Neuroprotective effects of amantadine for experimental acute carbon monoxide poisoning

Basit Öğe Kaydı
dc.authoridALAGOZ, ALI/0000-0002-7538-2213
dc.authoridYalvac, Mehmet/0000-0002-4342-4597
dc.authoridKAYIR, Selcuk/0000-0002-3176-7859
dc.authoridZengin, Musa/0000-0003-2249-6521
dc.contributor.authorZengin, E. N.
dc.contributor.authorKayir, S.
dc.contributor.authorDogan, G.
dc.contributor.authorZengin, M.
dc.contributor.authorEkici, A. Akdagli
dc.contributor.authorYalvac, M.
dc.contributor.authorAyaz, E.
dc.date.accessioned2024-09-18T19:54:16Z
dc.date.available2024-09-18T19:54:16Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Amantadine is known to have a neuroprotective effect in many neurolog-ical diseases. This study aims at investigating the neuroprotective effect of amantadine in rats ex-posed to carbon monoxide (CO) poisoning.MATERIALS AND METHODS: Rats were maintained under standard experimental labora-tory conditions and randomized into 4 different groups of 7 each namely control, amantadine on-ly, CO exposure, and amantadine + CO exposure. For immunohistochemical analysis, tissues tak-en from the prefrontal and hippocampal regions were taken into formalin and kept for at least one day. Afterward, the tissue was followed and blocked for paraffin blocking. N-Methyl D-Aspar-tate (NMDA) levels in homogenates were studied by the Enzyme-Linked Immunosorbent Assay (ELISA) method. Superoxide dismutase (SOD) and catalase (CAT) activities in the supernatants were studied with commercial kits. Nitric oxide (NO) and Asymmetric Dimethyl Arginine (ADMA) levels were studied by the ELISA method. En-zyme activity values were calculated by dividing the protein values in the supernatants and nor-malizing them.RESULTS: CAT, SOD, NMDA, ADMA, and NO levels were statistically significantly different between the groups (p < 0.05). According to post-hoc pairwise comparison test results, the values of the control and amantadine groups for CAT, SOD, NMDA, ADMA, and NO parameters were significantly higher than that of CO group. Similarly, values in the control and amantadine groups were considerably higher than values for the amantadine + CO group. NMDA values were significantly lower in group amantadine + CO than in CO group (p: 0.049).CONCLUSIONS: Apoptosis and endothelial damage after CO poisoning is a complex pro-cess, and amantadine administration has a limit-ed contribution in preventing this process.en_US
dc.identifier.endpage6927en_US
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid36263571en_US
dc.identifier.scopus2-s2.0-85140222563en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6919en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7606
dc.identifier.volume26en_US
dc.identifier.wosWOS:000877188200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmantadineen_US
dc.subjectBcl-2en_US
dc.subjectCarbon monoxideen_US
dc.subjectIntoxicationen_US
dc.subjectN-Metil D-Aspartateen_US
dc.subjectNeuroprotectiveen_US
dc.subjectPoisoningen_US
dc.subjectRaten_US
dc.titleNeuroprotective effects of amantadine for experimental acute carbon monoxide poisoningen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7606.pdf
Boyut:
716.7 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu