Sarcopenia and Myosteatosis Assessed by Magnetic Resonance Enterography May Predict Negative Outcomes in Patients with Crohn's Disease

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dc.authoridDIRICAN, EMRE/0000-0003-3550-1326
dc.contributor.authorCankurtaran, Rasim Eren
dc.contributor.authorGunes, Yasin Celal
dc.contributor.authorDirican, Emre
dc.contributor.authorAlgin, Oktay
dc.contributor.authorCankurtaran, Damla
dc.contributor.authorYurekli, Oyku Tayfur
dc.date.accessioned2024-09-18T20:13:32Z
dc.date.available2024-09-18T20:13:32Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground/Aims: Limited research has examined the clinical consequences of sarcopenia and myosteatosis in Crohn's disease. This study aimed to determine the prevalence, risk factors, and effects of sarcopenia and myosteatosis on prognostic outcomes in Crohn's disease patients who underwent magnetic resonance enterography. Materials and Methods: This retrospective observational study included 116 Crohn's disease patients who underwent magnetic resonance enterography between January 2015 and August 2021. Skeletal muscle index was the ratio of the cross-sectional area of skeletal muscles at the L3 vertebral level to the square of the neck in cross-sectional imaging. Sarcopenia was defined as skeletal muscle index <38.5 cm(2)/m(2) in women and <52.4 cm(2)/m(2) in men. Myosteatosis was considered positive if the ratio of the mean signal intensity of the psoas muscle to the mean signal intensity of the cerebrospinal fluid was above 0.107. Results: Among the negative results in the post-procedure follow-up of the patients, a significant increase was observed in the sarcopenia group regarding abscess and the need for surgery (P <.05). Anti-tumor necrosis factor initiation was found to be significantly higher in the follow-up than in patients without myosteatosis (P =.029). In the multivariate model established with these variables, the presence of sarcopenia in the surgical follow-up was odds ratio = 5.34 (CI: 1.02-28.03, P =.047) and was found to be significantly associated with the increased risk. Conclusions: The presence of myosteatosis and sarcopenia detected in magnetic resonance enterography may be a harbinger of negative outcomes in Crohn's disease patients. Nutritional support should be provided to these patients with the potential to alter the course of the disease.en_US
dc.identifier.doi10.5152/tjg.2023.22644
dc.identifier.endpage849en_US
dc.identifier.issn2148-5607
dc.identifier.issue8en_US
dc.identifier.pmid37404120en_US
dc.identifier.scopus2-s2.0-85166442617en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage839en_US
dc.identifier.trdizinid1241553en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2023.22644
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1241553
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9251
dc.identifier.volume34en_US
dc.identifier.wosWOS:001109157300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrohn's diseaseen_US
dc.subjectsarcopeniaen_US
dc.subjectmyosteatosisen_US
dc.subjectmagnetic resonance enterographyen_US
dc.subjectnegative outcomesen_US
dc.titleSarcopenia and Myosteatosis Assessed by Magnetic Resonance Enterography May Predict Negative Outcomes in Patients with Crohn's Diseaseen_US
dc.typeArticleen_US

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