In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump
Yükleniyor...
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Enrofloxacin treatment of chickens infected with fluoroquinolone (FQ)-sensitive Campylobacter promoted the emergence of FQ-resistant Campylobacter mutants which propagated in the intestinal tract and recolonized the chickens. The recovered isolates were highly resistant to quinolone antibiotics but remained susceptible to non-FQ antimicrobial agents. Specific single-point mutations in the gyrA gene and the function of the CmeABC efflux pump were linked to the acquired FQ resistance. These results reveal that Campylobacter is hypermutable in vivo under the selection pressure of FQ and highlight the need for the prudent use of FQ antibiotics.
Açıklama
Anahtar Kelimeler
Animals, Anti-Infective Agents, Campylobacter Infections, Campylobacter jejuni, Chickens, Ciprofloxacin, DNA Gyrase, Drug Resistance, Microbial, Fluoroquinolones, Microbial Sensitivity Tests, Mutation, Nalidixic Acid, Quinolones, ciprofloxacin, enrofloxacin, quinoline derived antiinfective agent, animal experiment, animal model, antibiotic resistance, antibiotic sensitivity, article, bacterial colonization, bacterium isolate, bacterium mutant, Campylobacter, chicken, gene mutation, Gram negative infection, intestine, minimum inhibitory concentration, nonhuman, priority journal
Kaynak
Antimicrobial Agents and Chemotherapy
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
47
Sayı
1
