10.54614/CRDS.2022.6203
dc.identifier.endpage200en_US
dc.identifier.issn2822-2555
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85169463143en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage196en_US
dc.identifier.trdizinid1119927en_US
dc.identifier.urihttps://doi.org/10.54614/CRDS.2022.6203
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1119927
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15116
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherAVESen_US
dc.relation.ispartofCurrent Research in Dental Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgingivitisen_US
dc.subjectinterleukin-1 betaen_US
dc.subjectInterleukine-6en_US
dc.subjectperiodontitisen_US
dc.subjectpolymorphismen_US
dc.subjecttumor necrosis factor alphaen_US
dc.titleEvaluation of the pro-inflammatory cytokine gene polymorphisms in patients with periodontal diseaseen_US
dc.title.alternativePeriodontal hastalıklı bireylerde pro-inflamatuar sitokin gen polimorfizmlerinin değerlendirilmesien_US
dc.typeArticleen_US

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